Lung Cancer.pdf

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Index 315 Thalidomide, 296 Thoracentesis, 32, 188, 229 Thoracic radiation therapy (TRT) CNS metastases and, 200 dose to thorax, 197-198 fractionation, 195-197 at M. D. Anderson, 200-201 SCLC, 187, 189-201 volume irradiated, 195 Thoracic surgery, sequalae, 248-254 Thoracoscopy, video-assisted, 13 Thoracotomy emergency, 237 posterior-lateral, 226 Thoracotomy trays, 93 Thromboxanes, 265 Thrush, 245 Thyroid gland, 76-77 Thyroid transcription factor 1 (TTF-1), 76-77 Tirapazamine, 167, 168 TisSeel, 252 Tissue margins, 61 Tissue sealants, 252 T4N0–1 tumors, 135-138 T3N1 tumors, 123, 126-130 TNP-470, 296 Tobacco. See Smoking -Tocopherol, 264, 268 Topoisomerase I inhibitors, 210 Topotecan, 210, 216 Tracheal resection, 227 Transbronchial biopsies, 13, 33, 60 Transesophageal sonography, 14 Transforming growth factor alpha, 287 Transfusions, 250 Transthoracic needle aspiration (TTNA) biopsy, 13-14, 34, 42-43 “Trapped” lung, 230 Trastuzumab (Herceptin), 178 Tube thoracostomy, 229 Tumor burden, 223 Tumor growth, diagnosis and, 38-40, 59 Tumor suppressor genes, 284-286. See also entries for specific genes Tumor volume, 40 Unclassified carcinomas, 64, 76 Union Internationale Contre le Cancer, 8 Upper airway obstruction, 27 Upper paratracheal lymph nodes, 124, 125 Vascular endothelial growth factor (VEGF), 178-179, 179, 287 Vascular endothelial growth factor receptor (VEGFR), 296 Venous distension, 26-27 Vertebral bodies, 31 Vertebral invasion, 226 Vertebrectomy, 226 Veterans Administration Lung Cancer Study Group trial, 48, 210 Video-assisted thoracic surgery (VATS), 229 Video-assisted thoracoscopy, 13 Vinblastine, 148, 150, 151-152, 163 Vinca alkaloids, 210. See also entries for specific agents Vincristine, 191, 194, 195, 210 Vindesine, 21, 166, 170 Vinorelbine best supportive care and, 162, 165 cisplatin and, 166, 167, 168 ifosfamide and, 177-178 MVP therapy and, 163 NSCLC, 161 platinum-based agents with, 170 quality of life and, 164 SCLC, 210
316 Index Vitamin A, 262 Vocal cord paralysis, 27 Vocal cords, 93 Weakness, 29 Weight loss. See also Anorexia; Appetite; Cachexia at diagnosis, 7 palliative care and, 222 paraneoplastic disorders and, 28 during radiation therapy, 246 SCLC, 209 Wheezing, 7 White blood cell count, 250 World Health Organization (WHO) classification, 62, 63-64, 65 Wound care, 91, 111, 254 Wound dehiscence, 246 WR21–27 (ethyol), 21 Xenon ventilation perfusion lung scanning, 32, 228 ZD1839 (Iressa), 179, 274-275, 296 Zubrod performance status, 222, 233-234, 247
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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66 P. Tamboli and J.Y. Ro Atypical
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68 P. Tamboli and J.Y. Ro Diffuse I
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70 P. Tamboli and J.Y. Ro noma. Cig
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72 P. Tamboli and J.Y. Ro Figure 4-
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74 P. Tamboli and J.Y. Ro alone. BA
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76 P. Tamboli and J.Y. Ro Other Mal
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78 P. Tamboli and J.Y. Ro Electron
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80 P. Tamboli and J.Y. Ro Niho S, Y
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82 Y. De Jesus and G.L. Walsh Chapt
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84 Y. De Jesus and G.L. Walsh Figur
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86 Y. De Jesus and G.L. Walsh guide
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88 Y. De Jesus and G.L. Walsh with
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Figure 5-2. Patient “pathway to r
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94 Y. De Jesus and G.L. Walsh Recov
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98 Y. De Jesus and G.L. Walsh KEY P
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100 Y. De Jesus and G.L. Walsh Jenn
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102 W.R. Smythe nation for these su
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104 W.R. Smythe patient reports of
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106 W.R. Smythe bar or limited lung
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108 W.R. Smythe hospitals for 149 p
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110 W.R. Smythe Figure 6-1. Postsur
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112 W.R. Smythe nant neoplasms has
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114 W.R. Smythe Future Directions F
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116 W.R. Smythe Henschke CI, McCaul
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7 SURGICAL TREATMENT OF LOCALLY ADV
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120 S.G. Swisher Treatment Options
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122 S.G. Swisher Initial Assessment
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124 S.G. Swisher Figure 7-1. Region
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126 S.G. Swisher Table 7-2. (contin
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128 S.G. Swisher upper paratracheal
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130 S.G. Swisher is performed only
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132 S.G. Swisher chance for long-te
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134 S.G. Swisher Pancoast tumors th
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136 S.G. Swisher A B Figure 7-2. Do
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138 S.G. Swisher a combination of t
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140 S.G. Swisher Dartevelle PG, Cha
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8 NONSURGICAL TREATMENT OF EARLY-ST
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144 R. Komaki morbid conditions pre
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146 R. Komaki and 26 patients had c
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148 R. Komaki Around 1998, by using
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150 R. Komaki Table 8-5. Survival a
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152 R. Komaki A total of 610 patien
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154 R. Komaki tially obstructed air
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156 R. Komaki report of Radiation T
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9 TREATMENT OF PATIENTS WITH ADVANC
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160 R. Zinner chemotherapy, in pati
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Table 9-1. Chemotherapy in Older Pa
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164 R. Zinner results of additional
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Table 9-3. Third-Generation-Agent M
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Table 9-4. Third-Generation Agents
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Table 9-5. Third-Generation Platinu
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Table 9-6. Comparisons between Diff
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174 R. Zinner may play an important
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Table 9-8. Third-Generation Cisplat
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178 R. Zinner wards higher survival
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180 R. Zinner KEY PRACTICE POINTS
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182 R. Zinner DeVore RF, Fehrenbach
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184 R. Zinner Perng RP, Chen YM, Mi
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10 TREATMENT OF LIMITED-STAGE SMALL
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188 R. Komaki Age is not a signific
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190 R. Komaki lished between 1979 a
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Table 10-1. Complete Response Rates
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194 R. Komaki twice daily to a tota
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196 R. Komaki Intergroup study 0096
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198 R. Komaki Figure 10-1. Survival
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200 R. Komaki cisplatin with concur
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202 R. Komaki KEY PRACTICE POINTS
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204 R. Komaki tients (Pts) with lim
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206 R. Komaki Wagner H, Kim K, John
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208 G.R. Blumenschein, Jr. recurs a
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210 G.R. Blumenschein, Jr. syndrome
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212 G.R. Blumenschein, Jr. toxicity
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214 G.R. Blumenschein, Jr. the year
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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258 E.S. Kim and F.R. Khuri A secon
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260 E.S. Kim and F.R. Khuri Smoking
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262 E.S. Kim and F.R. Khuri Reversa
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Page 295 and 296: 282 W.N. Hittelman, J.M. Kurie, and
Page 313 and 314: 300 Index Anterior spinal column re
Page 315 and 316: 302 Index Cardiac murmurs, 104 Card
Page 317 and 318: 304 Index Diagnosis. See also under
Page 319 and 320: 306 Index Growth. See Tumor growth
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Page 323 and 324: 310 Index p16 gene, 285 p19 arf gen
Page 325 and 326: 312 Index Pulmonary resection (cont
Page 327: 314 Index Squamous metaplasia, 263-
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