PCT/1998/22 - World Intellectual Property Organization

22/1998
4 Jun/juin 1998 PCT Gazette - Section I - Gazette du PCT 9805
(74) ARUGA, Mitsuyuki et al. / etc.; Kyodo Building,
3–6, Nihonbashiningyocho 1–chome, Chuo–ku,
Tokyo 103 (JP).
(81) CA JP KR US; EP (AT BE CH DE DK ES FI FR
GB GR IE IT LU MC NL PT SE).
(11) WO 98/23593 (13) A1
(21) PCT/IB97/01368
(22) 3 Nov/nov 1997 (03.11.1997)
(25) en (26) en
(31) 60/032,307 (32) 27 Nov/nov 1996 (33) US
(27.11.1996)
(43) 4 Jun/juin 1998 (04.06.1998)
(51) 6 C07D 217/04, 405/06, 401/06, 409/06, A61K
31/47
(54) APO B–SECRETION/MTP INHIBITORY
AMIDES
AMIDES INHIBANT LA SECRETION D’Apo B
ET/OU LA PROTEINE MTP
(71) PFIZER INC. [US/US]; 235 East 42nd Street, New
York, NY 10017 (US).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) CHANG, George [US/US]; 1 Winthrop Hill
Road, Ivoryton, CT 06442 (US). QUALLICH,
George, Joseph [US/US]; 349 Norwich Westerly
Road, North Stonington, CT 06359 (US).
(74) SPIEGEL, Allen, J. et al. / etc.; Pfizer Inc., 235
East 42nd Street, New York, NY 10017 (US).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE HU IL IS JP
KE KG KP KR KZ LC LK LR LS LT LU LV MD
MG MK MN MW MX NO NZ PL PT RO RU SD
SE SG SI SK TJ TM TR TT UA UG US UZ VN
YU; AP (GH KE LS MW SD SZ UG ZW); EA
(AM AZ BY KG KZ MD RU TJ TM); EP (AT BE
CH DE DK ES FI FR GB GR IE IT LU MC NL
PT SE); OA (BF BJ CF CG CI CM GA GN ML
MR NE SN TD TG).
(11) WO 98/23594 (13) A1
(21) PCT/JP97/04374
(22) 1 Dec/déc 1997 (01.12.1997)
(25) ja (26) ja
(31) 8/320241 (32) 29 Nov/nov 1996 (33) JP
(29.11.1996)
(43) 4 Jun/juin 1998 (04.06.1998)
(51) 6 C07D 225/06, A61K 31/395, C12P 17/10 //
C12N 1/20, (C12P 17/10, C12R 1:465) (C12N
1/20, C12R 1:465)
(54) CYTOTRIENINS, PROCESS FOR PREPARING
THE SAME, AND ANTITUMOR AGENT
CYTOTRIENINES, LEUR PROCEDE DE PRE-
PARATION ET AGENT ANTITUMORAL
(71) THE INSTITUTE OF PHYSICAL AND CHE-
MICAL RESEARCH [JP/JP]; 2–1, Hirosawa,
Wako–shi, Saitama–ken 351–01 (JP).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) OSADA, Hiroyuki [JP/JP]; The Institute of
Physical and Chemical Research, 2–1, Hirosawa,
Wako–shi, Saitama–ken 351–01 (JP). KAKEYA,
Hideaki [JP/JP]; The Institute of Physical and
Chemical Research, 2–1, Hirosawa, Wako–shi,
Saitama–ken 351–01 (JP). ZHANG, Hui–ping
[CN/JP]; The Institute of Physical and Chemical
Research, International House, F 301, 2–4,
Hirosawa, Wako–shi, Saitama–ken 351–01 (JP).
KOBINATA, Kimie [JP/JP]; The Institute of
Physical and Chemical Research, 2–1, Hirosawa,
Wako–shi, Saitama–ken 351–01 (JP).
(74) NAKAMURA, Minoru et al. / etc.; Shin–Tokyo
Building, Room 646, 3–1, Marunouchi 3–chome,
Chiyoda–ku, Tokyo 100 (JP).
(81) US; EP (AT BE CH DE DK ES FI FR GB GR IE
IT LU MC NL PT SE).
(11) WO 98/23595 (13) A1
(21) PCT/US97/21646
(22) 25 Nov/nov 1997 (25.11.1997)
(25) en (26) en
(31) 60/034,318 (32) 25 Nov/nov 1996
(25.11.1996)
(43) 4 Jun/juin 1998 (04.06.1998)
(33) US
(51) 6 C07D 233/50, 401/12, 403/12, 405/12, 417/12,
215/38
(54) PROCESS FOR MAKING 2–AMINO–2–
IMIDAZOLINE, GUANIDINE, AND 2–AMINO–
3,4,5,6–TETRAHYDROPYRIMIDINE DERIVA-
TIVES
PROCEDE DE FABRICATION DE DERIVES 2–
AMINO–2–IMIDAZOLINE, GUANIDINE, ET 2–
AMINO–3,4,5,6–TETRAHYDROPYRIMIDINE
(71) THE PROCTER & GAMBLE COMPANY
[US/US]; One Procter & Gamble Plaza, Cincinnati,
OH 45202 (US).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) GODLEWSKI, Michael [US/US]; HCR 67,
Box 272, South Plymouth, NY 13844 (US).
KLOPFENSTEIN, Sean, Rees [US/US]; 11721
Thistlehill Drive, Loveland, OH 45140 (US).
MUNDLA, Screenivasa, Reddy [US/US]; Apartment
#W12, 30 Midland Drive, Norwich, NY
13815 (US). SEIBEL, William, Lee [US/US];
5704 Somerset Drive, Hamilton, OH 45011 (US).
(74) REED, T., David et al. / etc.; The Procter &
Gamble Company, 5299 Spring Grove Avenue,
Cincinnati, OH 45217 (US).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH HU ID
IL IS JP KE KG KP KR KZ LC LK LR LS LT
LU LV MD MG MK MN MW MX NO NZ PL PT
RO RU SD SE SG SI SK SL TJ TM TR TT UA
UG US UZ VN YU ZW; AP (GH KE LS MW SD
SZ UG ZW); EA (AM AZ BY KG KZ MD RU TJ
TM); EP (AT BE CH DE DK ES FI FR GB GR
IE IT LU MC NL PT SE); OA (BF BJ CF CG CI
CM GA GN ML MR NE SN TD TG).
Published / Publiée : (c)
(11) WO 98/23596 (13) A1
(21) PCT/US97/20802
(22) 21 Nov/nov 1997 (21.11.1997)
(25) en (26) en
(31) 60/032,023 (32) 25 Nov/nov 1996
(25.11.1996)
(43) 4 Jun/juin 1998 (04.06.1998)
(51) 6 C07D 235/06, A61K 31/395, C07D 215/38,
277/62
(33) US
(54) GUANIDINYL HETEROCYCLE COMPOUNDS
USEFUL AS ALPHA–2 ADRENOCEPTOR AGO-
NISTS
COMPOSES GUANIDINYL HETEROCYCLES
CONVENANT COMME AGONISTES DE
L’ADRENORECEPTEUR ALPHA–2
(71) THE PROCTER & GAMBLE COMPANY
[US/US]; One Procter & Gamble Plaza, Cincinnati,
OH 45202 (US).
(for all designated States except / pour tous les États
désignés sauf US)
(72, 75) CUPPS, Thomas, Lee [US/US]; 405 Pamela
Drive, Oxford, OH 45056 (US). BOGDAN, Sophie,
Eva [US/US]; 714 East Foster–Maineville
Road, Maineville, OH 45039 (US). HENRY,
Raymond, Todd [US/US]; 877 Hechterman Road,
Pleasant Plain, OH 45162 (US). SHELDON,
Russell, James [US/US]; 5023 Winton Road,
Fairfield, OH 45014 (US). SEIBEL, William, Lee
[US/US]; 5704 Somerset Drive, Hamilton, OH
45011 (US). ARES, Jeffrey, Joseph [US/US];
4176 Bennett Drive, Hamilton, OH 45011 (US).
(74) REED, T., David et al. / etc.; The Procter &
Gamble Company, 5299 Spring Grove Avenue,
Cincinnatti, OH 45217 (US).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH HU ID
IL IS JP KE KG KP KR KZ LC LK LR LS LT
LU LV MD MG MK MN MW MX NO NZ PL PT
RO RU SD SE SG SI SK SL TJ TM TR TT UA
UG US UZ VN YU ZW; AP (GH KE LS MW SD
SZ UG ZW); EA (AM AZ BY KG KZ MD RU TJ
TM); EP (AT BE CH DE DK ES FI FR GB GR
IE IT LU MC NL PT SE); OA (BF BJ CF CG CI
CM GA GN ML MR NE SN TD TG).
Published / Publiée : (c)
(11) WO 98/23597 (13) A1
(21) PCT/KR97/00155
(22) 20 Aug/Août 1997 (20.08.1997)
(25) en (26) en
(31) 1996/58702 (32) 28 Nov/nov 1996 (33) KR
(28.11.1996)
(43) 4 Jun/juin 1998 (04.06.1998)
(51) 6 C07D 239/48, 403/04, 403/06, 239/50, 401/04,
401/06, 405/04, 409/04
(54) 4,5–DIAMINOPYRIMIDINE DERIVATIVES
AND A METHOD FOR THE PREPARATION
THEREOF
DERIVES DE 4,5–DIAMINOPYRIMIDINE ET
LEUR PROCEDE DE PREPARATION
(71) CHEIL JEDANG CORPORATION [KR/KR];
Cheil Building, 500, 5–ga, Namdaemun–ro,
Chung–ku, Seoul 100–095 (KR).
(72) XIANG, Myung, Xik; Injungprince Apt.,
1004–1002, Youbangdong, 1007–1, Yongin–shi,
Kyungkee–do 449–800 (KR). SUH, Byoung,
Chool; Munjungshiyoung Apt., 7–802, Munjungdong,
Songpa–ku, Seoul 138–200 (KR).
RHEE, Chung, Keun; Woosunggreen Apt.,
106–1303, San2–106, Dapshipli 4–dong, Dongdaemun–ku,
Seoul 130–034 (KR). LEE, Kwang,
Hyuk; 185, Yatopdong, Boondang–ku, Sungnamshi,
Kyungkeedo 463–070 (KR). LEE,
Youn, Ha; Sambolife Apt., 702–301 Kimrangjang–dong,
Yongin–shi, Kyungkee–do 449–800
(KR). KIM, Young, Gi; Dunchundong 52–7, 202,
Kangdong–ku, Seoul 134–062 (KR).
(74) CHOI, Hak, Hyun et al. / etc.; Peeres Building,
6th floor, 222, 3–ka, Chungjung–ro, Seodaemun–ku,
Seoul 120–013 (KR).
(81) AL AM AT AU AZ BA BB BG BR BY CA CH
CN CU CZ DE DK EE ES FI GB GE GH HU IL
IS JP KE KG KP KR KZ LC LK LR LS LT LU
LV MD MG MK MN MW MX NO NZ PL PT RO
RU SD SE SG SI SK SL TJ TM TR TT UA UG
UZ VN YU ZW; AP (GH KE LS MW SD SZ UG
ZW); EA (AM AZ BY KG KZ MD RU TJ TM);
EP (AT BE CH DE DK ES FI FR GB GR IE IT
LU MC NL PT SE); OA (BF BJ CF CG CI CM
GA GN ML MR NE SN TD TG).
(11) WO 98/23598 (13) A1
(21) PCT/EP97/06367
(22) 14 Nov/nov 1997 (14.11.1997)
(25) de (26) de