Lung Cancer.pdf

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Treatment of Patients with Advanced Non–Small Cell Lung Cancer 185 Takiguchi Y, Nagao K, Nishiwaki YK, et al. The final results of a randomized phase III trial comparing irinotecan (CPT-11) and cisplatin (CDDP) with vindesine (VDS) and CDDP in advanced non-small-cell lung cancer (NSCLC). Ninth World Conference on Lung Cancer 2000. Abstract 89. Van Meerbeeck JP, Smit EF, Lianes P, et al. A EORTC randomized phase III trial of three chemotherapy regimens in advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2001;42. Abstract 1228. von Pawel J, von Roemeling R, Gatzemeier U, et al. Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: a report of the international CATAPULT I study group. Cisplatin and tirapazamine subjects with advanced previously untreated non-small-cell lung tumors. J Clin Oncol 2000;18:1351–1359. Wozniak AJ, Crowley JJ, Balcerzak SP, et al. Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer: a Southwest Oncology Group study. J Clin Oncol 1998;16:2459–2465. Yuen A, Halsey J, Fisher G, et al. A Phase I/II trial of ISIS 3521, an antisense inhibitor of pkc-alpha, with carboplatin and paclitaxel in non-small cell lung cancer. Proc Am Soc Clin Oncol 2001. Abstract 1234.
10 TREATMENT OF LIMITED-STAGE SMALL CELL LUNG CANCER Ritsuko Komaki Chapter Overview ....................................................................................... 186 Introduction ................................................................................................. 187 Prognostic Factors........................................................................................ 187 Initial Workup .............................................................................................. 188 Treatment ...................................................................................................... 189 Rationale for the Current Treatment Approach ................................ 189 Thoracic Radiation Therapy ........................................................... 189 Chemotherapy .................................................................................. 189 Chemotherapy and Thoracic Radiation Therapy in Combination ............................................................................ 190 Concurrent Chemotherapy and Thoracic Radiation Therapy ... 190 Delivery of Thoracic Radiation Therapy Early in the Course of Treatment ......................................................... 194 Chemotherapy Dose ........................................................................ 195 Volume Irradiated ............................................................................ 195 Fractionation of Radiation Therapy ............................................... 195 Radiation Dose to the Thorax ......................................................... 197 Prophylactic Cranial Irradiation .................................................... 198 M.D. Anderson Treatment Approach.................................................. 200 Assessments during Treatment ................................................................. 201 Response Assessment ................................................................................. 202 Follow-up after Treatment ......................................................................... 202 Future Directions ......................................................................................... 202 Key Practice Points ..................................................................................... 202 Suggested Readings .................................................................................... 203 Chapter Overview During the past decade, there have been major advances in the treatment of limited-stage small cell lung cancer (SCLC). Trials comparing the combination of chemotherapy and thoracic radiation therapy (TRT) with chemotherapy alone have shown that combination therapy improves survival rates.
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Lung Cancer Frank V. Fossella, MD R
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Frank V. Fossella, MD Department of
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vi Foreword possible. Since the res
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x Contents Chapter 7 Surgical Treat
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xii Contributors Joe B. Putnam, Jr.
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2 J.B. Putnam, Jr., F.V. Fossella,
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26 F.V. Fossella common sites of lu
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28 F.V. Fossella history and physic
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30 F.V. Fossella Computed Tomograph
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32 F.V. Fossella Pulmonary Function
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34 F.V. Fossella The use of flexibl
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36 R.F. Munden and J.J. Erasmus hav
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38 R.F. Munden and J.J. Erasmus che
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40 R.F. Munden and J.J. Erasmus tha
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42 R.F. Munden and J.J. Erasmus (Gu
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44 R.F. Munden and J.J. Erasmus A B
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46 R.F. Munden and J.J. Erasmus in
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48 R.F. Munden and J.J. Erasmus Pat
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50 R.F. Munden and J.J. Erasmus D C
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52 R.F. Munden and J.J. Erasmus A B
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54 R.F. Munden and J.J. Erasmus Bol
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56 R.F. Munden and J.J. Erasmus Swe
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58 P. Tamboli and J.Y. Ro Chapter O
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60 P. Tamboli and J.Y. Ro Figure 4-
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62 P. Tamboli and J.Y. Ro Postopera
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64 P. Tamboli and J.Y. Ro Table 4-1
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66 P. Tamboli and J.Y. Ro Atypical
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68 P. Tamboli and J.Y. Ro Diffuse I
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70 P. Tamboli and J.Y. Ro noma. Cig
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72 P. Tamboli and J.Y. Ro Figure 4-
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74 P. Tamboli and J.Y. Ro alone. BA
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76 P. Tamboli and J.Y. Ro Other Mal
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78 P. Tamboli and J.Y. Ro Electron
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80 P. Tamboli and J.Y. Ro Niho S, Y
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82 Y. De Jesus and G.L. Walsh Chapt
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84 Y. De Jesus and G.L. Walsh Figur
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86 Y. De Jesus and G.L. Walsh guide
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88 Y. De Jesus and G.L. Walsh with
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Figure 5-2. Patient “pathway to r
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94 Y. De Jesus and G.L. Walsh Recov
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98 Y. De Jesus and G.L. Walsh KEY P
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100 Y. De Jesus and G.L. Walsh Jenn
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102 W.R. Smythe nation for these su
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104 W.R. Smythe patient reports of
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106 W.R. Smythe bar or limited lung
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108 W.R. Smythe hospitals for 149 p
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110 W.R. Smythe Figure 6-1. Postsur
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112 W.R. Smythe nant neoplasms has
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114 W.R. Smythe Future Directions F
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116 W.R. Smythe Henschke CI, McCaul
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7 SURGICAL TREATMENT OF LOCALLY ADV
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120 S.G. Swisher Treatment Options
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122 S.G. Swisher Initial Assessment
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124 S.G. Swisher Figure 7-1. Region
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126 S.G. Swisher Table 7-2. (contin
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128 S.G. Swisher upper paratracheal
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130 S.G. Swisher is performed only
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132 S.G. Swisher chance for long-te
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Page 151 and 152: 138 S.G. Swisher a combination of t
Page 153 and 154: 140 S.G. Swisher Dartevelle PG, Cha
Page 155 and 156: 8 NONSURGICAL TREATMENT OF EARLY-ST
Page 157 and 158: 144 R. Komaki morbid conditions pre
Page 159 and 160: 146 R. Komaki and 26 patients had c
Page 161 and 162: 148 R. Komaki Around 1998, by using
Page 163 and 164: 150 R. Komaki Table 8-5. Survival a
Page 165 and 166: 152 R. Komaki A total of 610 patien
Page 167 and 168: 154 R. Komaki tially obstructed air
Page 169 and 170: 156 R. Komaki report of Radiation T
Page 171 and 172: 9 TREATMENT OF PATIENTS WITH ADVANC
Page 173 and 174: 160 R. Zinner chemotherapy, in pati
Page 175 and 176: Table 9-1. Chemotherapy in Older Pa
Page 177 and 178: 164 R. Zinner results of additional
Page 179 and 180: Table 9-3. Third-Generation-Agent M
Page 181 and 182: Table 9-4. Third-Generation Agents
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Page 185 and 186: Table 9-6. Comparisons between Diff
Page 187 and 188: 174 R. Zinner may play an important
Page 189 and 190: Table 9-8. Third-Generation Cisplat
Page 191 and 192: 178 R. Zinner wards higher survival
Page 193 and 194: 180 R. Zinner KEY PRACTICE POINTS
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Page 205 and 206: Table 10-1. Complete Response Rates
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Page 211 and 212: 198 R. Komaki Figure 10-1. Survival
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Page 215 and 216: 202 R. Komaki KEY PRACTICE POINTS
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Page 219 and 220: 206 R. Komaki Wagner H, Kim K, John
Page 221 and 222: 208 G.R. Blumenschein, Jr. recurs a
Page 223 and 224: 210 G.R. Blumenschein, Jr. syndrome
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Page 231 and 232: 218 G.R. Blumenschein, Jr. new cyto
Page 233 and 234: 12 PALLIATIVE CARE IN PATIENTS WITH
Page 235 and 236: 222 J.B. Putnam, Jr. therapy. Patie
Page 237 and 238: 224 J.B. Putnam, Jr. tion—includi
Page 239 and 240: 226 J.B. Putnam, Jr. rates were 47%
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236 J.B. Putnam, Jr. B Figure 12-3.
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238 J.B. Putnam, Jr. KEY PRACTICE P
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240 J.B. Putnam, Jr. Rendina EA, De
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242 A.A. Vaporciyan, J.F. Kelly, an
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14 PREVENTION AND EARLY DETECTION O
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258 E.S. Kim and F.R. Khuri A secon
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260 E.S. Kim and F.R. Khuri Smoking
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262 E.S. Kim and F.R. Khuri Reversa
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264 E.S. Kim and F.R. Khuri yet to
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266 E.S. Kim and F.R. Khuri nation
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268 E.S. Kim and F.R. Khuri Methodo
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270 E.S. Kim and F.R. Khuri have be
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272 E.S. Kim and F.R. Khuri the tre
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274 E.S. Kim and F.R. Khuri changes
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276 E.S. Kim and F.R. Khuri KEY PRA
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278 E.S. Kim and F.R. Khuri Hong WK
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15 MOLECULAR EVENTS IN LUNG CANCER
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282 W.N. Hittelman, J.M. Kurie, and
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300 Index Anterior spinal column re
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302 Index Cardiac murmurs, 104 Card
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304 Index Diagnosis. See also under
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306 Index Growth. See Tumor growth
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308 Index Magnetic resonance (MR) i
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310 Index p16 gene, 285 p19 arf gen
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312 Index Pulmonary resection (cont
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314 Index Squamous metaplasia, 263-
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316 Index Vitamin A, 262 Vocal cord
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