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official journal of the patent office - Controller General of Patents ...

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(12) PATENT APPLICATION PUBLICATION (21) Application No.1495/DELNP/2004 A<br />

(19) INDIA<br />

(22) Date <strong>of</strong> filing <strong>of</strong> Application :01/06/2004 (43) Publication Date : 16/03/2007<br />

(54) Title <strong>of</strong> <strong>the</strong> invention : LIPOSOME COMPOSITION FOR DELIVERY OF NUCLEIC ACID<br />

(51) International classification :A61K 9/127 (71)Name <strong>of</strong> Applicant :<br />

(31) Priority Document No :10/020,671 1)ALZA CORPORATION<br />

(32) Priority Date :12/12/2001 Address <strong>of</strong> Applicant :1900 CHARLESTON ROAD, P.O. BOX 7210,<br />

(33) Name <strong>of</strong> priority country :U.S.A. MOUNTAIN VIEW, CA 94039-7210, UNITED STATES OF AMERICA<br />

(86) International Application No<br />

:PCT/US02/41461 U.S.A.<br />

Filing Date<br />

:05/12/2002 (72)Name <strong>of</strong> Inventor :<br />

(87) International Publication No<br />

:W2 03/053409<br />

A1<br />

1)HUANG, SHI-KUN<br />

2)ZALIPSKY, SAMUEL<br />

(61) Patent <strong>of</strong> Addition to Application Number<br />

:NA<br />

3)ZHANG, WEI-MING<br />

Filing Date<br />

:NA<br />

(62) Divisional to to Application Number<br />

:NA<br />

Filing Date<br />

:NA<br />

No <strong>of</strong> Pages : 60 No <strong>of</strong> Claims : 27<br />

(57) Abstract :<br />

A liposome composition for delivery <strong>of</strong> a nucleic acid in vivo or ex vivo is described. The liposomes in <strong>the</strong> composition are comprised <strong>of</strong> (i) a lipid that is<br />

neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a<br />

dithiobenzyI linkage. The liposomes are associated with a nucleic acid for delivery to a cell.<br />

The Patent Office Journal 16/03/2007 5807

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