Lung Cancer.pdf

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Index 311 NSCLC, 109, 159-160, 160-161 patient age and, 161 practice guidelines, 87-88 SCLC, 210 second-generation agents and, 170-173 TAX 317 study, 177 TAX 320 study, 177 third-generation agents and, 164-174, 170-173 Pleomorphic carcinomas, 75 Pleural catheters, chronic indwelling, 20, 230-236 Pleural effusion at diagnosis, 7 diagnostic thoracentesis, 32 malignant, 228-234 NSCLC patients, 43, 45 practice guidelines, 87 recurrent, 228 SCLC and, 188 Pleural flaps, 252 Pleurodesis, 229 Pleurx catheters, 230-236 Pneumocytes, 76-77 Pneumonia, 7, 27, 209 Pneumonitis, 201, 246-247 Pneumothorax, 42-43 Polypeptide hormones, 209 Positron emission tomography (PET) coronal whole-body, 49-50 mediastinal lymph nodes, 12 NSCLC, 104 pretreatment evaluation, 15, 31, 112 SCLC, 188 screening, 277 Postoperative evaluation, 62, 223 Postoperative management, 110-111 Posttreatment evaluation, 51-53 Practice guidelines, 189, 224-225 Precancerous lesions, 62-68, 261 Preinvasive lesions, 62-68, 261 Pretreatment evaluation history, 10-11 for NSCLC, 103-105, 122-123, 143, 160, 164 palliative care, 221-223 pathology, 60-61 physical examination, 10-11 radiographic imaging, 29-31 for SCLC, 188-189, 208-209 staging, 8-15 thoracic surgery, 249-250 Prevascular lymph nodes, 124, 125 Prevention, 37 Primary tumors metastases distinguished from, 76-77 second, 269-270 Prognosis, implications of molecular changes for estimating, 291-292 Prognostic factors for SCLC, 187-188, 209 Prophylactic cranial irradiation (PCI), 135, 188, 198-200. See also Brain; Radiation therapy Prostaglandins, 265, 266 Prostate cancer, 5 Protein kinase C alpha, 179 Pruritus, 245 Pulmonary arteries, 237, 251 Pulmonary arterioplasty, 227 Pulmonary artery sleeve resection, 227 Pulmonary blastomas, 75 Pulmonary function testing, 32, 105, 228. See also entries for specific measures Pulmonary insufficiency, 227 Pulmonary ligament lymph nodes, 124, 125 Pulmonary lymph nodes, 6 Pulmonary resection artery sleeve, 227 clinical pathways, 89-97
312 Index Pulmonary resection (continued) limited versus full, 106-107 surgical strategy, 128-129 thoracoscopic, 106 Pulmonary reserves, 122-123 Pulmonary tents, 251-252 Pulmonary toxicity, 244 Quality of life assessment tools, 222 brain metastases, 224 chemotherapy and, 163 selection of agents and, 164 surgical improvement, 19-20 R115777, 273 Radiation doses, maximum, 249 Radiation therapy acute side effects, 245-248 assessment of patients after, 36 chemotherapy and. See Chemoradiation therapy complications, 17 doses, maximum, 249 external-beam, 225 Horner’s syndrome, 153 hyperfractionated, 149, 150, 195-197 multidisciplinary treatment and, 244 NSCLC, 17, 20, 105, 107-108 for pain management, 225, 226 postoperative, 138, 246-247 practice guidelines, 89 preoperative, 247 prophylactic, 135, 188, 198-200 RTOG 94-10, 151-152 stage I NSCLC lesions, 142-146 stage II NSCLC lesions, 147-148 stage III NSCLC lesions, 147-148 suggested maximum doses, 249 superior sulcus tumors, 152-153 surgery versus, 107-108 target volumes, 144-145 tissue integrity and, 251 Radiation Therapy Oncology Group (RTOG), 198 83-11 trial, 147 88-08 trial, 148, 149 91-06 trial, 149 92-04 trial, 149-151 93-09 trial, 131-132 93-11 trial, 145 94-10 trial, 151-152, 244 Intergroup study 0096, 196 SCLC and, 191 Radiographic imaging. See also entries for specific technologies adrenal metastases, 27 assessment after treatment, 36 chest, 11, 29 diagnostic, 7, 29-31 estimation of growth, 39-40 evaluation of response to treatment, 51 future trends, 97-99 NSCLC, 104 pretreatment evaluation, 11-12 SCLC, 188 Radiopharmaceuticals, 225 Radon, 6, 282 Raf genes, 284 RAS genes, 273-274 Ras mutations, 292-294 RASSF1A genes, 285 Reactive alveolar epithelial hyperplasia, 66 Reactive hyperplasia, 30 Readmission rates, 95 Recovery rooms, 93 Recurrent disease limited resection and, 106-107 NSCLC, 52 SCLC, 215-217 T1–3N2 tumors, 132, 133 Recurrent nerves, 6 Reducing Tobacco Use: A Report of the Surgeon General, 259
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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66 P. Tamboli and J.Y. Ro Atypical
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68 P. Tamboli and J.Y. Ro Diffuse I
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70 P. Tamboli and J.Y. Ro noma. Cig
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72 P. Tamboli and J.Y. Ro Figure 4-
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74 P. Tamboli and J.Y. Ro alone. BA
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76 P. Tamboli and J.Y. Ro Other Mal
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78 P. Tamboli and J.Y. Ro Electron
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80 P. Tamboli and J.Y. Ro Niho S, Y
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82 Y. De Jesus and G.L. Walsh Chapt
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84 Y. De Jesus and G.L. Walsh Figur
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86 Y. De Jesus and G.L. Walsh guide
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88 Y. De Jesus and G.L. Walsh with
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Figure 5-2. Patient “pathway to r
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94 Y. De Jesus and G.L. Walsh Recov
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98 Y. De Jesus and G.L. Walsh KEY P
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100 Y. De Jesus and G.L. Walsh Jenn
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102 W.R. Smythe nation for these su
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104 W.R. Smythe patient reports of
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106 W.R. Smythe bar or limited lung
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108 W.R. Smythe hospitals for 149 p
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110 W.R. Smythe Figure 6-1. Postsur
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112 W.R. Smythe nant neoplasms has
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114 W.R. Smythe Future Directions F
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116 W.R. Smythe Henschke CI, McCaul
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7 SURGICAL TREATMENT OF LOCALLY ADV
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120 S.G. Swisher Treatment Options
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122 S.G. Swisher Initial Assessment
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124 S.G. Swisher Figure 7-1. Region
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126 S.G. Swisher Table 7-2. (contin
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128 S.G. Swisher upper paratracheal
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130 S.G. Swisher is performed only
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132 S.G. Swisher chance for long-te
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134 S.G. Swisher Pancoast tumors th
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136 S.G. Swisher A B Figure 7-2. Do
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138 S.G. Swisher a combination of t
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140 S.G. Swisher Dartevelle PG, Cha
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8 NONSURGICAL TREATMENT OF EARLY-ST
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144 R. Komaki morbid conditions pre
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146 R. Komaki and 26 patients had c
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148 R. Komaki Around 1998, by using
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150 R. Komaki Table 8-5. Survival a
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152 R. Komaki A total of 610 patien
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154 R. Komaki tially obstructed air
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156 R. Komaki report of Radiation T
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9 TREATMENT OF PATIENTS WITH ADVANC
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160 R. Zinner chemotherapy, in pati
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Table 9-1. Chemotherapy in Older Pa
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164 R. Zinner results of additional
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Table 9-3. Third-Generation-Agent M
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Table 9-4. Third-Generation Agents
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Table 9-5. Third-Generation Platinu
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Table 9-6. Comparisons between Diff
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174 R. Zinner may play an important
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Table 9-8. Third-Generation Cisplat
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178 R. Zinner wards higher survival
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180 R. Zinner KEY PRACTICE POINTS
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182 R. Zinner DeVore RF, Fehrenbach
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184 R. Zinner Perng RP, Chen YM, Mi
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10 TREATMENT OF LIMITED-STAGE SMALL
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188 R. Komaki Age is not a signific
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190 R. Komaki lished between 1979 a
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Table 10-1. Complete Response Rates
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194 R. Komaki twice daily to a tota
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196 R. Komaki Intergroup study 0096
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198 R. Komaki Figure 10-1. Survival
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200 R. Komaki cisplatin with concur
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202 R. Komaki KEY PRACTICE POINTS
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204 R. Komaki tients (Pts) with lim
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206 R. Komaki Wagner H, Kim K, John
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208 G.R. Blumenschein, Jr. recurs a
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210 G.R. Blumenschein, Jr. syndrome
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212 G.R. Blumenschein, Jr. toxicity
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214 G.R. Blumenschein, Jr. the year
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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258 E.S. Kim and F.R. Khuri A secon
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Page 295 and 296: 282 W.N. Hittelman, J.M. Kurie, and
Page 313 and 314: 300 Index Anterior spinal column re
Page 315 and 316: 302 Index Cardiac murmurs, 104 Card
Page 317 and 318: 304 Index Diagnosis. See also under
Page 319 and 320: 306 Index Growth. See Tumor growth
Page 321 and 322: 308 Index Magnetic resonance (MR) i
Page 323: 310 Index p16 gene, 285 p19 arf gen
Page 327 and 328: 314 Index Squamous metaplasia, 263-
Page 329: 316 Index Vitamin A, 262 Vocal cord
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