Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...

assume that all participants knew of their allocation. Four studies reported complete
follow-up of participants. 99,104-106
Table 62 Methodological quality of included studies focusing on the use of HBOT in head and neck
cancer.*
First Author and Year of
Publication
Study Design Randomisation Masking
Losses to
Follow-up
Whittle 1990 99 Comparative study None None No losses
Henk 1986 100 RCT Unclear None One patient
Sealy 1986 101 RCT Unclear None Six patients
Berry 1979 102
RCT
Unclear None
Two patients
from HBO
group (treated
in air)
Sause 1979 103 RCT Unclear None Six patients
Chang 1973 104 RCT Unclear None No losses
Churchill-Davidson 1973 105
Shigamatsu 1973 106
Henk 1970 107
Comparative study
with historical
controls
Pseudorandomised
controlled trial
Pseudorandomised
controlled trial
* Abbreviation: RCT = randomised controlled trial.
None None No losses
Odd and even
admission numbers
Allocation by birth
date for first 52
cases, subsequent
cases by sealed
envelopes
None No losses
Hyperbaric oxygen therapy 63
None
Eighteen
patients
received less
than half their
treatment in the
HBOT group.
Patient criteria
Table 63 compares the various patient criteria used for enrolment into the identified
studies. Although all studies recruited patients with cancer of the head and neck regions,
Whittle et al99 included patients with glottic cancer only and Shigamatsu et al106 limited
enrolment to patients with maxillary sinus cancer. The remainder of the studies varied in
their description of the location of carcinomas in their study populations.