Issue 10 Volume 41 May 16, 2003

ound to the surface. Micropatterns of adhesion molecules were generated using photolithographic techniques. Dissociated
neurons from chicken dorsal root ganglia adhere selectively to the adhesion molecules and form networks. It could be
demonstrated that a single neuron can be stimulated by an adjacent microelectrode. The neural outgrowth was much improved
on the specific adhesion proteins axonin-1 and NgCAM, compared to surfaces treated with aminosilane. Furthermore, the
distance of cell membrane to surface was at a minimum on these specific neural adhesion proteins. These results show that
the quality of neuron cultures on chips can be improved if specific neural adhesion proteins are used.
DTIC
Glass; Gold; Neurons; Microelectronics; Electrodes; Chips (Electronics)
20030033103 Massachusetts Inst. of Tech., Cambridge, MA
A PC-Based Instrumentation Board That Overcomes Many Drawbacks of Typical Commercial Data Acquisition
Systems for Electrophysiological Recording Applications
Martel, S.; Lafontaine, S.; Hunter, I.; Oct 2001; 5 pp.; In English
Report No.(s): AD-A410596; No Copyright; Avail: CASI; A01, Hardcopy
The accessibility of adequate instrumentation to conduct fundamental researches for the development of new diagnostic
tools and methods in electrophysiology is essential. As such, many researchers develop proprietary instrumentation systems
based on commercially available data acquisition boards. These boards are typically not designed for recording
electrophysiological signals and as such, they may introduce significant error artifacts such as signal distortions, which in turn
may lead to false interpretations. In this paper, we describe a data acquisition board that has the specifications required to
adequately record many electrophysiological signals under difficult conditions, as it is often the case in a fundamental research
environment. Furthermore, unlike other comparable in-house systems, it enables custom hardware functions to be
implemented to support specific requirements encountered in a research environment. The card can also be installed directly
in any modern personal computers offering an inexpensive, open, powerful, and very flexible system allowing researchers to
easily take advantage of both commercial hardware and software to tailor the final system configuration for their particular
needs.
DTIC
Data Acquisition; Circuits
20030033110 Massachusetts Inst. of Tech., Cambridge, MA
A Universal Front-End Stage for Electrophysiological Mappings
Martel, S.; Hunter, I.; Oct 2001; 5 pp.; In English; Original contains color illustrations
Report No.(s): AD-A410598; No Copyright; Avail: CASI; A01, Hardcopy
This paper describes a front-end stage that has been implemented and embedded into instruments dedicated to a wide
variety of electrophysiological mapping applications. Emphasis during the design phase has been put towards flexibility,
simplicity, and performance in various environments.
DTIC
Circuits; Central Processing Units; Electrophysiology; Mapping
20030033112 Massachusetts Inst. of Tech., Cambridge, MA
A Mechanically Flexible, Battery-Powered, Differential Electrode Unit for Electrophysiological Recordings
Martel, S.; Jones, L.; Hunter, I.; Oct 2001; 4 pp.; In English; Original contains color illustrations
Report No.(s): AD-A410601; No Copyright; Avail: CASI; A01, Hardcopy
This paper describes a new type of micro-powered electrode configuration. The circuit consists of an instrumentation
amplifier and a special AC coupling configuration that maintains a high CMRR with a gain of a 1000. All electronics, including
two lithium batteries, are mounted on a flexible circuit board (FPC). The single FPC has a special shape that allows differential
recording at various distances between the electrodes. The whole circuit is typically popped onto EMG electrodes so that it
can be re-used many times.
DTIC
Circuit Boards; Recording; Lithium Batteries; Electrodes; Electromyography; Electrophysiology
20030033119 Erlangen-Nuernberg Univ., Erlangen, Germany
Testing of Josephson Array Antennas and Trim Current Tuning
Abdumalikov, A. A.; Caputo, P.; Ustinov, A. V.; Sep. 2002; 31 pp.; In English; Original contains color illustrations
Contract(s)/Grant(s): F61775-00-C-0004
Report No.(s): AD-A410720; EOARD-SPC-00-4046; No Copyright; Avail: CASI; A03, Hardcopy
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