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Parasites and Biliary stones

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Treatment of calcular obstructive jaundice ٨٠<br />

Treatment of calcular obstructive jaundice<br />

Role of medical therapy:<br />

Ursodeoxycholic acid (10 mg/kg) eliminated gallbladder<br />

microlithiasis <strong>and</strong> reduced the episodes of further pancreatitis. Continuing<br />

therapy with UDCA appeared to prevent recurrence of gallbladder<br />

microlithiasis (Ros et al., 1991). Its benefit in patient who cannot<br />

undergo surgery <strong>and</strong> may work best on solitary <strong>stones</strong> less than 2 cm in<br />

diameter. These treatment are now considered adjuncts to surgery rather<br />

than alternatives. Overall, results are poor compared with the<br />

interventions described below (Kelly et al., 2000).<br />

Patients with cholangitis or gallstone pancreatitis are acutely ill, <strong>and</strong><br />

they often require aggressive rehydration. Antibiotics are indicated if<br />

infection is present, <strong>and</strong> complete bowel rest (nothing by mouth,<br />

nasogastric intubation) may be necessary. The patient may require<br />

correction of coagulopathy, especially when an intervention is planned<br />

(Halpin <strong>and</strong> Soper, 2001).<br />

ERCP (sphincterotomy or pneumatic dilatation):<br />

Endoscopic biliary sphincterotomy (ES) at ERCP was first described<br />

in 1974 <strong>and</strong> was initially advocated for elderly patients or patients with<br />

other co-morbid illness excluding them from surgical management.<br />

However, since this time, ES has become widespread in the practice for<br />

the removal of choledocholithiasis. The use of ES, particularly in younger<br />

patients, led to concern over the long term sequelae of a disrupted<br />

sphincter of Oddi caused by chronic enteric-biliary reflux (Tham et al.,<br />

1997).

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