Lung Cancer.pdf

Recommendations

Info

Chemotherapy for Extensive-Stage Small Cell Lung Cancer 219 Roth BJ, Johnson DH, Einhorn LH, et al. Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group. J Clin Oncol 1992;10:282–291. Sandler AB. Current management of small cell lung cancer. Semin Oncol 1997;24:463– 476. Schiller JH, Adak S, Cella D, et al. Topotecan versus observation after cisplatin plus etoposide in extensive-stage small-cell lung cancer: E7593—a phase III trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2001;19:2114–2122. Souhami RL, Spiro SG, Rudd RM, et al. Five-day oral etoposide treatment for advanced small-cell lung cancer: randomized comparison with intravenous chemotherapy. J Natl Cancer Inst 1997;89:577–580. von Pawel J, Schiller JH, Shepherd FA, et al. Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. J Clin Oncol 1999;17:658–667.
12 PALLIATIVE CARE IN PATIENTS WITH LUNG CANCER Joe B. Putnam, Jr. Chapter Overview ....................................................................................... 220 Introduction ................................................................................................. 221 Patient Evaluation ....................................................................................... 221 Symptoms and Palliative Treatment Approaches .................................. 223 Constitutional Symptoms ..................................................................... 223 Symptoms Due to Brain Metastases ................................................... 224 Depression .............................................................................................. 224 Pain .......................................................................................................... 224 Symptoms of Advanced-Stage Lung Cancer ..................................... 225 Symptoms of Superior Sulcus Tumors .......................................... 225 Lung-Sparing Surgery to Prevent Dyspnea .................................. 227 Pulmonary or Respiratory Insufficiency ............................................ 227 Dyspnea ............................................................................................. 228 Malignant Pleural Effusions ........................................................... 228 Etiology ......................................................................................... 228 Prognosis ...................................................................................... 229 Therapy ......................................................................................... 229 Sclerotherapy .......................................................................... 229 Chronic Indwelling Pleural Catheter .................................. 230 Outpatient Management of Malignant Pleural Effusions ... 233 Extrinsic Compression of Airway .................................................. 235 Intraluminal Tumor .......................................................................... 236 Alimentation and Nutrition ...................................................................... 237 Key Practice Points ..................................................................................... 238 Suggested Readings .................................................................................... 238 Chapter Overview Palliation of symptoms may be required at any point in a lung cancer patient’s care. Moving from “therapy-oriented care” to “comfort-oriented care” poses special challenges to the physician and the health care team: they must attempt to optimize the function of each individual patient and to communicate the care plan to the patient’s family and friends. Relief of
Page 1 and 2:
Lung Cancer Frank V. Fossella, MD R
Page 3 and 4:
This page intentionally left blank
Page 5 and 6:
Frank V. Fossella, MD Department of
Page 7 and 8:
vi Foreword possible. Since the res
Page 9 and 10:
This page intentionally left blank
Page 11 and 12:
x Contents Chapter 7 Surgical Treat
Page 13 and 14:
xii Contributors Joe B. Putnam, Jr.
Page 15 and 16:
2 J.B. Putnam, Jr., F.V. Fossella,
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
26 F.V. Fossella common sites of lu
Page 41 and 42:
28 F.V. Fossella history and physic
Page 43 and 44:
30 F.V. Fossella Computed Tomograph
Page 45 and 46:
32 F.V. Fossella Pulmonary Function
Page 47 and 48:
34 F.V. Fossella The use of flexibl
Page 49 and 50:
36 R.F. Munden and J.J. Erasmus hav
Page 51 and 52:
38 R.F. Munden and J.J. Erasmus che
Page 53 and 54:
40 R.F. Munden and J.J. Erasmus tha
Page 55 and 56:
42 R.F. Munden and J.J. Erasmus (Gu
Page 57 and 58:
44 R.F. Munden and J.J. Erasmus A B
Page 59 and 60:
46 R.F. Munden and J.J. Erasmus in
Page 61 and 62:
48 R.F. Munden and J.J. Erasmus Pat
Page 63 and 64:
50 R.F. Munden and J.J. Erasmus D C
Page 65 and 66:
52 R.F. Munden and J.J. Erasmus A B
Page 67 and 68:
54 R.F. Munden and J.J. Erasmus Bol
Page 69 and 70:
56 R.F. Munden and J.J. Erasmus Swe
Page 71 and 72:
58 P. Tamboli and J.Y. Ro Chapter O
Page 73 and 74:
60 P. Tamboli and J.Y. Ro Figure 4-
Page 75 and 76:
62 P. Tamboli and J.Y. Ro Postopera
Page 77 and 78:
64 P. Tamboli and J.Y. Ro Table 4-1
Page 79 and 80:
66 P. Tamboli and J.Y. Ro Atypical
Page 81 and 82:
68 P. Tamboli and J.Y. Ro Diffuse I
Page 83 and 84:
70 P. Tamboli and J.Y. Ro noma. Cig
Page 85 and 86:
72 P. Tamboli and J.Y. Ro Figure 4-
Page 87 and 88:
74 P. Tamboli and J.Y. Ro alone. BA
Page 89 and 90:
76 P. Tamboli and J.Y. Ro Other Mal
Page 91 and 92:
78 P. Tamboli and J.Y. Ro Electron
Page 93 and 94:
80 P. Tamboli and J.Y. Ro Niho S, Y
Page 95 and 96:
82 Y. De Jesus and G.L. Walsh Chapt
Page 97 and 98:
84 Y. De Jesus and G.L. Walsh Figur
Page 99 and 100:
86 Y. De Jesus and G.L. Walsh guide
Page 101 and 102:
88 Y. De Jesus and G.L. Walsh with
Page 103 and 104:
Figure 5-2. Patient “pathway to r
Page 105 and 106:
Page 107 and 108:
94 Y. De Jesus and G.L. Walsh Recov
Page 109 and 110:
Page 111 and 112:
98 Y. De Jesus and G.L. Walsh KEY P
Page 113 and 114:
100 Y. De Jesus and G.L. Walsh Jenn
Page 115 and 116:
102 W.R. Smythe nation for these su
Page 117 and 118:
104 W.R. Smythe patient reports of
Page 119 and 120:
106 W.R. Smythe bar or limited lung
Page 121 and 122:
108 W.R. Smythe hospitals for 149 p
Page 123 and 124:
110 W.R. Smythe Figure 6-1. Postsur
Page 125 and 126:
112 W.R. Smythe nant neoplasms has
Page 127 and 128:
114 W.R. Smythe Future Directions F
Page 129 and 130:
116 W.R. Smythe Henschke CI, McCaul
Page 131 and 132:
7 SURGICAL TREATMENT OF LOCALLY ADV
Page 133 and 134:
120 S.G. Swisher Treatment Options
Page 135 and 136:
122 S.G. Swisher Initial Assessment
Page 137 and 138:
124 S.G. Swisher Figure 7-1. Region
Page 139 and 140:
126 S.G. Swisher Table 7-2. (contin
Page 141 and 142:
128 S.G. Swisher upper paratracheal
Page 143 and 144:
130 S.G. Swisher is performed only
Page 145 and 146:
132 S.G. Swisher chance for long-te
Page 147 and 148:
134 S.G. Swisher Pancoast tumors th
Page 149 and 150:
136 S.G. Swisher A B Figure 7-2. Do
Page 151 and 152:
138 S.G. Swisher a combination of t
Page 153 and 154:
140 S.G. Swisher Dartevelle PG, Cha
Page 155 and 156:
8 NONSURGICAL TREATMENT OF EARLY-ST
Page 157 and 158:
144 R. Komaki morbid conditions pre
Page 159 and 160:
146 R. Komaki and 26 patients had c
Page 161 and 162:
148 R. Komaki Around 1998, by using
Page 163 and 164:
150 R. Komaki Table 8-5. Survival a
Page 165 and 166:
152 R. Komaki A total of 610 patien
Page 167 and 168:
154 R. Komaki tially obstructed air
Page 169 and 170:
156 R. Komaki report of Radiation T
Page 171 and 172:
9 TREATMENT OF PATIENTS WITH ADVANC
Page 173 and 174:
160 R. Zinner chemotherapy, in pati
Page 175 and 176:
Table 9-1. Chemotherapy in Older Pa
Page 177 and 178:
164 R. Zinner results of additional
Page 179 and 180:
Table 9-3. Third-Generation-Agent M
Page 181 and 182: Table 9-4. Third-Generation Agents
Page 183 and 184: Table 9-5. Third-Generation Platinu
Page 185 and 186: Table 9-6. Comparisons between Diff
Page 187 and 188: 174 R. Zinner may play an important
Page 189 and 190: Table 9-8. Third-Generation Cisplat
Page 191 and 192: 178 R. Zinner wards higher survival
Page 193 and 194: 180 R. Zinner KEY PRACTICE POINTS
Page 195 and 196: 182 R. Zinner DeVore RF, Fehrenbach
Page 197 and 198: 184 R. Zinner Perng RP, Chen YM, Mi
Page 199 and 200: 10 TREATMENT OF LIMITED-STAGE SMALL
Page 201 and 202: 188 R. Komaki Age is not a signific
Page 203 and 204: 190 R. Komaki lished between 1979 a
Page 205 and 206: Table 10-1. Complete Response Rates
Page 207 and 208: 194 R. Komaki twice daily to a tota
Page 209 and 210: 196 R. Komaki Intergroup study 0096
Page 211 and 212: 198 R. Komaki Figure 10-1. Survival
Page 213 and 214: 200 R. Komaki cisplatin with concur
Page 215 and 216: 202 R. Komaki KEY PRACTICE POINTS
Page 217 and 218: 204 R. Komaki tients (Pts) with lim
Page 219 and 220: 206 R. Komaki Wagner H, Kim K, John
Page 221 and 222: 208 G.R. Blumenschein, Jr. recurs a
Page 223 and 224: 210 G.R. Blumenschein, Jr. syndrome
Page 225 and 226: 212 G.R. Blumenschein, Jr. toxicity
Page 227 and 228: 214 G.R. Blumenschein, Jr. the year
Page 229 and 230: 216 G.R. Blumenschein, Jr. is chara
Page 231: 218 G.R. Blumenschein, Jr. new cyto
Page 235 and 236: 222 J.B. Putnam, Jr. therapy. Patie
Page 237 and 238: 224 J.B. Putnam, Jr. tion—includi
Page 239 and 240: 226 J.B. Putnam, Jr. rates were 47%
Page 241 and 242: 228 J.B. Putnam, Jr. Dyspnea The ma
Page 243 and 244: 230 J.B. Putnam, Jr. Small-bore cat
Page 245 and 246: 232 J.B. Putnam, Jr. A B Figure 12-
Page 247 and 248: 234 J.B. Putnam, Jr. C D Figure 12-
Page 249 and 250: 236 J.B. Putnam, Jr. B Figure 12-3.
Page 251 and 252: 238 J.B. Putnam, Jr. KEY PRACTICE P
Page 253 and 254: 240 J.B. Putnam, Jr. Rendina EA, De
Page 255 and 256: 242 A.A. Vaporciyan, J.F. Kelly, an
Page 269 and 270: 14 PREVENTION AND EARLY DETECTION O
Page 271 and 272: 258 E.S. Kim and F.R. Khuri A secon
Page 273 and 274: 260 E.S. Kim and F.R. Khuri Smoking
Page 275 and 276: 262 E.S. Kim and F.R. Khuri Reversa
Page 277 and 278: 264 E.S. Kim and F.R. Khuri yet to
Page 279 and 280: 266 E.S. Kim and F.R. Khuri nation
Page 281 and 282: 268 E.S. Kim and F.R. Khuri Methodo
Page 283 and 284:
270 E.S. Kim and F.R. Khuri have be
Page 285 and 286:
272 E.S. Kim and F.R. Khuri the tre
Page 287 and 288:
274 E.S. Kim and F.R. Khuri changes
Page 289 and 290:
276 E.S. Kim and F.R. Khuri KEY PRA
Page 291 and 292:
278 E.S. Kim and F.R. Khuri Hong WK
Page 293 and 294:
15 MOLECULAR EVENTS IN LUNG CANCER
Page 295 and 296:
282 W.N. Hittelman, J.M. Kurie, and
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
300 Index Anterior spinal column re
Page 315 and 316:
302 Index Cardiac murmurs, 104 Card
Page 317 and 318:
304 Index Diagnosis. See also under
Page 319 and 320:
306 Index Growth. See Tumor growth
Page 321 and 322:
308 Index Magnetic resonance (MR) i
Page 323 and 324:
310 Index p16 gene, 285 p19 arf gen
Page 325 and 326:
312 Index Pulmonary resection (cont
Page 327 and 328:
314 Index Squamous metaplasia, 263-
Page 329:
316 Index Vitamin A, 262 Vocal cord
show all

Lung Cancer.pdf

Create successful ePaper yourself

Delete template?

Save as template?