Presentation - University of Colorado Denver

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Next Steps: - Analysis of maternal frozen tissues: Inflammation, metabolic pathways - Analysis of maternal lipid trafficking (oxidation, storage) - Localize placental LPL and Macs by IHC - Staining of Fetal liver for apoptosis, fibrosis, oxidative stress - Fetal liver FA oxidation analysis - Continuation of juvenile offspring analyses
Acknowledgments: Mentor: Jed Friedman CTSI Clinical Mentor: Lynn Barbour Committee Members: Jim McManaman (Chair) Lynn Barbour Dwight Klemm Paul MacLean Pepper Schedin Virginia Winn Friedman Lab Rachel Janssen Becky DelaHoussaye Karalee Baquero Kristen Boyle Teri Hernandez Stephanie Thorn Mahua Choudhury Mizanoor Rahman David Brumbaugh Michael Stewart Emily Busta McCurdy Lab Carrie McCurdy Julie Houck Carlos Ainza Bergman Lab Bryan Bergman David Howard Funding: American Heart Association Colorado CTSI
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Maternal Nutrition and Metabolic Pr
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Colorado Program in Nutrition and H
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Outline of Talk: 1) The new science
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Oct. 6, 2010
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March 18, 2010 700,000 children and
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World-Wide Childhood Obesity Epidem
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Prevalence (%) Prevalence of Type 2
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The “Obese Environment” • Adi
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When the two combine: Maternal Obes
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Co-Morbidities of Childhood Obesity
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Global projections for the diabetes
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The Developing World is catching up
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Fetal Origin of Adult Disease Fetal
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Infant Adiposity vs. BW Catalano, A
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First take home message: Its not al
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Figure 1. Complex Pathogenesis of T
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Obese Pregnancy and Fetal Nutrients
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NEWS & VIEWS Childhood obesity—me
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Adult NAFLD Insulin Resistance Obes
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Maternal diet-induced obesity alter
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Metabolic Programming in the Fetus:
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Benefits and Obstacles to working i
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A Primate Model Japanese Macaques @
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High Fat Diet Animals High Fat Diet
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Fetal Hepatic Pathology Under Condi
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-Elevated Stress Response in Fetal
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Model showing loss of Sirtuin 3 fun
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Chow Maternal Fetal Breast Milk * *
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Placenta Histology Control Pregnanc
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Fetal circulating cytokines Include
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Summary: Maternal HFD: • Signific
Page 64 and 65: Consumption During the Food Prefere
Page 66 and 67: Offspring from HFD fed mothers exhi
Page 68 and 69: Maternal HFD increases liver trigly
Page 70 and 71: (N=2-3 per group) Increased inflamm
Page 72 and 73: Putative Natural History of Fatty L
Page 74 and 75: 1 Lean Obese GDM Hx Screen: Consent
Page 76 and 77: Composition •Calories oLactose oP
Page 78 and 79: Neonatal %Body Fat Correlation Betw
Page 82 and 83: Roland-Valadez E et al. Ann Hepatol
Page 84 and 85: Variable ß - coefficient P-value M
Page 86 and 87: Fetal Hepatic Fat Accumulation Oxid
Page 88 and 89: Western Diet: High Saturated Fat Hi
Page 90: Substrate competition reduces pro-i
Page 93 and 94: Omega-3 Fatty Acids and Pregnancy:
Page 95 and 96: Transgenic Animal Model: The Fat-1
Page 97 and 98: Experiment Outline: 8 week-old Virg
Page 99 and 100: Fetuses from WT-HFD mothers have si
Page 101 and 102: What could be causing placental ove
Page 103 and 104: Lipoprotein Lipase (LPL) activity i
Page 105 and 106: 20 18 16 14 12 10 8 6 4 2 0 Fetal l
Page 107 and 108: Transcription expression patterns s
Page 109 and 110: Pups from WT-HFD moms are heavier,
Page 111 and 112: Could the “liver injury” pathwa
Page 113: Summary: Maternal obesity/HFD incre
Page 118: Thank You !
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Presentation - University of Colorado Denver

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