Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...

Table 68 Therapeutic protocols used in intervention and comparison groups in included studies
focusing on the use of HBOT in cervical cancer.*
First Author
and Year
of Publication
Intervention Group Comparison Group
Brady 1981 108
Watson
1978 109
Fletcher
1977 110
n=29
Stage IIb: 4,000 rad tumour dose in 10 fractions
over five weeks. Gynaecological radium dose
from 3,000 to 4,500 mg-hrs. No boosters given.
Stage IIIa: 4,000 rad tumour dose in 10 fractions
over five weeks. Gynaecological radium dose
from 3,000 to 4,000 mg-hrs. Booster to site of 400
rad per fraction. Vaginal extensions treated
according to investigator.
Stage IIIb and IVa: 4,000 rad tumour dose in 10
fractions over 5 weeks. Gynaecological radium
dose from 3,000 to 4,500 mg-hrs. Booster to site
of 400 rad per fraction. Vaginal extensions treated
according to investigator.
Treatment in an unstated HBO chamber at 3 ATA
for 60 minutes.
n=150
Comparison therapy plus HBOT. †
n=109
Comparison therapy plus treatment in a
monoplace HBO chamber with oxygen. †
n=29
Stage IIb: 5,000 rad tumour dose in 25 fractions
over five weeks. Gynaecological radium dose
from 3,000 to 4,500 mg-hrs. No boosters given.
Stage IIIa: 5,000 rad tumour dose in 25 fractions
over five weeks. Gynaecological radium dose
from 3,000 to 4,000 mg-hrs. Booster to site of 500
rad per 2 fractions. Vaginal extensions treated
according to investigator.
Stage IIIb and IVa: 5,000 rad tumour dose in 25
fractions over 5 weeks. Gynaecological radium
dose from 3,000 to 4,500 mg-hrs. Booster to site
of 500 rad per 2 fractions. Vaginal extensions
treated according to investigator.
n=151
Multicentre trial allowing variations in radiotherapy
protocols. Maximal dose varied between centres
with some prescribing maximum doses of 3,000
rad and others giving a minimum of 5,500 rad.
Fractions varied from 6 to 27 doses. Radium
applied to some patients.
n=124
Stage IIb: node negative – 4,000 rad tumour dose
for four weeks through 15 × 15 cm fields; node
positive – 5,500 rad tumour dose in 6.5 weeks at
850 rad per week with appropriate field extension.
External beam followed by two radium
applications for 48 hours each, two weeks apart,
to a maximum of 6,500 mg-hrs.
Stage IIIa: node negative – 5,000 rad tumour
dose for five weeks through 15 × 15 cm fields;
node positive – 5,500 rad tumour dose at 850 rad
per week with ipsilateral parametrial boost of
1,000 rad in one week. External beam followed by
two radium applications (24 and 48 hours for first
and second applications, respectively) to a
maximum of 5,000 mg-hrs.
Stage IIIb and IVa: 5m000 to 5,500 rad tumour
dose with field reduction to 12 × 12 cm for
additional 1,000 rad. Single radium application for
60 hours not to exceed 4,000 mg-hrs.
External irradiation schedules listed.
Hyperbaric oxygen therapy 69