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(12) PATENT APPLICATION PUBLICATION (21) Application No.2873/DELNP/2005 A
(19) INDIA
(22) Date of filing of Application :28/06/2005 (43) Publication Date : 16/03/2007
(54) Title of the invention : "KINASES AND GPCRS INVOLVED IN APOPTOSIS"
(51) International classification :G01N 33/50 (71)Name of Applicant :
(31) Priority Document No :0301566.6
1)EIRX THERAPEUTICS LIMITED
(32) Priority Date :23/01/2003
Address of Applicant :2800 CORK AIRPORT BUSINESS PARK,
(33) Name of priority country :U.K.
KINSALE ROAD, CORK, CO. CORK, IRELAND. Ireland
(86) International Application No
:PCT/GB2004/000271 (72)Name of Inventor :
Filing Date
:23/01/2004
1)LIAM SEERY
(87) International Publication No :WO 2004/065959 2)IAN HAYES
(61) Patent of Addition to Application Number :NA
Filing Date
:NA
(62) Divisional to to Application Number
:NA
Filing Date
:NA
No of Pages : 162 No of Claims : 39
(57) Abstract :
The present invention relates to a method of identifying an agent that modulates the function of an apoptosis-associated polypeptide having a sequence as set
out in Table IB, the method comprising: (a) providing a sample containing an apoptosis-associated polypeptide having a sequence as set out in Table IB, and
a candidate agent and incubating under conditions to permit binding of the candidate agent to the polypeptide; (b) measuring the binding of the apoptosisassociated
polypeptide having a sequence as set out in Table IB to the candidate agent in the sample; and (c) comparing the binding of the apoptosisassociated
polypeptide having a sequence as set out in Table IB to the candidate agent in the sample with the binding of the polypeptide having a sequence as
set out in Table IB to a control agent, wherein the control agent is known to not bind to the polypeptide having a sequence as set out in Table IB; wherein an
increase in the binding of the apoptosis-associated polypeptide having a sequence as set out in Table IB to the candidate agent in the sample relative to the
binding of the apoptosis-associated polypeptide having a sequence as set out in Table IB to the control agent indicates that the candidate agent modulates the
function of the apoptosis-associated polypeptide having a sequence as set out in Table IB.
The Patent Office Journal 16/03/2007 5920