Lung Cancer.pdf

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Treatment of Early-Stage Non–Small Cell Carcinoma of the Lung 117 Siegenthaler MP, Pisters KM, Merriman KW, et al. Preoperative chemotherapy for lung cancer does not increase surgical morbidity. Ann Thorac Surg 2001;71: 1111–1112. Takizawa T, Terashima M, Koike T, et al. Lymph node metastasis in small peripheral adenocarcinoma of the lung. J Thorac Cardiovasc Surg 1998;116:276–280.
7 SURGICAL TREATMENT OF LOCALLY ADVANCED NON–SMALL CELL LUNG CANCER Stephen G. Swisher Chapter Overview ....................................................................................... 118 Introduction ................................................................................................. 119 Treatment Options for Locally Advanced Non–Small Cell Lung Cancer .............................................................. 120 Initial Assessment of Patients with Locally Advanced Disease ........... 122 Treatment of Patients with Stage IIIA Disease ........................................ 123 T3N1 Disease .......................................................................................... 123 Selection of Therapy ......................................................................... 126 Operative Strategy ............................................................................ 127 Non-Pancoast Tumors ................................................................ 127 Pancoast Tumors ......................................................................... 129 Postoperative Treatment .................................................................. 130 T1–3N2 Disease ..................................................................................... 130 Selection of Therapy ......................................................................... 131 Operative Strategy ............................................................................ 132 Postoperative Treatment .................................................................. 133 Treatment of Patients with Stage IIIB Disease ........................................ 134 Selection of Therapy .............................................................................. 134 Operative Strategy ................................................................................. 135 Postoperative Treatment ....................................................................... 138 Future Directions ......................................................................................... 138 Acknowledgement ...................................................................................... 138 Key Practice Points ..................................................................................... 139 Suggested Readings .................................................................................... 139 Chapter Overview Locally advanced (stage IIIA and IIIB) non–small cell lung cancer (NSCLC) includes a heterogeneous group of tumor types. The overall survival rate
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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Page 103 and 104: Figure 5-2. Patient “pathway to r
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Page 111 and 112: 98 Y. De Jesus and G.L. Walsh KEY P
Page 113 and 114: 100 Y. De Jesus and G.L. Walsh Jenn
Page 115 and 116: 102 W.R. Smythe nation for these su
Page 117 and 118: 104 W.R. Smythe patient reports of
Page 119 and 120: 106 W.R. Smythe bar or limited lung
Page 121 and 122: 108 W.R. Smythe hospitals for 149 p
Page 123 and 124: 110 W.R. Smythe Figure 6-1. Postsur
Page 125 and 126: 112 W.R. Smythe nant neoplasms has
Page 127 and 128: 114 W.R. Smythe Future Directions F
Page 129: 116 W.R. Smythe Henschke CI, McCaul
Page 133 and 134: 120 S.G. Swisher Treatment Options
Page 135 and 136: 122 S.G. Swisher Initial Assessment
Page 137 and 138: 124 S.G. Swisher Figure 7-1. Region
Page 139 and 140: 126 S.G. Swisher Table 7-2. (contin
Page 141 and 142: 128 S.G. Swisher upper paratracheal
Page 143 and 144: 130 S.G. Swisher is performed only
Page 145 and 146: 132 S.G. Swisher chance for long-te
Page 147 and 148: 134 S.G. Swisher Pancoast tumors th
Page 149 and 150: 136 S.G. Swisher A B Figure 7-2. Do
Page 151 and 152: 138 S.G. Swisher a combination of t
Page 153 and 154: 140 S.G. Swisher Dartevelle PG, Cha
Page 155 and 156: 8 NONSURGICAL TREATMENT OF EARLY-ST
Page 157 and 158: 144 R. Komaki morbid conditions pre
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Page 161 and 162: 148 R. Komaki Around 1998, by using
Page 163 and 164: 150 R. Komaki Table 8-5. Survival a
Page 165 and 166: 152 R. Komaki A total of 610 patien
Page 167 and 168: 154 R. Komaki tially obstructed air
Page 169 and 170: 156 R. Komaki report of Radiation T
Page 171 and 172: 9 TREATMENT OF PATIENTS WITH ADVANC
Page 173 and 174: 160 R. Zinner chemotherapy, in pati
Page 175 and 176: Table 9-1. Chemotherapy in Older Pa
Page 177 and 178: 164 R. Zinner results of additional
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Table 9-4. Third-Generation Agents
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Table 9-5. Third-Generation Platinu
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Table 9-6. Comparisons between Diff
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174 R. Zinner may play an important
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Table 9-8. Third-Generation Cisplat
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178 R. Zinner wards higher survival
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180 R. Zinner KEY PRACTICE POINTS
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182 R. Zinner DeVore RF, Fehrenbach
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184 R. Zinner Perng RP, Chen YM, Mi
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10 TREATMENT OF LIMITED-STAGE SMALL
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188 R. Komaki Age is not a signific
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190 R. Komaki lished between 1979 a
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Table 10-1. Complete Response Rates
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194 R. Komaki twice daily to a tota
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196 R. Komaki Intergroup study 0096
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198 R. Komaki Figure 10-1. Survival
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200 R. Komaki cisplatin with concur
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202 R. Komaki KEY PRACTICE POINTS
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204 R. Komaki tients (Pts) with lim
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206 R. Komaki Wagner H, Kim K, John
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208 G.R. Blumenschein, Jr. recurs a
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210 G.R. Blumenschein, Jr. syndrome
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212 G.R. Blumenschein, Jr. toxicity
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214 G.R. Blumenschein, Jr. the year
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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258 E.S. Kim and F.R. Khuri A secon
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260 E.S. Kim and F.R. Khuri Smoking
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262 E.S. Kim and F.R. Khuri Reversa
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264 E.S. Kim and F.R. Khuri yet to
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266 E.S. Kim and F.R. Khuri nation
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268 E.S. Kim and F.R. Khuri Methodo
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270 E.S. Kim and F.R. Khuri have be
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272 E.S. Kim and F.R. Khuri the tre
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274 E.S. Kim and F.R. Khuri changes
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276 E.S. Kim and F.R. Khuri KEY PRA
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278 E.S. Kim and F.R. Khuri Hong WK
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15 MOLECULAR EVENTS IN LUNG CANCER
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282 W.N. Hittelman, J.M. Kurie, and
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300 Index Anterior spinal column re
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302 Index Cardiac murmurs, 104 Card
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304 Index Diagnosis. See also under
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306 Index Growth. See Tumor growth
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308 Index Magnetic resonance (MR) i
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310 Index p16 gene, 285 p19 arf gen
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312 Index Pulmonary resection (cont
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314 Index Squamous metaplasia, 263-
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316 Index Vitamin A, 262 Vocal cord
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