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Les modèles non linéaires à effets mixtes - Isped

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Estimation of the likelihood<br />

Importance sampling:<br />

ĝ N (y) = 1 N<br />

N∑<br />

j=1<br />

h(y|φ (j) ) π(φ(j) )<br />

˜π(φ (j) )<br />

Eĝ N (y) = g(y)<br />

Varĝ N (y) = O(1/N)<br />

Varĝ N (y) = 0 ⇐⇒ ˜π(φ) = p(φ|y)<br />

Then,<br />

1) Estimate the conditional mean and the conditional variance of φ<br />

(using MCMC)<br />

2) Use for ˜π a Gaussian distribution (or a mixture Gaussian/Cauchy)<br />

with these parameters<br />

Sminaire ”Statistique et Sant Publique”, Bordeaux - 8 novembre 2005, p.35

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