Lung Cancer.pdf

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Pathologic Evaluation of Lung Cancer 63 Table 4–1. World Health Organization Classification of Epithelial Tumors of the Lung Benign Tumors Papilloma Squamous cell papilloma Exophytic Inverted Glandular papilloma Mixed squamous cell and glandular papilloma Adenoma Alveolar adenoma Papillary adenoma Adenoma of salivary-gland type Mucous gland adenoma Pleomorphic adenoma Mucinous cystadenoma Preinvasive Lesions Squamous dysplasia and carcinoma in situ Atypical adenomatous hyperplasia Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia Malignant Tumors Squamous cell carcinoma Papillary squamous cell carcinoma Clear cell squamous cell carcinoma Small cell squamous cell carcinoma Basaloid squamous cell carcinoma Small cell carcinoma Small cell carcinoma Combined small cell carcinoma Adenocarcinoma Acinar adenocarcinoma Papillary adenocarcinoma Bronchioloalveolar adenocarcinoma Nonmucinous Mucinous Mixed mucinous and nonmucinous or indeterminate cell type Solid adenocarcinoma with mucin Adenocarcinoma with mixed subtypes Well-differentiated fetal adenocarcinoma Mucinous (colloid) adenocarcinoma Mucinous cystadenocarcinoma Signet-ring adenocarcinoma Clear cell adenocarcinoma (continued)
64 P. Tamboli and J.Y. Ro Table 4–1. (continued) World Health Organization Classification of Epithelial Tumors of the Lung Malignant Tumors (continued) Large cell carcinoma Large cell neuroendocrine carcinoma Combined large cell neuroendocrine carcinoma Basaloid carcinoma Lymphoepithelioma-like carcinoma Clear cell carcinoma Large cell carcinoma with rhabdoid phenotype Adenosquamous carcinoma Carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements Carcinoma with spindle and/or giant cells Pleomorphic carcinoma Spindle cell carcinoma Giant cell carcinoma Carcinosarcoma Pulmonary blastoma Carcinoid tumor Typical carcinoid Atypical carcinoid Carcinoma of salivary-gland type Mucoepidermoid carcinoma Adenoid cystic carcinoma Acinic cell carcinoma Epimyoepithelial carcinoma Malignant mixed tumor Unclassified carcinoma Source: Travis et al, 1999. Squamous Dysplasia and Carcinoma in Situ Squamous mucosa is not a normal component of the tracheobronchial tree but rather develops as a metaplastic response to certain stimuli, most notably cigarette smoke. The presence of squamous metaplasia in the bronchial epithelium does not necessarily mean that squamous dysplasia and carcinoma in situ will follow. Rather, squamous metaplasia is part of the normal physiologic response to injurious stimuli affecting the bronchial mucosa. Squamous dysplasia is the development of abnormalities in the squamous mucosa, including an increase in the number of cell layers, an increase in cell size, variation in cell size, an increased nucleus-to-cytoplasm
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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Page 25 and 26: 12 J.B. Putnam, Jr., F.V. Fossella,
Page 39 and 40: 26 F.V. Fossella common sites of lu
Page 41 and 42: 28 F.V. Fossella history and physic
Page 43 and 44: 30 F.V. Fossella Computed Tomograph
Page 45 and 46: 32 F.V. Fossella Pulmonary Function
Page 47 and 48: 34 F.V. Fossella The use of flexibl
Page 49 and 50: 36 R.F. Munden and J.J. Erasmus hav
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Page 57 and 58: 44 R.F. Munden and J.J. Erasmus A B
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Page 61 and 62: 48 R.F. Munden and J.J. Erasmus Pat
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Page 65 and 66: 52 R.F. Munden and J.J. Erasmus A B
Page 67 and 68: 54 R.F. Munden and J.J. Erasmus Bol
Page 69 and 70: 56 R.F. Munden and J.J. Erasmus Swe
Page 71 and 72: 58 P. Tamboli and J.Y. Ro Chapter O
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Page 115 and 116: 102 W.R. Smythe nation for these su
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Page 119 and 120: 106 W.R. Smythe bar or limited lung
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114 W.R. Smythe Future Directions F
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116 W.R. Smythe Henschke CI, McCaul
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7 SURGICAL TREATMENT OF LOCALLY ADV
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120 S.G. Swisher Treatment Options
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122 S.G. Swisher Initial Assessment
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124 S.G. Swisher Figure 7-1. Region
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126 S.G. Swisher Table 7-2. (contin
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128 S.G. Swisher upper paratracheal
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130 S.G. Swisher is performed only
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132 S.G. Swisher chance for long-te
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134 S.G. Swisher Pancoast tumors th
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136 S.G. Swisher A B Figure 7-2. Do
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138 S.G. Swisher a combination of t
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140 S.G. Swisher Dartevelle PG, Cha
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8 NONSURGICAL TREATMENT OF EARLY-ST
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144 R. Komaki morbid conditions pre
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146 R. Komaki and 26 patients had c
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148 R. Komaki Around 1998, by using
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150 R. Komaki Table 8-5. Survival a
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152 R. Komaki A total of 610 patien
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154 R. Komaki tially obstructed air
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156 R. Komaki report of Radiation T
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9 TREATMENT OF PATIENTS WITH ADVANC
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160 R. Zinner chemotherapy, in pati
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Table 9-1. Chemotherapy in Older Pa
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164 R. Zinner results of additional
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Table 9-3. Third-Generation-Agent M
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Table 9-4. Third-Generation Agents
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Table 9-5. Third-Generation Platinu
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Table 9-6. Comparisons between Diff
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174 R. Zinner may play an important
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Table 9-8. Third-Generation Cisplat
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178 R. Zinner wards higher survival
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180 R. Zinner KEY PRACTICE POINTS
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182 R. Zinner DeVore RF, Fehrenbach
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184 R. Zinner Perng RP, Chen YM, Mi
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10 TREATMENT OF LIMITED-STAGE SMALL
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188 R. Komaki Age is not a signific
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190 R. Komaki lished between 1979 a
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Table 10-1. Complete Response Rates
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194 R. Komaki twice daily to a tota
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196 R. Komaki Intergroup study 0096
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198 R. Komaki Figure 10-1. Survival
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200 R. Komaki cisplatin with concur
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202 R. Komaki KEY PRACTICE POINTS
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204 R. Komaki tients (Pts) with lim
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206 R. Komaki Wagner H, Kim K, John
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208 G.R. Blumenschein, Jr. recurs a
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210 G.R. Blumenschein, Jr. syndrome
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212 G.R. Blumenschein, Jr. toxicity
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214 G.R. Blumenschein, Jr. the year
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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258 E.S. Kim and F.R. Khuri A secon
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260 E.S. Kim and F.R. Khuri Smoking
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262 E.S. Kim and F.R. Khuri Reversa
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264 E.S. Kim and F.R. Khuri yet to
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266 E.S. Kim and F.R. Khuri nation
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268 E.S. Kim and F.R. Khuri Methodo
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270 E.S. Kim and F.R. Khuri have be
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272 E.S. Kim and F.R. Khuri the tre
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274 E.S. Kim and F.R. Khuri changes
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276 E.S. Kim and F.R. Khuri KEY PRA
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278 E.S. Kim and F.R. Khuri Hong WK
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15 MOLECULAR EVENTS IN LUNG CANCER
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282 W.N. Hittelman, J.M. Kurie, and
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300 Index Anterior spinal column re
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302 Index Cardiac murmurs, 104 Card
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304 Index Diagnosis. See also under
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306 Index Growth. See Tumor growth
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308 Index Magnetic resonance (MR) i
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310 Index p16 gene, 285 p19 arf gen
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312 Index Pulmonary resection (cont
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314 Index Squamous metaplasia, 263-
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316 Index Vitamin A, 262 Vocal cord
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