Review of the Food-borne Zoonoses Research ... - ARCHIVE: Defra

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Four published papers have come out of this project, two on poultry and two on pigs. The poultry work has rapidly been overtaken by alternative vaccine approaches. The pig work is still continuing, with the aim of solving problems specific to the UK. Any future work should be done with full involvement of the industry. 56
Project code: OZ0135 Project title: Epidemiological studies of multiple-resistant Salmonella Typhimurium DT104 in cattle Start date (dd/mm/yy): 01/04/1997 End date (dd/mm/yy): 31/03/2002 £523,530 Total cost: Affiliation: Veterinary Laboratories Agency Abstract of research This 5-year epidemiological project aimed to provide a better understanding of the epidemiology of multiple-resistant (MR) Salmonella Typhimurium DT 104 and other Salmonella infections in cattle herds. The project started during an epidemic of MR S. Typhimurium DT 104 in cattle, and increasing numbers of human infections with this organism, in the 1990s in Great Britain. The original proposal included an intervention study to test the effectiveness of control measures in cattle herds, but this was replaced with additional epidemiological studies because there was a marked decline in reported cases of this organism in cattle during the study. The studies demonstrated: 1. Salmonella infection of dairy herds in England and Wales was common but most herds were infected with serotypes unusual in human cases. 2. Infection was clustered geographically and more common in large herds 3. Management risk factors were identified providing evidence for control 4. Herds with clinical outbreaks of S Typhimurium DT104 did not usually experience further outbreaks but risk was higher than the general population 5. Biosecurity on dairy farms was generally poor and, at the time, it was considered difficult to improve sufficiently to control Salmonella 6 The standardised environmental sampling protocol used had many advantages in terms of cost and feasibility for the detection of Salmonella at the farm level and could be adapted for other livestock systems and organisms 7. Many Salmonella infections in cattle herds will be unreported by routine surveillance of laboratory submissions for clinical diagnoses. It is unlikely that Salmonella will be eradicated from dairy farms in the short to medium term, and therefore human exposure to this organism originating from dairy farms should be minimised, for example by ensuring the proper pasteurisation of milk and provision of advice to all farm workers and visitors. There were numerous potential transmission routes for Salmonella, and other infections, within the structure of G.B dairy farms (e.g., high number of animal movements) and the industry (e.g., network of markets and dealers). Emerging serotypes (eg MR S. Newport) are likely to spread rapidly after introduction and effective intervention to limit their spread will be difficult. Emerging serotypes not associated with disease will not be readily identified by current surveillance. 57
Page 2 and 3:
Contents Section A - Introduction..
Page 4 and 5:
Review of the Food-borne Zoonoses (
Page 6 and 7: Plans for taking forward these prio
Page 8 and 9: Policy Objectives The key policy ob
Page 10 and 11: Figure 2. Laboratory reports of Sal
Page 12 and 13: Figure 4. Laboratory reports of Cam
Page 14 and 15: 6. Aims of the FBZ research review
Page 16 and 17: Section B - Review Summaries 16
Page 18 and 19: epidemiology of Salmonella and anti
Page 20 and 21: There is a need to objectively asse
Page 22 and 23: 2. Campylobacter review summary 2.1
Page 24 and 25: for this organism. Research within
Page 26 and 27: 3. E. coli review summary 3.1 Succe
Page 28 and 29: 4. Other zoonotic pathogens of inte
Page 30 and 31: Annex 1 - Projects Reviewed 30
Page 32 and 33: OZ0311 Conventional versus capillar
Page 34 and 35: OZ0402 OZ0404 OZ0405 OZ0407 OZ0604
Page 36 and 37: OZ0704 OZ0705 OZ0706 OZ0707 Quantif
Page 38 and 39: Annex 2 - Project Abstracts and Pro
Page 40 and 41: To test the suitability of the AFLP
Page 42 and 43: Project code: OZ0324 Project title:
Page 46 and 47: Review Summary The knowledge that t
Page 48 and 49: Review Summary The project was felt
Page 52 and 53: It is clear that the EC legislative
Page 54 and 55: if the vaccines currently available
Page 58 and 59: Review Summary This epidemiological
Page 60 and 61: Project code: OZO316 Project title:
Page 64 and 65: agricultural industry/public health
Page 66 and 67: testing laboratories. In addition,
Page 68 and 69: animal pathogen but is a human path
Page 70 and 71: esearch has also substantially impr
Page 72 and 73: to elucidate the antigenic repertoi
Page 74 and 75: and have contributed to our underst
Page 76 and 77: Fundamental issues concerning the f
Page 78 and 79: Review summary Project OZ0606 focus
Page 80 and 81: Abstract of research OZ0608 The ado
Page 82 and 83: thinning process for molecular trac
Page 84 and 85: Project code: LK0665 Project title:
Page 86 and 87: Review summary While poultry meat i
Page 88 and 89: Review summary A key aim of this pr
Page 90 and 91: Review summary This project aimed t
Page 96 and 97: Project code: OZ0138C Project title
Page 102 and 103: Abstract of research Projects OZ070
Page 104 and 105: produced were both relevant and imp
Page 106 and 107:
List of External Reviewers. Mr. Pau
Page 108 and 109:
Review of Defra’s FBZ Research Pr
Page 110 and 111:
Review of Defra’s FBZ Research Pr
Page 112 and 113:
Annex 5 - Review Timetable 112
Page 114 and 115:
11.45 - 12.00 Bovine and Porcine Fo
Page 116:
Campylobacter Other 11.50 - 12.05 P
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