Lung Cancer.pdf

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Table 9–2. Single-Agent Third-Generation Agents versus Best Supportive Care as First-Line Therapy Median 1-Year 2-Year Symptoms Study and No. of Response Survival Survival Survival P for Quality Improved with Treatment Regimen Patients Rate Time Rate Rate Survival of Life Chemotherapy? Roszkowski (2000) Docetaxel BSC 137 13% 6.0 months 25% 12% .026 Better Yes BSC 70 — 5.7 months 16% 0% Ranson (2000) Paclitaxel BSC 79 16% 6.8 months 20%– 41% .037 Better Yes BSC 78 — 4.8 months 18%–39% Anderson (2000) Gemcitabine BSC 150 19% 5.7 months 25% .84 Better Yes BSC 150 — 5.9 months 22% Perrone (ELVIS) (1998)* Vinorelbine BSC 80 20% 6.2 months 27% Better Yes BSC 81 — 4.8 months 5% .04 Crawford (1996) Vinorelbine 143 12%† 6.9 months 25% .03 5-FU leucovorin 68 3% 5.1 months 16% — BSC indicates best supportive care; 5-FU, fluorouracil; and NR, not reported. * All patients at least 70 years of age. † No P value reported. Treatment of Patients with Advanced Non–Small Cell Lung Cancer 165
Table 9–3. Third-Generation-Agent Monotherapy versus Cisplatin plus the Same Monotherapy or an Older-Generation Agent Study and No. of Response Median 1-Year P for Treatment Regimen Patients Rate Survival Time Survival Rate Survival Le Chevalier (1994, 2001) Phase III Studies Vinorelbine 206 14%* (P .001) 7.2 months 30% .01* Cisplatin vindesine 200 19% (P .02) 7.6 months 27% .04† Cisplatin vinorelbine 206 30% † 9.2 months 35% Depierre (1994) Vinorelbine 119 16% 7.4 months NR Cisplatin vinorelbine 121 43% (P .0001) 7.6 months NR .48 Komiya (2000) Irinotecan 129 21% 10.6 months 42% Cisplatin vindesine 126 32% 10.6 months 38% Cisplatin irinotecan 130 44% (P .0004) 11.5 months 47% .145 Manegold (1997) Phase II Studies Gemcitabine 71 18% 6.6 months Cisplatin etoposide 75 15% 7.6 months Perng (1997) Gemcitabine 27 19% 8.5 months Cisplatin etoposide 26 21% 11.1 months NR indicates not reported. * Cisplatin and vinorelbine versus vinorelbine alone. † Cisplatin and vindesine versus cisplatin and vinorelbine. Adapted from vol 1 no 4 Lung Cancer. 166 R. Zinner
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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66 P. Tamboli and J.Y. Ro Atypical
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68 P. Tamboli and J.Y. Ro Diffuse I
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70 P. Tamboli and J.Y. Ro noma. Cig
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72 P. Tamboli and J.Y. Ro Figure 4-
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74 P. Tamboli and J.Y. Ro alone. BA
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76 P. Tamboli and J.Y. Ro Other Mal
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78 P. Tamboli and J.Y. Ro Electron
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80 P. Tamboli and J.Y. Ro Niho S, Y
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82 Y. De Jesus and G.L. Walsh Chapt
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84 Y. De Jesus and G.L. Walsh Figur
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86 Y. De Jesus and G.L. Walsh guide
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88 Y. De Jesus and G.L. Walsh with
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Figure 5-2. Patient “pathway to r
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94 Y. De Jesus and G.L. Walsh Recov
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98 Y. De Jesus and G.L. Walsh KEY P
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100 Y. De Jesus and G.L. Walsh Jenn
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102 W.R. Smythe nation for these su
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104 W.R. Smythe patient reports of
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106 W.R. Smythe bar or limited lung
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108 W.R. Smythe hospitals for 149 p
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110 W.R. Smythe Figure 6-1. Postsur
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112 W.R. Smythe nant neoplasms has
Page 127 and 128: 114 W.R. Smythe Future Directions F
Page 129 and 130: 116 W.R. Smythe Henschke CI, McCaul
Page 131 and 132: 7 SURGICAL TREATMENT OF LOCALLY ADV
Page 133 and 134: 120 S.G. Swisher Treatment Options
Page 135 and 136: 122 S.G. Swisher Initial Assessment
Page 137 and 138: 124 S.G. Swisher Figure 7-1. Region
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Page 141 and 142: 128 S.G. Swisher upper paratracheal
Page 143 and 144: 130 S.G. Swisher is performed only
Page 145 and 146: 132 S.G. Swisher chance for long-te
Page 147 and 148: 134 S.G. Swisher Pancoast tumors th
Page 149 and 150: 136 S.G. Swisher A B Figure 7-2. Do
Page 151 and 152: 138 S.G. Swisher a combination of t
Page 153 and 154: 140 S.G. Swisher Dartevelle PG, Cha
Page 155 and 156: 8 NONSURGICAL TREATMENT OF EARLY-ST
Page 157 and 158: 144 R. Komaki morbid conditions pre
Page 159 and 160: 146 R. Komaki and 26 patients had c
Page 161 and 162: 148 R. Komaki Around 1998, by using
Page 163 and 164: 150 R. Komaki Table 8-5. Survival a
Page 165 and 166: 152 R. Komaki A total of 610 patien
Page 167 and 168: 154 R. Komaki tially obstructed air
Page 169 and 170: 156 R. Komaki report of Radiation T
Page 171 and 172: 9 TREATMENT OF PATIENTS WITH ADVANC
Page 173 and 174: 160 R. Zinner chemotherapy, in pati
Page 175 and 176: Table 9-1. Chemotherapy in Older Pa
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Page 181 and 182: Table 9-4. Third-Generation Agents
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Page 185 and 186: Table 9-6. Comparisons between Diff
Page 187 and 188: 174 R. Zinner may play an important
Page 189 and 190: Table 9-8. Third-Generation Cisplat
Page 191 and 192: 178 R. Zinner wards higher survival
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Page 201 and 202: 188 R. Komaki Age is not a signific
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Page 205 and 206: Table 10-1. Complete Response Rates
Page 207 and 208: 194 R. Komaki twice daily to a tota
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Page 211 and 212: 198 R. Komaki Figure 10-1. Survival
Page 213 and 214: 200 R. Komaki cisplatin with concur
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Page 219 and 220: 206 R. Komaki Wagner H, Kim K, John
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Page 223 and 224: 210 G.R. Blumenschein, Jr. syndrome
Page 225 and 226: 212 G.R. Blumenschein, Jr. toxicity
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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258 E.S. Kim and F.R. Khuri A secon
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260 E.S. Kim and F.R. Khuri Smoking
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262 E.S. Kim and F.R. Khuri Reversa
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264 E.S. Kim and F.R. Khuri yet to
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266 E.S. Kim and F.R. Khuri nation
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268 E.S. Kim and F.R. Khuri Methodo
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270 E.S. Kim and F.R. Khuri have be
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272 E.S. Kim and F.R. Khuri the tre
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274 E.S. Kim and F.R. Khuri changes
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276 E.S. Kim and F.R. Khuri KEY PRA
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278 E.S. Kim and F.R. Khuri Hong WK
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15 MOLECULAR EVENTS IN LUNG CANCER
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282 W.N. Hittelman, J.M. Kurie, and
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300 Index Anterior spinal column re
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302 Index Cardiac murmurs, 104 Card
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304 Index Diagnosis. See also under
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306 Index Growth. See Tumor growth
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308 Index Magnetic resonance (MR) i
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310 Index p16 gene, 285 p19 arf gen
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312 Index Pulmonary resection (cont
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314 Index Squamous metaplasia, 263-
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316 Index Vitamin A, 262 Vocal cord
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