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miolo final 1 - Revista Panamericana de Infectología

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<strong>Revista</strong> <strong>Panamericana</strong> <strong>de</strong> <strong>Infectología</strong> • Volumen 6 • Nº 1 • Ene-Mar/2004<br />

<strong>de</strong> la aminosidina y el extracto <strong>de</strong> propóleos al 30%<br />

durante 20 días tienen buena eficacia contra la<br />

infección por G. lamblia en niños y pue<strong>de</strong>n constituir<br />

medicamentos alternativos en pacientes con<br />

intolerancia a otras drogas antigiardiásicas; sin<br />

embargo, esta última opción sería menos recomendada<br />

por la mayor duración <strong>de</strong>l esquema terapéutico.<br />

Sugerimos continuar el estudio <strong>de</strong> los <strong>de</strong>rivados <strong>de</strong><br />

propóleos o sus principios activos en la búsqueda <strong>de</strong><br />

otras opciones terapéuticas eficaces contra la<br />

giardiasis.<br />

Referencias<br />

1. Adam RD. The biology of Giardia spp. Microbiol Rev<br />

1991;55:706-732.<br />

2. Núñez FA. Giardia lamblia. En: Llop A, Valdés-Dapena<br />

M, Suazo JL, editores. Microbiología y Parasitología Médicas.<br />

Tomo III. Capítulo 78. Ciudad <strong>de</strong> La Habana: Editorial<br />

<strong>de</strong> Ciencias Médicas; 2001. p.31-38.<br />

3. Hill DR. Giardiasis. Issues in diagnosis and management.<br />

Infect Dis Clin North Am 1993;7:503-525.<br />

4. Ortega YR, Adam RD. Giardia: Overview and update. Clin<br />

Infect Dis 1997;25:545-50.<br />

5. Khaw M, Panosian CB. Human antiprotozoal therapy: past,<br />

present and future. Clin Microbiol Rev 1995;8:427-439.<br />

6. Upcroft JA, Campbell RW, Benakli K, Upcroft P, Vanelle<br />

P. The efficacy of new 5-nitroimidazoles against<br />

metronidazole – susceptible and – resistant anaerobic<br />

protozoa. Antimicrob Agents Chemother 1999;43:73 -76.<br />

7. Land KM, Johnson PJ. Molecular basis of metronidazole<br />

resistance in pathogenic bacteria and protozoa. Drug<br />

Resist Updat 1999;2:289-294.<br />

8. Gardner TB, Hill DR. Treatment of giardiasis. Clin<br />

Microbiol Rev 2001;4:114-128.<br />

9. Torres D, Hollands I, Palacios E. Efecto <strong>de</strong> un extracto<br />

alcohólico <strong>de</strong> propóleos sobre el crecimiento <strong>de</strong> Giardia<br />

lamblia in vitro. Rev Cubana Cienc Vet 1990;21:15-20.<br />

10.Garcia LS, Bruckner DA. Macroscopic and microscopic<br />

examination of fecal specimens. In: Diagnostic Medical<br />

Parasitology. Washington, DC: American Society for Microbiology;<br />

1993. p.501–540.<br />

11.Upcroft P, Upcroft JA. Drugs targets and mechanisms of<br />

resistance in the anaerobic protozoa. Clin Microbiol Rev<br />

2001;14:150-164.<br />

12.Lindquist HDA. Induction of albendazol resistance in<br />

Giardia lamblia. Microb Drug Resist 1996;2:433-434.<br />

13.Vexenat JA, Olliaro PL, Fonseca <strong>de</strong> Castro JA, Cavalcante<br />

R, Furtado-Campos JH, Tavares JP et al. Clinical<br />

recovery and limited cure in canine visceral leishmaniasis<br />

20<br />

treated with aminosidine (paromomycin). Am J Trop Med<br />

Hyg 1998;58:448-453.<br />

14.You X, Schinazi RF, Arrowood MJ, Lejkowski M,<br />

Juodawlkis AS, Mead JR. In-vitro activities of<br />

paromomycin and lasalocid evaluated in combination<br />

against Cryptosporidium parvum. J Antimicrob Chemother<br />

1998;41:293-296.<br />

15.Awadalla HN, el Gowhary SH, Sadaka HA, Khalifa AM.<br />

Aminosidine sulphate in experimental giardiasis. J<br />

Egyptian Soc Parasitol 1995;25:53-61.<br />

16.Gordts B, De Jonckeere J, Kasprzak W, Mejewska AC,<br />

Butzler JP. In vitro activity of antiprotozoal drugs against<br />

Giardia intestinalis of human origin. Antimicrobiol Agents<br />

Chemother 1987;31:672-673.<br />

17.Edlind TD. Susceptibility of Giardia lamblia to<br />

aminiglycosi<strong>de</strong> protein synthesis inhibitors: Correlation<br />

with rRNA structure. Antimicrobiol Agents Chemother<br />

1989;33:484-488.<br />

18.Boreham PFL, Phillips RE, Shepherd RW. The activity of<br />

drugs against Giardia intestinalis in neonatal mice. J<br />

Antimicrobiol Chemother 1986;18:393-398.<br />

19.Castaldo S, Capasso F. Propolis, an old remedy used in<br />

mo<strong>de</strong>rn medicine. Fitoterapia 2002;73(Suppl 1):S1-S6.<br />

20.Mirzoeva OK, Grishanin RN, Cal<strong>de</strong>r PC. Antimicrobial<br />

action of propolis and some of its components: the effects<br />

on growth, membrane potential and motility of bacteria.<br />

Microbiol Res 1997;152:239-246.<br />

21.Miyares C, Hollands I, Castenada C, Gonzalez T, Fragoso<br />

T, Curras R et al. Ensayo terapéutico con un preparado a<br />

base <strong>de</strong> propóleos “propolisina” en la giardiasis <strong>de</strong>l humano.<br />

Acta Gasteroenterol Latinoam 1988;18:195-201.<br />

22.Havsteen BH. The biochemistry and medical significance<br />

of the flavonoids. Pharmacol Ther 2002;96:67-202.<br />

23.Sa-Nunes A, Faccioli LH, Sforcin JM. Propolis:<br />

lymphocyte proliferation and IFN-gamma production. J<br />

Ethnopharmacol 2003;87:93-97.<br />

Correspon<strong>de</strong>ncia:<br />

Dr. Fi<strong>de</strong>l A. Núñez<br />

Instituto <strong>de</strong> Medicina Tropical Pedro Kourí.<br />

Autopista <strong>de</strong>l Mediodía<br />

km 6+ entre Carretera Central y Autopista<br />

<strong>de</strong> Pinar <strong>de</strong>l Río. Apartado postal 601.<br />

Ciudad <strong>de</strong> La Habana, Cuba.<br />

Teléf.: 202-06-50<br />

e-mail: fan@ipk.sld.cu

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