Lung Cancer.pdf

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Index 301 pretreatment imaging evaluation, 14, 31, 87-88 prophylactic irradiation, 135, 188 surgery, 19 Breast cancer, 5, 178 Bronchial arteries, 6 Bronchial brushing, 60-61 Bronchial epithelial metaplasia, 262 Bronchial sleeve resection, 227 Bronchial stump dehiscence, 252-253 Bronchial washings, 60-61 Bronchioalveolar adenocarcinoma (BAC), 74 Bronchiolization of the alveolar septae, 66 Bronchioloalveolar adenoma. See Atypical adenomatous hyperplasia Bronchodilators, 87 Bronchogenic carcinomas, 68 Bronchoplasty, 132-133, 227 Bronchopleural fistula, 252 Bronchoscopy extrinsic compression of airway, 235-236 fiber-optic, 7 flexible fiber-optic, 33-34 fluorescence, 13 intraluminal tumors, 236-237 mediastinal lymph nodes, 14 pretreatment evaluation, 14 Bronchus, obstruction of, 153 C225 (cetuximab), 274, 293 Cachexia, 28, 237-238. See also Anorexia; Appetite; Weight loss Calcification, 38-40 Calretinin, 77 Carbon dioxide. See Diffusing capacity Carbon monoxide. See Diffusing capacity Carbonated beverages, 246 Carboplatin NSCLC, 18, 161 paclitaxel and, 163 preoperative, 109-110 second-generation agents and, 170-173 third-generation agents and, 167, 170-173 Carcinoembryonic antigen, 29, 66, 77 Carcinogen exposure, 283 Carcinogenesis, models of, 258-259 Carcinoid tumor, 64, 70-71, 71-72, 78 Carcinoma acinic cell, 76 adenoid cystic, 76, 227 adenosquamous, 64, 74 basaloid, 74 bronchioalveolar adenocarcinoma, 74 bronchogenic, 68 epimyoepithelial, 76 head and neck squamous cell, 263, 272, 274 in situ, 62, 63, 65, 78, 283 large cell. See Large cell carcinoma mucoepidermoid, 76 nonmucinous bronchioalveolar adenocarcinoma, 66-67 pleomorphic, 75 with pleomorphic, sarcomatoid, or sarcomatous elements, 64, 75-76 salivary-gland type, 64, 76 sarcomatoid, 75, 78 segmental, 124, 126 with spindle and/or giant cells, 75 squamous cell. See Squamous cell carcinoma unclassified, 64 Carcinosarcoma, 75
302 Index Cardiac murmurs, 104 Cardiomyopathy, 248 Cardiovascular screening, 122 Carina, invasion of, 135, 136 Carofate (sucralfate) slurries, 245 -Carotene, 264, 268 -Carotene and Retinol Efficacy Trial (CARET), 268 Carotenoids, 262 Carotid bruits, 104 Catechins, 267 Catheter chronic indwelling pleural, 20, 230-236 epidural, 91, 93 Celecoxib (Celebrex), 267, 296 Cell cycle, 285-286, 296 Cellulitis, 254 Central nervous system (CNS). See also Brain; Spinal cord metastases, 27-28, 46, 198-200 radiographic evaluation, 31 Centromere-binding proteins, 293 Cervical mediastinoscopy, 12 Cetuximab (C225), 274, 293 Chamberlain procedure, 12 Chemical shift analysis, 46, 47 Chemoprevention, 260-275, 290 Chemoradiation therapy limited-stage SCLC, 190-201 NSCLC, 20-22, 120, 148-152 preoperative, 244 RTOG 91-06 trial, 149, 150 RTOG 92-04 trial, 150 RTOG 93-09 trial, 131-132 RTOG 94-10 trial, 151-152 side effects of, 247 T4N0–1 tumors, 135 Chemotherapy. See also entries for specific drugs agent selection, 164-178 alternating regimens, 214-215 assessment of patients after, 36 biologicals, 178-179 combination, 20 dosages in limited-stage SCLC, 194 dose intensification, 215 downstaging with, 136 neoadjuvant, 19, 109-110, 243-244 NSCLC, 18, 105, 108-110, 120, 158-185 older patients and, 162 postoperative, 244 practice guidelines, 87-88 radiation therapy and. See Chemoradiation therapy refractory or recurrent disease, 215-217 SCLC, 189-201, 207-219 timing and duration, 163-164 T3N1 Pancoast tumors, 130 Chest pain, 7, 26, 27, 209 Chest tube drainage, 91 Chest wall en bloc resection, 226 invasion of, 6, 43, 44 pain at diagnosis, 7 radiographic evaluations, 31 resection, 128 Chondrosarcoma, 75 Chromium, 6 Chromogranin stain, 71, 72, 77 Chromosomes, 66, 78. See also Loss of heterozygosity Chronic indwelling pleural catheter, 20, 230-236 Chronic obstructive pulmonary disease, 228 Cigarette smoking. See Smoking 13-cis-Retinoic acid, 262, 269-270 Cisplatin combination therapy, 21 etoposide and, 166 gemcitabine and, 166, 168 irinotecan and, 166
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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66 P. Tamboli and J.Y. Ro Atypical
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68 P. Tamboli and J.Y. Ro Diffuse I
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70 P. Tamboli and J.Y. Ro noma. Cig
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72 P. Tamboli and J.Y. Ro Figure 4-
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74 P. Tamboli and J.Y. Ro alone. BA
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76 P. Tamboli and J.Y. Ro Other Mal
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78 P. Tamboli and J.Y. Ro Electron
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80 P. Tamboli and J.Y. Ro Niho S, Y
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82 Y. De Jesus and G.L. Walsh Chapt
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84 Y. De Jesus and G.L. Walsh Figur
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86 Y. De Jesus and G.L. Walsh guide
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88 Y. De Jesus and G.L. Walsh with
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Figure 5-2. Patient “pathway to r
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94 Y. De Jesus and G.L. Walsh Recov
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98 Y. De Jesus and G.L. Walsh KEY P
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100 Y. De Jesus and G.L. Walsh Jenn
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102 W.R. Smythe nation for these su
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104 W.R. Smythe patient reports of
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106 W.R. Smythe bar or limited lung
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108 W.R. Smythe hospitals for 149 p
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110 W.R. Smythe Figure 6-1. Postsur
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112 W.R. Smythe nant neoplasms has
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114 W.R. Smythe Future Directions F
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116 W.R. Smythe Henschke CI, McCaul
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7 SURGICAL TREATMENT OF LOCALLY ADV
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120 S.G. Swisher Treatment Options
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122 S.G. Swisher Initial Assessment
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124 S.G. Swisher Figure 7-1. Region
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126 S.G. Swisher Table 7-2. (contin
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128 S.G. Swisher upper paratracheal
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130 S.G. Swisher is performed only
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132 S.G. Swisher chance for long-te
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134 S.G. Swisher Pancoast tumors th
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136 S.G. Swisher A B Figure 7-2. Do
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138 S.G. Swisher a combination of t
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140 S.G. Swisher Dartevelle PG, Cha
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8 NONSURGICAL TREATMENT OF EARLY-ST
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144 R. Komaki morbid conditions pre
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146 R. Komaki and 26 patients had c
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148 R. Komaki Around 1998, by using
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150 R. Komaki Table 8-5. Survival a
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152 R. Komaki A total of 610 patien
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154 R. Komaki tially obstructed air
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156 R. Komaki report of Radiation T
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9 TREATMENT OF PATIENTS WITH ADVANC
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160 R. Zinner chemotherapy, in pati
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Table 9-1. Chemotherapy in Older Pa
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164 R. Zinner results of additional
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Table 9-3. Third-Generation-Agent M
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Table 9-4. Third-Generation Agents
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Table 9-5. Third-Generation Platinu
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Table 9-6. Comparisons between Diff
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174 R. Zinner may play an important
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Table 9-8. Third-Generation Cisplat
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178 R. Zinner wards higher survival
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180 R. Zinner KEY PRACTICE POINTS
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182 R. Zinner DeVore RF, Fehrenbach
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184 R. Zinner Perng RP, Chen YM, Mi
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10 TREATMENT OF LIMITED-STAGE SMALL
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188 R. Komaki Age is not a signific
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190 R. Komaki lished between 1979 a
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Table 10-1. Complete Response Rates
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194 R. Komaki twice daily to a tota
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196 R. Komaki Intergroup study 0096
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198 R. Komaki Figure 10-1. Survival
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200 R. Komaki cisplatin with concur
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202 R. Komaki KEY PRACTICE POINTS
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204 R. Komaki tients (Pts) with lim
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206 R. Komaki Wagner H, Kim K, John
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208 G.R. Blumenschein, Jr. recurs a
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210 G.R. Blumenschein, Jr. syndrome
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212 G.R. Blumenschein, Jr. toxicity
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214 G.R. Blumenschein, Jr. the year
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216 G.R. Blumenschein, Jr. is chara
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218 G.R. Blumenschein, Jr. new cyto
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12 PALLIATIVE CARE IN PATIENTS WITH
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222 J.B. Putnam, Jr. therapy. Patie
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224 J.B. Putnam, Jr. tion—includi
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226 J.B. Putnam, Jr. rates were 47%
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228 J.B. Putnam, Jr. Dyspnea The ma
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230 J.B. Putnam, Jr. Small-bore cat
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232 J.B. Putnam, Jr. A B Figure 12-
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234 J.B. Putnam, Jr. C D Figure 12-
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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Page 295 and 296: 282 W.N. Hittelman, J.M. Kurie, and
Page 313: 300 Index Anterior spinal column re
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Page 319 and 320: 306 Index Growth. See Tumor growth
Page 321 and 322: 308 Index Magnetic resonance (MR) i
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Page 327 and 328: 314 Index Squamous metaplasia, 263-
Page 329: 316 Index Vitamin A, 262 Vocal cord
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