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(12) PATENT APPLICATION PUBLICATION (21) Application No.325/CHE/2005 A
(19) INDIA
(22) Date of filing of Application :29/03/2005 (43) Publication Date : 16/03/2007
(54) Title of the invention : MULTIPARTICULATE PHARMACEUTICAL FORM COMPRISING PELLETS
WITH A MATRIX WHICH IN FLUENCES THE DELIVERY OF A MODULATORY SUBSTANCE
(51) International classification :A61K 9/22
(31) Priority Document No :NA
(32) Priority Date :NA
(33) Name of priority country :NA
(86) International Application No :NA
Filing Date
:NA
(87) International Publication No : NA
(61) Patent of Addition to Application :NA
Number
Filing Date
:NA
(62) Divisional to to Application :NA
Number
Filing Date
:NA
(71)Name of Applicant :
1)ROHM GMBH & CO.KG.
Address of Applicant :KIRSCHENALLEE 5, D-
64293, DARMSTADT, Germany
(72)Name of Inventor :
1)RAVISHANKAR , HEMA,
2)PETEREIT ,HANS -ULRICH,
3)LIZIO, ROSARIO,
No of Pages : 42 No of Claims : 11
(57) Abstract :
The invention relates to a multiparticulate pharmaceutical form, comprising pellets with a
multilayer structure for controlled active ingredient release, comprising optionally a neutral core
(nonpareilles), b) an inner controlling layer comprising a substance having a modulating effect,
which is embedded in a matrix which influences the delivery of the modulatory substance and
which comprises pharmaceutically usable polymers, waxes, resins and/or proteins, and where
appropriate an active ingredient, c) an active ingredient layer comprising an active pharmaceutical
ingredient and, where appropriate, a substance having a modulating effect, an outer controlling
layer comprising at least 60% by weight of one or a mixture of a plurality of (meth)acrylate
copolymers where the outer controlling layer has a thickness from 20 to less than 55 IJ.m and
contains 0,1 to 10% by weight of glycerol monostearate, where the multiparticulate pharmaceutical
form contains 20 to 60% by weight of the pellets, which are compressed in mixture with 80 to 40%
by weight of an outer phase which consists from 50 to 100% by weight of a cellulose or a derivate
of cellulose and optionally 0 to 50% by weight of further pharmaceutical excipients.
The Patent Office Journal 16/03/2007 5334