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official journal of the patent office - Controller General of Patents ...

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(12) PATENT APPLICATION PUBLICATION (21) Application No.01894/DELNP/2003 A<br />

(19) INDIA<br />

(22) Date <strong>of</strong> filing <strong>of</strong> Application :12/11/2003 (43) Publication Date : 16/03/2007<br />

(54) Title <strong>of</strong> <strong>the</strong> invention : "IMMUNOGENIC PEPTIDE COMPOSITION FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE"<br />

(51) International classification :A61K<br />

(71)Name <strong>of</strong> Applicant :<br />

(31) Priority Document No :09/865,294 1)UNITED BIOMEDICAL, INC.<br />

(32) Priority Date :25/05/2001 Address <strong>of</strong> Applicant :25 DAVIDS DRIVE, HAUPPAUGE, NY 11788,<br />

(33) Name <strong>of</strong> priority country :U.S.A. USA. U.S.A.<br />

(86) International Application No<br />

:PCT/US02/10293 (72)Name <strong>of</strong> Inventor :<br />

Filing Date<br />

:02/04/2002 1)WANG, CHANG, YI<br />

(87) International Publication No :WO 02/096350<br />

(61) Patent <strong>of</strong> Addition to Application Number<br />

:NA<br />

Filing Date<br />

:NA<br />

(62) Divisional to to Application Number<br />

:NA<br />

Filing Date<br />

:NA<br />

No <strong>of</strong> Pages : 57 No <strong>of</strong> Claims : 80<br />

(57) Abstract :<br />

The presenl invention relates to a composition comprising a peptide immunogen useful for <strong>the</strong> prevention and treatment <strong>of</strong> Al/.heimcr's Disease. More<br />

particularly, Ihe peplide immunogen comprises a main runclional/regulalory sile. an N-lerminal fragment <strong>of</strong> Amyloid t>(AL'>) peplide linked to a helper T<br />

cell epitope (Th) having multiple class II M1IX binding motif's. The pep-tide immunogen clicil a sile-directed immune response against <strong>the</strong> main<br />

funclional/regulalory sile <strong>of</strong> ihe AB peplide and generate antibodies, which are highly cross-reaclive to <strong>the</strong> soluble ALV-12 peplide and Ihe amyloid plaques<br />

formed in <strong>the</strong> brain <strong>of</strong> Al/.heimcr s Disease patienls. The antibodies elicited being cross reactive to <strong>the</strong> soluble Ati|_i2 peplide. promole fibril disaggregalion<br />

and inhibit fibrillar aggregalion leading lo immunoneuirali/.alion <strong>of</strong> <strong>the</strong> "soluble AB-derived toxins": and being cross-reaclive lo ihe amyloid plaques,<br />

accelerate <strong>the</strong> clearance <strong>of</strong> <strong>the</strong>se plaques from <strong>the</strong> brain. Thus, <strong>the</strong> composition <strong>of</strong> ihe invention comprising <strong>the</strong> peplide immunogen is useful for <strong>the</strong><br />

prevention and treatment <strong>of</strong> Al/.heimer s Disease.<br />

The Patent Office Journal 16/03/2007 5689

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