Therapeutische Hypothermie (TH) - Repository of the LBI-HTA ...

4.1.1 Herz-Kreislauf-Stillstand
Tabelle 4.1-2 zeigt Charakteristika und Ergebnisse des eingeschlossenen
Cochrane Reviews [23] zur therapeutischen Hypothermie nach Herz-
Kreislauf-Stillstand.
Tabelle 4.1-2: Included systematic review of therapeutic hypothermia in patients successfully resuscitated after cardiac
arrest
Author, year, reference number Arrich (2009) [23]
Country
AT
Sponsor
- unrestricted scientific grant to the Medical University of Vienna
from Alsius Corporation
- travel grants from Alsius Corporation and Kinetic Concepts, Inc (KCI)
- honoraria for lectures from Medivance and KCI
Indication
adult patients (≥18 yrs) who were successfully resuscitated after cardiac
arrest (in-hospital or out-of –hospital)
Intervention
Therapeutic hypothermia
- applied within 6 hours of arrival at hospital
- regardless of method
- any body target temperature below 35°C
Control
standard treatment
Study design
SR + MA
Last date searched 01/2007
Included studies
RCTs and quasi-randomised controlled trials
Number of included studies 5 (4 trials, 1 abstract)
Number of included patients 481
Outcomes
Primary
Neurological recovery: good neurological
RR 95% CI I 2 P
outcome 7
- total (5 studies/ 479 pts) 1.55 1.24, 1.94 57% 8 0.00012
- conventional cooling (3 studies/
1.55 1.22, 1.96 32% 0.00027
383 pts)
- cooling with haemofiltration 0.71 0.32, 1.54 NA 0.38
(1 study/ 42 pts)
- unknown method of cooling
(1 study/ 54 pts)
4.5 1.17, 17.30 NA 0.029
7 Good neurological outcome defined as cerebral performance categories (CPC) of
one or two (CPC five point scale; 1 = good cerebral performance to 5 = brain
death)
8 Statistical heterogeneity was considered relevant if I 2 (percentage of total variation
across studies due to heterogeneity) was >50%. In this case, clinical heterogeneity
was due to different cooling methods.
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