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Substrate competition reduces pro-inflammatory eicosanoid production: (Omega-6 PUFA) (Omega-3 PUFA) Massaro et.al. Prostaglandins Leukot Essent Fatty Acids. 2008 Oct 22
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Maternal Nutrition and Metabolic Pr
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Colorado Program in Nutrition and H
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Outline of Talk: 1) The new science
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Oct. 6, 2010
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March 18, 2010 700,000 children and
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World-Wide Childhood Obesity Epidem
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Prevalence (%) Prevalence of Type 2
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The “Obese Environment” • Adi
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When the two combine: Maternal Obes
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Co-Morbidities of Childhood Obesity
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Global projections for the diabetes
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The Developing World is catching up
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Fetal Origin of Adult Disease Fetal
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Infant Adiposity vs. BW Catalano, A
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First take home message: Its not al
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Figure 1. Complex Pathogenesis of T
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Obese Pregnancy and Fetal Nutrients
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NEWS & VIEWS Childhood obesity—me
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Adult NAFLD Insulin Resistance Obes
Page 40 and 41: Maternal diet-induced obesity alter
Page 42 and 43: Metabolic Programming in the Fetus:
Page 44 and 45: Benefits and Obstacles to working i
Page 46 and 47: A Primate Model Japanese Macaques @
Page 48 and 49: High Fat Diet Animals High Fat Diet
Page 50 and 51: Fetal Hepatic Pathology Under Condi
Page 52 and 53: -Elevated Stress Response in Fetal
Page 54 and 55: Model showing loss of Sirtuin 3 fun
Page 56 and 57: Chow Maternal Fetal Breast Milk * *
Page 58 and 59: Placenta Histology Control Pregnanc
Page 60 and 61: Fetal circulating cytokines Include
Page 62 and 63: Summary: Maternal HFD: • Signific
Page 64 and 65: Consumption During the Food Prefere
Page 66 and 67: Offspring from HFD fed mothers exhi
Page 68 and 69: Maternal HFD increases liver trigly
Page 70 and 71: (N=2-3 per group) Increased inflamm
Page 72 and 73: Putative Natural History of Fatty L
Page 74 and 75: 1 Lean Obese GDM Hx Screen: Consent
Page 76 and 77: Composition •Calories oLactose oP
Page 78 and 79: Neonatal %Body Fat Correlation Betw
Page 82 and 83: Roland-Valadez E et al. Ann Hepatol
Page 84 and 85: Variable ß - coefficient P-value M
Page 86 and 87: Fetal Hepatic Fat Accumulation Oxid
Page 88 and 89: Western Diet: High Saturated Fat Hi
Page 92 and 93: Omega-3 Fatty Acids In Non-Pregnant
Page 94 and 95: Hypothesis: Increasing maternal ome
Page 96 and 97: Early evidence of Fat-1 benefits: -
Page 98 and 99: HFD Mothers are significantly heavi
Page 100 and 101: 20 15 10 5 0 However, lipid deposit
Page 102 and 103: Increase in placental lipids also m
Page 104 and 105: Fetal serum
Page 106 and 107: Preliminary Microarray: How does th
Page 108 and 109: So what might this mean for adolesc
Page 110 and 111: Unlike traditional Barker Hypothesi
Page 112 and 113: Previous reports in adolescents fro
Page 114 and 115: Next Steps: - Analysis of maternal
Page 117 and 118: Last Take Home Message:
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Presentation - University of Colorado Denver

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