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Preliminary Microarray: How does this impact the fetal liver? Is there a potential “program”? 6 maternally-unique fetal livers (all male), pooled into sets <strong>of</strong> 3 WT-Ctrl – Pool #1, Pool #2 WT-HFD – Pool #1, Pool #2 Fat1-HFD – Pool #1, Pool #2 Key transcription programs up/down with HFD: Proliferation FA Oxidation/Metabolism Inflammation (APR) Oxidative Stress Fibrosis Apoptosis
Transcription expression patterns similar to chronic liver injury: Tilg H and Day CP (2007) Management strategies in alcoholic liver disease Nat Clin Pract Gastroenterol Hepatol 4: 24–34 doi:10.1038/ncpgasthep0683
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Maternal Nutrition and Metabolic Pr
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Colorado Program in Nutrition and H
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Outline of Talk: 1) The new science
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Oct. 6, 2010
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March 18, 2010 700,000 children and
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World-Wide Childhood Obesity Epidem
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Prevalence (%) Prevalence of Type 2
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The “Obese Environment” • Adi
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When the two combine: Maternal Obes
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Co-Morbidities of Childhood Obesity
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Global projections for the diabetes
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The Developing World is catching up
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Fetal Origin of Adult Disease Fetal
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Infant Adiposity vs. BW Catalano, A
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First take home message: Its not al
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Figure 1. Complex Pathogenesis of T
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Obese Pregnancy and Fetal Nutrients
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NEWS & VIEWS Childhood obesity—me
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Adult NAFLD Insulin Resistance Obes
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Maternal diet-induced obesity alter
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Metabolic Programming in the Fetus:
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Benefits and Obstacles to working i
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A Primate Model Japanese Macaques @
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High Fat Diet Animals High Fat Diet
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Fetal Hepatic Pathology Under Condi
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-Elevated Stress Response in Fetal
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Model showing loss of Sirtuin 3 fun
Page 56 and 57: Chow Maternal Fetal Breast Milk * *
Page 58 and 59: Placenta Histology Control Pregnanc
Page 60 and 61: Fetal circulating cytokines Include
Page 62 and 63: Summary: Maternal HFD: • Signific
Page 64 and 65: Consumption During the Food Prefere
Page 66 and 67: Offspring from HFD fed mothers exhi
Page 68 and 69: Maternal HFD increases liver trigly
Page 70 and 71: (N=2-3 per group) Increased inflamm
Page 72 and 73: Putative Natural History of Fatty L
Page 74 and 75: 1 Lean Obese GDM Hx Screen: Consent
Page 76 and 77: Composition •Calories oLactose oP
Page 78 and 79: Neonatal %Body Fat Correlation Betw
Page 82 and 83: Roland-Valadez E et al. Ann Hepatol
Page 84 and 85: Variable ß - coefficient P-value M
Page 86 and 87: Fetal Hepatic Fat Accumulation Oxid
Page 88 and 89: Western Diet: High Saturated Fat Hi
Page 90: Substrate competition reduces pro-i
Page 93 and 94: Omega-3 Fatty Acids and Pregnancy:
Page 95 and 96: Transgenic Animal Model: The Fat-1
Page 97 and 98: Experiment Outline: 8 week-old Virg
Page 99 and 100: Fetuses from WT-HFD mothers have si
Page 101 and 102: What could be causing placental ove
Page 103 and 104: Lipoprotein Lipase (LPL) activity i
Page 105: 20 18 16 14 12 10 8 6 4 2 0 Fetal l
Page 109 and 110: Pups from WT-HFD moms are heavier,
Page 111 and 112: Could the “liver injury” pathwa
Page 113 and 114: Summary: Maternal obesity/HFD incre
Page 115: Acknowledgments: Mentor: Jed Friedm
Page 118: Thank You !
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Presentation - University of Colorado Denver

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