Presentation - University of Colorado Denver

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Hypothesis: Increasing maternal omega-3 (relative to omega-6) fatty acids will mitigate the effects <strong>of</strong> maternal obesity on adolescent metabolic health by reducing both placental and fetal exposure to excess maternal lipids and inflammation.
Transgenic Animal Model: The Fat-1 Mouse - Endogenously converts omega-6s to omega-3s - Expressed under actin promoter - Results in a tissue n-6:n-3 ratio ~1:1, without dietary change � fat-1 (C. elegans): Encodes n-3 desaturase J.X. Kang. Prostaglandins, Leukotrienes and Essential Fatty Acids: 77 (2007) 263–267. Kang et.al. Nature. 2004 Feb 19;427(6976):698.
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Maternal Nutrition and Metabolic Pr
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Colorado Program in Nutrition and H
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Outline of Talk: 1) The new science
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Oct. 6, 2010
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March 18, 2010 700,000 children and
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World-Wide Childhood Obesity Epidem
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Prevalence (%) Prevalence of Type 2
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The “Obese Environment” • Adi
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When the two combine: Maternal Obes
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Co-Morbidities of Childhood Obesity
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Global projections for the diabetes
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The Developing World is catching up
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Fetal Origin of Adult Disease Fetal
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Infant Adiposity vs. BW Catalano, A
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First take home message: Its not al
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Figure 1. Complex Pathogenesis of T
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Obese Pregnancy and Fetal Nutrients
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NEWS & VIEWS Childhood obesity—me
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Adult NAFLD Insulin Resistance Obes
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Maternal diet-induced obesity alter
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Metabolic Programming in the Fetus:
Page 44 and 45: Benefits and Obstacles to working i
Page 46 and 47: A Primate Model Japanese Macaques @
Page 48 and 49: High Fat Diet Animals High Fat Diet
Page 50 and 51: Fetal Hepatic Pathology Under Condi
Page 52 and 53: -Elevated Stress Response in Fetal
Page 54 and 55: Model showing loss of Sirtuin 3 fun
Page 56 and 57: Chow Maternal Fetal Breast Milk * *
Page 58 and 59: Placenta Histology Control Pregnanc
Page 60 and 61: Fetal circulating cytokines Include
Page 62 and 63: Summary: Maternal HFD: • Signific
Page 64 and 65: Consumption During the Food Prefere
Page 66 and 67: Offspring from HFD fed mothers exhi
Page 68 and 69: Maternal HFD increases liver trigly
Page 70 and 71: (N=2-3 per group) Increased inflamm
Page 72 and 73: Putative Natural History of Fatty L
Page 74 and 75: 1 Lean Obese GDM Hx Screen: Consent
Page 76 and 77: Composition •Calories oLactose oP
Page 78 and 79: Neonatal %Body Fat Correlation Betw
Page 82 and 83: Roland-Valadez E et al. Ann Hepatol
Page 84 and 85: Variable ß - coefficient P-value M
Page 86 and 87: Fetal Hepatic Fat Accumulation Oxid
Page 88 and 89: Western Diet: High Saturated Fat Hi
Page 90: Substrate competition reduces pro-i
Page 93: Omega-3 Fatty Acids and Pregnancy:
Page 97 and 98: Experiment Outline: 8 week-old Virg
Page 99 and 100: Fetuses from WT-HFD mothers have si
Page 101 and 102: What could be causing placental ove
Page 103 and 104: Lipoprotein Lipase (LPL) activity i
Page 105 and 106: 20 18 16 14 12 10 8 6 4 2 0 Fetal l
Page 107 and 108: Transcription expression patterns s
Page 109 and 110: Pups from WT-HFD moms are heavier,
Page 111 and 112: Could the “liver injury” pathwa
Page 113 and 114: Summary: Maternal obesity/HFD incre
Page 115: Acknowledgments: Mentor: Jed Friedm
Page 118: Thank You !
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Presentation - University of Colorado Denver

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