Lung Cancer.pdf

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Index 309 Mortality rates, 4, 95, 96, 119, 221 Mucoepidermoid carcinomas, 76 Multidisciplinary care chemotherapy in, 247-248 complex tumors, 19 implementation, 1-24 NSCLC, 121 pathway design, 89-97 radiation therapy in, 247-248 superior sulcus tumors, 226 team approach, 16 Multimodality therapy, 241-255, 253-254 Multistep model of carcinogenesis, 259, 283-284 MYC genes, 15, 273 Myelitis, 17, 248 Myelosuppression, 167 Myocardial infarction, 143 Narcotics, 245, 248 National Cancer Institute (NCI), 191, 199-200, 269-270 National Cancer Institute of Canada Clinical Trials Group, 194-195 National Cancer Institute Surveillance, Epidemiology and End Results Program, 102 National Comprehensive Cancer Network (NCCN), 86, 189, 224-225 National Health and Nutrition Examination Survey, 266 Necrosis, tumor, 51 Neovastat, 296 Neu oncogene, 15. See also HER-2/neu oncogene Neuroendocrine markers, 77 Neuroendocrine tumors of the lung, 69-70 Neurological symptoms, 14 Neurotoxicity, 167, 199 Neutropenia, 161 Neutropenic fever, 201 Neutrophil counts, 250 Nickel, 6 Nitrosamines, 259 Nodular type II pneumocyte hyperplasia, 66 Non-Pancoast tumors, 121, 126-130, 138 Non-Small Cell Lung Cancer Collaborative Group, 108-109 Non-small cell lung cancer (NSCLC). See entries for specific topics Nonepithelial tumors, WHO classification, 65 Nonmucinous bronchioalveolar adenocarcinoma (BAC), 66-67 Nuclear morphometry, 66 Nutritional status, 201, 223-224, 237-238 Nutritional support, 246, 250 Obstipation, 246 Occlusive dressings, 245 Odynophagia, 245 Oncogenes, 15, 284. See also entries for specific genes ONYX-015, 272, 295 Opacities, evaluation of, 38 Operating room, clinical pathways, 93 Opioids, 225, 246 Organic chemicals, 6, 282 OSI-774 (Tarceva), 179 Osteolysis, 6 Osteosarcomas, 39, 75 Ototoxicity, 167 Outcomes analysis, 94-96 Outcomes documentation, 89 Outpatient clinic visits, 91 Oxycodone, 245 Oxygen consumption testing, 32, 122, 228
310 Index p16 gene, 285 p19 arf gene, 285 p53 gene carcinogens and, 286 cell growth and, 285 defective, 294-295 gene therapy, 271-273 immunohistochemical staining, 78 mutations in atypical adenomatous hyperplasia, 66 prognosis and, 291 tumor growth and, 15 Paclitaxel advanced NSCLC, 161 best supportive care and, 165 carboplatin and, 163 cisplatin and, 168 extensive-stage SCLC, 210, 216 NSCLC, 18 platinum-based regimens and, 178 preoperative, 109-110 quality of life and, 164 Pain management families, 225 metastases and, 104 oral medication, 111 palliative care and, 222 quality of life and, 224-225 radiographic evaluation of, 31 upper right quadrant, 27 Palliative care, 220-224 advanced NSCLC, 161 alimentation and nutrition, 237-238 approaches, 223-237 constitutional symptoms, 223-224 extensive-stage SCLC, 217 radiographic evaluation, 31 surgical, 20 symptoms and, 223-237 Pancoast tumors, 44, 121, 129-130, 137-138 Papillary growth, 66 Papillomas, 63 Para-aortic lymph nodes, 124, 125 Paraneoplastic syndromes, 28-29, 188, 209 Partial pressure of oxygen, 143 Pathology evaluation, 57-80 molecular events, 280-298 SCLC workup, 188 Patient-controlled analgesia, 91 Patient education clinical pathways, 89, 90, 91 day of surgery, 92 on discharge, 111 Patient identifiers, 91 Pedicled flaps, 253 Performance status. See also entries for specific measurement tools advanced NSCLC survival and, 160 extensive-stage SCLC, 209 fitness for surgery, 143 patient evaluation, 221-223 SCLC outcomes and, 187 Perfusion, 40-42, 105 Pericardium, 6 Phosphoinositide 3-kinase (PI3K), 284, 294 Phrenic nerves, 6, 7 Physical examination, 10-11, 26-29, 103-105 Physician orders, preprinted, 84-85, 89 Physician profiling, 96 Physicians Health Study, 269 Pituitary, anterior, 76-77 Planning target volume (PTV), 144-145 Platinum-based regimens. See also entries for specific drugs EORTC 8975 study, 175 GEPC 98-02 study, 175, 176 neoadjuvant, 18
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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66 P. Tamboli and J.Y. Ro Atypical
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68 P. Tamboli and J.Y. Ro Diffuse I
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70 P. Tamboli and J.Y. Ro noma. Cig
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72 P. Tamboli and J.Y. Ro Figure 4-
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74 P. Tamboli and J.Y. Ro alone. BA
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76 P. Tamboli and J.Y. Ro Other Mal
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78 P. Tamboli and J.Y. Ro Electron
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80 P. Tamboli and J.Y. Ro Niho S, Y
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82 Y. De Jesus and G.L. Walsh Chapt
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84 Y. De Jesus and G.L. Walsh Figur
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86 Y. De Jesus and G.L. Walsh guide
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88 Y. De Jesus and G.L. Walsh with
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Figure 5-2. Patient “pathway to r
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94 Y. De Jesus and G.L. Walsh Recov
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98 Y. De Jesus and G.L. Walsh KEY P
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100 Y. De Jesus and G.L. Walsh Jenn
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102 W.R. Smythe nation for these su
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104 W.R. Smythe patient reports of
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106 W.R. Smythe bar or limited lung
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108 W.R. Smythe hospitals for 149 p
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110 W.R. Smythe Figure 6-1. Postsur
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112 W.R. Smythe nant neoplasms has
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114 W.R. Smythe Future Directions F
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116 W.R. Smythe Henschke CI, McCaul
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7 SURGICAL TREATMENT OF LOCALLY ADV
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120 S.G. Swisher Treatment Options
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122 S.G. Swisher Initial Assessment
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124 S.G. Swisher Figure 7-1. Region
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126 S.G. Swisher Table 7-2. (contin
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128 S.G. Swisher upper paratracheal
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130 S.G. Swisher is performed only
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132 S.G. Swisher chance for long-te
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134 S.G. Swisher Pancoast tumors th
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136 S.G. Swisher A B Figure 7-2. Do
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138 S.G. Swisher a combination of t
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140 S.G. Swisher Dartevelle PG, Cha
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8 NONSURGICAL TREATMENT OF EARLY-ST
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144 R. Komaki morbid conditions pre
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146 R. Komaki and 26 patients had c
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148 R. Komaki Around 1998, by using
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150 R. Komaki Table 8-5. Survival a
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152 R. Komaki A total of 610 patien
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154 R. Komaki tially obstructed air
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156 R. Komaki report of Radiation T
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9 TREATMENT OF PATIENTS WITH ADVANC
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160 R. Zinner chemotherapy, in pati
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Table 9-1. Chemotherapy in Older Pa
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164 R. Zinner results of additional
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Table 9-3. Third-Generation-Agent M
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Table 9-4. Third-Generation Agents
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Table 9-5. Third-Generation Platinu
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Table 9-6. Comparisons between Diff
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174 R. Zinner may play an important
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Table 9-8. Third-Generation Cisplat
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178 R. Zinner wards higher survival
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180 R. Zinner KEY PRACTICE POINTS
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182 R. Zinner DeVore RF, Fehrenbach
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184 R. Zinner Perng RP, Chen YM, Mi
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10 TREATMENT OF LIMITED-STAGE SMALL
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188 R. Komaki Age is not a signific
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190 R. Komaki lished between 1979 a
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Table 10-1. Complete Response Rates
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194 R. Komaki twice daily to a tota
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196 R. Komaki Intergroup study 0096
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198 R. Komaki Figure 10-1. Survival
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200 R. Komaki cisplatin with concur
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202 R. Komaki KEY PRACTICE POINTS
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204 R. Komaki tients (Pts) with lim
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206 R. Komaki Wagner H, Kim K, John
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208 G.R. Blumenschein, Jr. recurs a
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210 G.R. Blumenschein, Jr. syndrome
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212 G.R. Blumenschein, Jr. toxicity
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214 G.R. Blumenschein, Jr. the year
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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Page 295 and 296: 282 W.N. Hittelman, J.M. Kurie, and
Page 313 and 314: 300 Index Anterior spinal column re
Page 315 and 316: 302 Index Cardiac murmurs, 104 Card
Page 317 and 318: 304 Index Diagnosis. See also under
Page 319 and 320: 306 Index Growth. See Tumor growth
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Page 325 and 326: 312 Index Pulmonary resection (cont
Page 327 and 328: 314 Index Squamous metaplasia, 263-
Page 329: 316 Index Vitamin A, 262 Vocal cord
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