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Maternal Nutrition and Metabolic Pr
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Colorado Program in Nutrition and H
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Outline of Talk: 1) The new science
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Oct. 6, 2010
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March 18, 2010 700,000 children and
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World-Wide Childhood Obesity Epidem
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Prevalence (%) Prevalence of Type 2
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The “Obese Environment” • Adi
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When the two combine: Maternal Obes
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Co-Morbidities of Childhood Obesity
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Global projections for the diabetes
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The Developing World is catching up
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Fetal Origin of Adult Disease Fetal
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Infant Adiposity vs. BW Catalano, A
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First take home message: Its not al
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Figure 1. Complex Pathogenesis of T
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Obese Pregnancy and Fetal Nutrients
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NEWS & VIEWS Childhood obesity—me
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Adult NAFLD Insulin Resistance Obes
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Maternal diet-induced obesity alter
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Metabolic Programming in the Fetus:
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Benefits and Obstacles to working i
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A Primate Model Japanese Macaques @
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High Fat Diet Animals High Fat Diet
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Fetal Hepatic Pathology Under Condi
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-Elevated Stress Response in Fetal
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Model showing loss of Sirtuin 3 fun
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Chow Maternal Fetal Breast Milk * *
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Placenta Histology Control Pregnanc
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Fetal circulating cytokines Include
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Summary: Maternal HFD: • Signific
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- Page 66 and 67: Offspring from HFD fed mothers exhi
- Page 68 and 69: Maternal HFD increases liver trigly
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- Page 72 and 73: Putative Natural History of Fatty L
- Page 74 and 75: 1 Lean Obese GDM Hx Screen: Consent
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- Page 82 and 83: Roland-Valadez E et al. Ann Hepatol
- Page 84 and 85: Variable ß - coefficient P-value M
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- Page 88 and 89: Western Diet: High Saturated Fat Hi
- Page 90: Substrate competition reduces pro-i
- Page 93 and 94: Omega-3 Fatty Acids and Pregnancy:
- Page 95 and 96: Transgenic Animal Model: The Fat-1
- Page 97 and 98: Experiment Outline: 8 week-old Virg
- Page 99 and 100: Fetuses from WT-HFD mothers have si
- Page 101 and 102: What could be causing placental ove
- Page 103 and 104: Lipoprotein Lipase (LPL) activity i
- Page 105 and 106: 20 18 16 14 12 10 8 6 4 2 0 Fetal l
- Page 107 and 108: Transcription expression patterns s
- Page 109 and 110: Pups from WT-HFD moms are heavier,
- Page 111 and 112: Could the “liver injury” pathwa
- Page 113: Summary: Maternal obesity/HFD incre
- Page 118: Thank You !