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Buletin de Perinatologie 3_2008 - Baza de date a revistelor ştiinţifice

Buletin de Perinatologie 3_2008 - Baza de date a revistelor ştiinţifice

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diagnostichează la peste o jumătate <strong>de</strong> pacienţi.<br />

4. ACJ în 18,8% cazuri a fost asociată cu afectarea<br />

oculară. Uveita afectează, în<strong>de</strong>osebi fetiţele (79,5%) şi în<br />

majoritatea cazurilor se constată în forma oligoarticulară<br />

(82,1%). La 12,8% copii semnele clinice ale uveitei au fost<br />

prima manifestare a bolii precedând semnele clinice <strong>de</strong><br />

afectare articulară.<br />

Bibliografia<br />

1. AARON, S, FRASeR, PA, JACKSON, JM, et.al.<br />

Sex ratio and sibchip size in juvenile rheumatoid arthritis<br />

kindreds. Arthritis Rheum, 1985, vol.28, p.753.<br />

2. ADIB, N., SILMAN., THOMSON, w. Outcome<br />

following onset of juvenile idiopathic inflammatory<br />

arthritis: II. Predictors of outcome in juvenile arthritis.<br />

Rheumatology, 2005, vol. 44, p. 1002-1007.<br />

3. ANTHONY K., SCHANBeRG L. Pediatric<br />

pain syndrome and management of pain in children and<br />

adolescents with rheumatic disease. Pediat Clin North Am,<br />

2005, vol.52, no.2, p.611-639.<br />

4. BReeDVeLD, FeRDINAND C., weISMAN,<br />

MICHAeL H., KAVANAUGH, ARTHUR F., et. al. The<br />

premier study: A multicenter, randomized, double-blind<br />

clinical trial of combination therapy with adalimumab plus<br />

methotrexat versus methotrexat alone or adalimumab alone<br />

in patients with early, agressive rheumatoid arthritis who<br />

had not had previous methotrexat treatment. Arthritis &<br />

Rheumatism, January 2006, vol. 54, no.1, p.26-37.<br />

5. CASSIDY, JT, PeTTY, Re. Juvenile rheumatoid<br />

arthritis. In: Textbook of Pediatric Rheumatology, 5 th<br />

ed.: Cassidy JT., Petty RE (Eds) W. B. San<strong>de</strong>rs Company,<br />

Phila<strong>de</strong>lphia, 2005, p.206-260.<br />

6. CATRINA, Anca Irinel, KLINT, erik af,<br />

eRNeSTAM, Sofia, et. al. Anti-tumor necrosis factor<br />

therapy increases synovial osteoprotegerin expression in<br />

rheumatoid arthritis. Arthritis & Rheumatism, January<br />

2006, vol. 54, no.1, p.76-81.<br />

7. CODReANU, CATALIN, GeORGeSCU, LIA,<br />

IVAN, DAN., et al. Poliartrita reumatoidă. Ghid <strong>de</strong> diagnosti<br />

şi tratament. Comisia <strong>de</strong> reumatologie, Bucureşti, 2002.<br />

8. FINCKH, Axel, SIMARD, Julia F., DURYeA,<br />

Jeffrey, et. al. The effectivness of anti-tumor necrosis factor<br />

therapy in preventing progressive radiographic joint damage<br />

in rheumatoid arthritis: a population – based study. Arthritis<br />

& Rheumatism, january 2006, vol. 54, no.1, p.54-59.<br />

9. MINDeN, K, NIeweRTH, M, LISTING, J, et.al.<br />

Long-term outcome in patients with juvenile idiopathic<br />

arthritis. Arthritis Rheum, 2002, vol.46, p.2392.<br />

10. PACHAM, J.C, HALL, MA. Long-term follow-up<br />

of 246 adults with juvenile idiopathic arthritis: functional<br />

outcome. Rheumatology (Oxford), 2002, vol.41, p.1428.<br />

11. PACKHAM, J. C., HALL, M. A. Long-term<br />

follow-up of 246 adults with juvenile idiopathic arthritis:<br />

2<br />

education and employment. Rheumatology, 2002, vol. 41,<br />

p. 1436-1439.<br />

12. ROSeNBeRG, A. M., CORDeIRO, D. M.<br />

Relationschip between sex and antibodies ti high mobility<br />

group proteins 1 and 2 in juvenile idiopathic arthritis. J<br />

Rheumatol, 2000, vol.27, p.2489-2493.<br />

13. SHALLeR, JG, OCHS, HD, Thomas, eD, et.al.<br />

Histcompatibility antigens in childhood-onset arthritis.<br />

Pediatr, 1976, vol.88, p.926.<br />

14. SUNAHORI, Katsue, YAMAMURA, Masahiro,<br />

YAMANA, Jiro., et al. Increased expression of receptor<br />

for advanced glycation end products by synovial<br />

tissue macrophages in rheumatoid arthritis. Arthritis &<br />

Rheumatism, january 2006, vol. 54, no.1, p.97-104.<br />

нинель ревенко<br />

КЛИНИКО-ПАРАКЛИНИЧЕСКИЕ ОСОБЕН-<br />

НОСТИ ОЛИГОАРТИКУЛЯРНОЙ фОРМЫ ЮВЕ-<br />

НИЛЬНОГО ХРОНИЧЕСКОГО АРТРИТА<br />

Целью данного исследования было выявление клинико-параклинических<br />

особенностей олигоартикулярной<br />

формы ювенильного хронического артрита. В<br />

обследование было включено 207 детей отвечающих<br />

диагностическим критериям аКр (средний возраст<br />

134,6±51,9 месяцев). Выявлено что олигоартикулярная<br />

форма ювенильного хронического артрита чаще всего<br />

дебютирует в возрасте до 5 лет, поражает в равной<br />

степени девочек и мальчиков (д/м=1,1/1,0), в большей<br />

степени патологический процес поражает коленные и<br />

голеностопные суставы, в 82,1% случаев установлено<br />

вовлечение глаз. необходимо отметить, что увеит в<br />

79,5% случаев отмечен у девочек.<br />

Ninel Revenco<br />

CLINICAL AND PARACLINICAL ASPeCTS OF<br />

THe OLIGOARTHRITIS FORM OF THe JUVe-<br />

NILe CHRONIC ARTHRITIS (JCA)<br />

The goal of this research was to <strong>de</strong>termine clinical and<br />

paraclinical aspects of oligo-arthritis form of the Juvenile<br />

Chronic Arthritis (JCA). 207 children, passing the JCA criteria<br />

(mean age of 134,6 + 51,9 months), were inclu<strong>de</strong>d in<br />

the research. In accordance with the questions of the special<br />

protocol, the following specifics of oligoarthritis form of<br />

JCA were analyzed: <strong>de</strong>but age, gen<strong>de</strong>r ratio, specifics of the<br />

joint syndrome, disease activity score according to the DAS<br />

in<strong>de</strong>x. As a result of the research, it was <strong>de</strong>termined that<br />

the oligoarthritis form of JCA most often appears initially<br />

before the age of 5, strikes boys and girls equally often<br />

(G/B=1,1/1,0), and that the pathologic process affects the<br />

knee joint at a higher <strong>de</strong>gree. In 82,1% of the cases it also<br />

damages the eyesight. It is important to note, that uveitis is<br />

found in 79,5% of cases among girls.<br />

Recepţionat 16.06.<strong>2008</strong>

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