Presentation - University of Colorado Denver
Presentation - University of Colorado Denver
Presentation - University of Colorado Denver
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Summary: Maternal HFD:<br />
• Significant impact on placental function & development<br />
– Cytokine production – n6/n3 increased in developing fetus<br />
– Decreased placental function – exacerbated in HFD-S mothers<br />
• Increased early adiposity and glucose intolerance<br />
– Fatty liver (Inflammation, steatosis), insulin resistance maintained in<br />
Juvenile livers.<br />
– Epigenetics –HSP70, Bmal1 (clock gene family) (FASEB J, 2010).<br />
– Pancreatic islet hyperplasia<br />
– Hyperphagia <strong>of</strong> palatable diets<br />
– Abnormalities in the melanocortin system (Endocrinology 2010).<br />
• Social Behavior<br />
– Decreased Serotonin (J Neurosci, 2010)<br />
– Female Offspring – increased anxiety<br />
– Male <strong>of</strong>fspring – increased aggressive behavior<br />
– Both sexes display decreases in social behavior<br />
• Is NOT solely dependent on maternal obesity
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