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A Current Bibliography on African Affairs - Baywood Publishing

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VOLUME 42, NUMBER 4—2009-2010 / 383<br />

pharmaceutical ingredient c<strong>on</strong>tent against internati<strong>on</strong>ally acceptable standards. The high<br />

persistence of substandard drugs and clinically inappropriate artemisinin m<strong>on</strong>otherapies in<br />

the private sector risks patient safety and, through drug resistance, places the future of<br />

malaria treatment at risk globally.<br />

1268. Beck, I. A. et al. OPTIMIZATION OF THE OLIGONUCLEOTIDE LIGATION<br />

ASSAY, A RAPID AND INEXPENSIVE TEST FOR DETECTION OF HIV-1 DRUG<br />

RESISTANCE MUTATIONS, FOR NON-NORTH AMERICAN VARIANTS. Journal of<br />

Acquired Immune Deficiency Syndromes. 2008, 48(4):418-427.<br />

We evaluated the feasibility of olig<strong>on</strong>ucleotide ligati<strong>on</strong> assay (OLA), a specific, sensitive,<br />

and ec<strong>on</strong>omical ligase-based point mutati<strong>on</strong> assay designed to detect HIV-1 drugresistance<br />

mutati<strong>on</strong>s at 12 cod<strong>on</strong>s of HIV-1 subtype B pol, for potential use in resourcepoor<br />

settings. The OLA designed for HIV-1 subtype B genotyped most pol cod<strong>on</strong>s in n<strong>on</strong>-B<br />

subtypes from Asia and Africa but was improved by additi<strong>on</strong> of several modified probes.<br />

Internati<strong>on</strong>al laboratories experienced in molecular techniques were able to perform<br />

the OLA.<br />

1269. Begley, E. B. et al. WILLINGNESS OF MEN WHO HAVE SEX WITH MEN<br />

(MSM) IN THE UNITED STATES TO BE CIRCUMCISED AS ADULTS TO REDUCE<br />

THE RISK OF HIV INFECTION. PLoS ONE. 2008, 3(7):e2731.<br />

Circumcisi<strong>on</strong> reduces HIV acquisiti<strong>on</strong> am<strong>on</strong>g heterosexual men in Africa, but it is<br />

unclear if circumcisi<strong>on</strong> may reduce HIV acquisiti<strong>on</strong> am<strong>on</strong>g men who have sex with men<br />

(MSM) in the United States, or whether MSM would be willing to be circumcised if<br />

recommended. Over half of uncircumcised MSM, especially black MSM, expressed<br />

willingness to be circumcised. Perceived risks and benefits of circumcisi<strong>on</strong> should be a part<br />

of educati<strong>on</strong>al materials if circumcisi<strong>on</strong> is recommended for MSM in the United States.<br />

1270. Bekibele, C. O., and O. Gureje. SELF-REPORTED VISUAL IMPAIRMENT<br />

AND IMPACT ON VISION-RELATED ACTIVITIES IN AN ELDERLY NIGERIAN<br />

POPULATION: REPORT FROM THE IBADAN STUDY OF AGEING. Ophthalmic<br />

Epidemiology. 2008, 15(4):250-256.<br />

Studies have shown an associati<strong>on</strong> between visual impairment and poor overall functi<strong>on</strong>.<br />

Studies from Africa and developing countries show high prevalence of visual impairment.<br />

More informati<strong>on</strong> is needed <strong>on</strong> the community prevalence and impact of visual impairment<br />

am<strong>on</strong>g elderly <strong>African</strong>s. The prevalence of self-reported distant visual impairment was<br />

high but that for near visual impairment was less than expected in this elderly <strong>African</strong><br />

populati<strong>on</strong>. Impairment of near visi<strong>on</strong> was found to carry with it a higher burden of<br />

functi<strong>on</strong>al disability than that of distant visi<strong>on</strong>.<br />

1271. Bell, C. C. et al. BUILDING PROTECTIVE FACTORS TO OFFSET SEX-<br />

UALLY RISKY BEHAVIORS AMONG BLACK YOUTHS: A RANDOMIZED CON-<br />

TROL TRIAL. Journal of the Nati<strong>on</strong>al Medical Associati<strong>on</strong>. 2008, 100(8):936-944.<br />

We test the effectiveness of the CHAMP am<strong>on</strong>g black South <strong>African</strong>s in KwaZulu-Natal,<br />

South Africa. CHAMPSA enhances a significant number of individual, family and community<br />

protective factors that can help youths avoid risky behaviors leading to HIVpositive<br />

status.

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