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Parasites and Biliary stones

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Endoscopic retrograde cholangiopancreatography ١٢١<br />

Endoscopic biopsy:<br />

Biopsies can be taken in the st<strong>and</strong>ard endoscopic manner. However,<br />

biopsies can also be taken from both the biliary <strong>and</strong> pancreatic ducts at<br />

ERCP under fluoroscopic guidance or under direct vision using the<br />

"mother <strong>and</strong> baby" choledochoscope. Although forceps, particularly<br />

pediatric forceps, can be advanced directly through the papilla, a<br />

sphincterotomy is usually necessary before passing the biopsy forceps<br />

into the biliary or pancreatic duct (figure 24) (Lee <strong>and</strong> Leung, 1998).<br />

Any attempt to obtain deeper cytological specimens is desirable with<br />

ductal pathology, as tumors can be extrinsic, submucosal, or associated<br />

with a significant desmoplastic reaction. There is higher sensitivity for<br />

cancer detection for forceps biopsy than brush cytology (81% versus<br />

48%). Taking more biopsies may also increase the diagnostic yield, <strong>and</strong><br />

probably three or four biopsies should be taken (Kubota et al., 1993).<br />

Figure (24): Radiographic image of an open biopsy forceps within the common bile<br />

duct (Byrne <strong>and</strong> Jowell, 2003)

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