Lung Cancer.pdf

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Index 313 Refractory SCLC, 215-217 Renal toxicity, 167, 253 Resections. See Surgical resection Respiratory findings, 104 Respiratory insufficiency, 227 Response to treatment, 51-53 Retinoblastoma (RB) gene, 15, 78, 285 13-cis Retinoic acid (13-cRA), 262 Retinoic acid receptor- (RAR-), 270-271 Retinoic X receptor-, 270 Retinoids, 262 Retinyl palmitate, 263-264, 268, 269 Retrotracheal lymph nodes, 124, 125 Rhabdomyosarcoma, 75 RhoB, 293 Risk estimation, 288-289 S66336, 293 Salivary-gland-type carcinomas, 64, 76 Sarcomatoid carcinomas, 75, 78 Scarring, 51 SCH66336, 273 Sclerotherapy, 229-230 Screening cardiovascular, 122 difficulties, 3, 7 interest in, 37-38 lung cancer, 275-277 molecular changes, 290 pretreatment PET, 112 smoking history, 112-113 survival rates and, 35-36 Segmental lymph nodes, 124, 126 Seizures, 224 Selenium, 264-265, 270 Senna, 246 Seromas, 254 Serum chemistry, 29 SF-36 (Medical Outcomes Study Short Form Survey), 222 Signaling pathways, 292-294 Signs and symptoms of lung cancer, 26-27, 209-210 Skin reactions, 245 Small cell lung cancer (SCLC). See entries for specific types Smoking assessment of, 223 cessation, 260, 282 exposure to, 6, 282 lung cancer and, 257-258, 259 neuroendocrine tumors and, 70 prevention interventions, 260 respiratory insufficiency, 227 SCLC outcomes and, 188 SCLC risk and, 208 screening based on, 112-113 Social habits, assessment, 223 Sodium levels, 188, 209. See also Electrolyte abnormalities Sonography, transesophageal, 14 Southwest Oncology Group, 191 Spinal column reconstruction, 226 Spinal cord compression, 28 invasion of, 137-138 metastases, 199 myelitis, 17 suggested maximum radiation doses, 249 surgical resection, 19 Spinal fixation, 137-138 Spinal instrumentation, 226 Spirometry, 87, 105, 122 Sputum, 7, 14, 32 Squamous cell carcinomas frequency, 69 NSCLC classification as, 60 outcomes, 227 p53 mutations, 78 pathology, 69 TTF-1 staining, 76-77 WHO classification, 63 Squamous dysplasia, 62, 63, 64-65, 78
314 Index Squamous metaplasia, 263-264 Staffing models, 94 Staging downstaging by chemotherapy, 136 groupings for, 11 measurement bias, 111-113 nonsurgical treatment and, 143-152 NSCLC, 17-19, 36, 43-48, 123-130 pretreatment evaluation, 8-15 regional lymph node stations, 124 SCLC, 48-51, 208-209 therapeutic choices and, 8 Staples, 251, 252 Stents, 235-236, 237 Stridor, 7, 27 Subaortic lymph nodes, 124, 125 Subcarinal lymph nodes, 124, 125 Subclavian arteries, 137 Submucosal tumors, 33 Subsegmental lymph nodes, 124, 126 Sucralfate (Carofate) slurries, 245 Superior sulcus tumors, 86-87, 152-153, 225-227 Superior vena cava syndrome, 7, 27, 209 Superior vena cavae, 6 Surfactant apoprotein A, 76 Surgeon General, 259 Surgeons, team work, 3, 16 Surgery. See also Surgical resection brain metastases, 19, 224 fitness for, 143 future trends, 97-99 NSCLC, 17-18, 19-20, 105-107, 118-141 radiation therapy versus, 107-108 SCLC, 88-89 Surgical resection. See also Surgery assessment of patients after, 36 brain metastases, 19, 224 bronchial sleeve, 227 bronchoscopy prior to, 13 chest wall, 128 chest wall, en bloc, 226 clinical pathways, 89-97 limited versus full, 106-107 pulmonary artery sleeve resection, 227 spinal cord, 19 strategy, 128-129 thoracoscopic, 106 tracheal, 227 Survival rates improvement, 3 NSCLC, 8 palliative care and, 221 SCLC, 209 screening and, 35-36 surgical improvement, 19 Swallowing, 246 Swelling, 26 Synaptophysin, 71, 72, 77 Syndrome of inappropriate secretion of antidiuretic hormone (SIADH), 29, 209 Talc sclerotherapy, 229 Tarceva (OSI-774), 179 Targeted receptor therapy, 21 Targretin (LGD1069), 293 TAX 317 study, 177 TAX 320 study, 177 TAX 326 study, 167, 169, 173 Taxanes, 210 Taxotere. See Docetaxel Telemetry units, 93 Telomerase activity, 66 Telomerase genes, 287 Teniposide, 210
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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66 P. Tamboli and J.Y. Ro Atypical
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68 P. Tamboli and J.Y. Ro Diffuse I
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70 P. Tamboli and J.Y. Ro noma. Cig
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72 P. Tamboli and J.Y. Ro Figure 4-
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74 P. Tamboli and J.Y. Ro alone. BA
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76 P. Tamboli and J.Y. Ro Other Mal
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78 P. Tamboli and J.Y. Ro Electron
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80 P. Tamboli and J.Y. Ro Niho S, Y
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82 Y. De Jesus and G.L. Walsh Chapt
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84 Y. De Jesus and G.L. Walsh Figur
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86 Y. De Jesus and G.L. Walsh guide
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88 Y. De Jesus and G.L. Walsh with
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Figure 5-2. Patient “pathway to r
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94 Y. De Jesus and G.L. Walsh Recov
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98 Y. De Jesus and G.L. Walsh KEY P
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100 Y. De Jesus and G.L. Walsh Jenn
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102 W.R. Smythe nation for these su
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104 W.R. Smythe patient reports of
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106 W.R. Smythe bar or limited lung
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108 W.R. Smythe hospitals for 149 p
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110 W.R. Smythe Figure 6-1. Postsur
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112 W.R. Smythe nant neoplasms has
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114 W.R. Smythe Future Directions F
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116 W.R. Smythe Henschke CI, McCaul
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7 SURGICAL TREATMENT OF LOCALLY ADV
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120 S.G. Swisher Treatment Options
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122 S.G. Swisher Initial Assessment
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124 S.G. Swisher Figure 7-1. Region
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126 S.G. Swisher Table 7-2. (contin
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128 S.G. Swisher upper paratracheal
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130 S.G. Swisher is performed only
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132 S.G. Swisher chance for long-te
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134 S.G. Swisher Pancoast tumors th
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136 S.G. Swisher A B Figure 7-2. Do
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138 S.G. Swisher a combination of t
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140 S.G. Swisher Dartevelle PG, Cha
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8 NONSURGICAL TREATMENT OF EARLY-ST
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144 R. Komaki morbid conditions pre
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146 R. Komaki and 26 patients had c
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148 R. Komaki Around 1998, by using
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150 R. Komaki Table 8-5. Survival a
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152 R. Komaki A total of 610 patien
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154 R. Komaki tially obstructed air
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156 R. Komaki report of Radiation T
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9 TREATMENT OF PATIENTS WITH ADVANC
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160 R. Zinner chemotherapy, in pati
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Table 9-1. Chemotherapy in Older Pa
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164 R. Zinner results of additional
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Table 9-3. Third-Generation-Agent M
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Table 9-4. Third-Generation Agents
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Table 9-5. Third-Generation Platinu
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Table 9-6. Comparisons between Diff
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174 R. Zinner may play an important
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Table 9-8. Third-Generation Cisplat
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178 R. Zinner wards higher survival
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180 R. Zinner KEY PRACTICE POINTS
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182 R. Zinner DeVore RF, Fehrenbach
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184 R. Zinner Perng RP, Chen YM, Mi
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10 TREATMENT OF LIMITED-STAGE SMALL
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188 R. Komaki Age is not a signific
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190 R. Komaki lished between 1979 a
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Table 10-1. Complete Response Rates
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194 R. Komaki twice daily to a tota
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196 R. Komaki Intergroup study 0096
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198 R. Komaki Figure 10-1. Survival
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200 R. Komaki cisplatin with concur
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202 R. Komaki KEY PRACTICE POINTS
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204 R. Komaki tients (Pts) with lim
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206 R. Komaki Wagner H, Kim K, John
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208 G.R. Blumenschein, Jr. recurs a
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210 G.R. Blumenschein, Jr. syndrome
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212 G.R. Blumenschein, Jr. toxicity
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214 G.R. Blumenschein, Jr. the year
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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258 E.S. Kim and F.R. Khuri A secon
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260 E.S. Kim and F.R. Khuri Smoking
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Page 295 and 296: 282 W.N. Hittelman, J.M. Kurie, and
Page 313 and 314: 300 Index Anterior spinal column re
Page 315 and 316: 302 Index Cardiac murmurs, 104 Card
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Page 319 and 320: 306 Index Growth. See Tumor growth
Page 321 and 322: 308 Index Magnetic resonance (MR) i
Page 323 and 324: 310 Index p16 gene, 285 p19 arf gen
Page 325: 312 Index Pulmonary resection (cont
Page 329: 316 Index Vitamin A, 262 Vocal cord
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