Review of the Food-borne Zoonoses Research ... - ARCHIVE: Defra

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esearch has also substantially improved our understanding of the epidemiology of Neospora caninum. There is no requirement for further funding from this programme because the results have shown that the organism has no real zoonotic significance. The team have built up significant expertise on this parasite and it is for another programme to consider whether further funding on purely animal health/animal welfare grounds might be justified. 70
Campylobacter Research Projects Project code: OZ0604 Project title: Characterisation of strain variation in Campylobacter jejuni. Start date (dd/mm/yy): 01/04/1999 End date (dd/mm/yy): 30/09/2004 £774,549 Total cost: Affiliation: University of Oxford Sub-contractor(s): HPA Project code: OZ0611 Project title: Development of a comprehensive MLST database for assessment of Campylobacter risk factors Start date (dd/mm/yy): 01/07/2005 End date (dd/mm/yy): 30/06/2008 £503,312.00 Total cost: Affiliation: University of Oxford Sub-contractor(s): Abstract of research OZ0604 Campylobacter species, particularly Campylobacter jejuni, are a major cause of human gastro-enteritis in the UK and elsewhere. In the majority of infections, which are sporadic, the precise epidemiology is not determined, although several food producing animals have been implicated as important sources of infection. The epidemiology of zoonotic transmission of C. jejuni to man remains obscure due to inconsistencies within and between the various phenotyping and molecular typing methods used to characterise C. jejuni isolates. These inconsistencies arise from the inability of the current methods to unambiguously define strain types and genetic lineages, and the lack of precise understanding of the variation which they index. This work will address these problems, definitively establishing the range and mechanisms of genetic variability in populations of C. jejuni, by the application of the most recently developed sequence typing technologies to a minimum of 1500 isolates, representative of those obtained from human infections, farm animals, the human food chain, and the environment. Multilocus sequence typing (MLST), which identifies strain relationships on the basis of neutral variation in housekeeping genes, and antigen gene sequence typing, which will be used 71
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Contents Section A - Introduction..
Page 4 and 5:
Review of the Food-borne Zoonoses (
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Plans for taking forward these prio
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Policy Objectives The key policy ob
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Figure 2. Laboratory reports of Sal
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Figure 4. Laboratory reports of Cam
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6. Aims of the FBZ research review
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Section B - Review Summaries 16
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epidemiology of Salmonella and anti
Page 20 and 21: There is a need to objectively asse
Page 22 and 23: 2. Campylobacter review summary 2.1
Page 24 and 25: for this organism. Research within
Page 26 and 27: 3. E. coli review summary 3.1 Succe
Page 28 and 29: 4. Other zoonotic pathogens of inte
Page 30 and 31: Annex 1 - Projects Reviewed 30
Page 32 and 33: OZ0311 Conventional versus capillar
Page 34 and 35: OZ0402 OZ0404 OZ0405 OZ0407 OZ0604
Page 36 and 37: OZ0704 OZ0705 OZ0706 OZ0707 Quantif
Page 38 and 39: Annex 2 - Project Abstracts and Pro
Page 40 and 41: To test the suitability of the AFLP
Page 42 and 43: Project code: OZ0324 Project title:
Page 46 and 47: Review Summary The knowledge that t
Page 48 and 49: Review Summary The project was felt
Page 52 and 53: It is clear that the EC legislative
Page 54 and 55: if the vaccines currently available
Page 56 and 57: Four published papers have come out
Page 58 and 59: Review Summary This epidemiological
Page 60 and 61: Project code: OZO316 Project title:
Page 64 and 65: agricultural industry/public health
Page 66 and 67: testing laboratories. In addition,
Page 68 and 69: animal pathogen but is a human path
Page 72 and 73: to elucidate the antigenic repertoi
Page 74 and 75: and have contributed to our underst
Page 76 and 77: Fundamental issues concerning the f
Page 78 and 79: Review summary Project OZ0606 focus
Page 80 and 81: Abstract of research OZ0608 The ado
Page 82 and 83: thinning process for molecular trac
Page 84 and 85: Project code: LK0665 Project title:
Page 86 and 87: Review summary While poultry meat i
Page 88 and 89: Review summary A key aim of this pr
Page 90 and 91: Review summary This project aimed t
Page 96 and 97: Project code: OZ0138C Project title
Page 102 and 103: Abstract of research Projects OZ070
Page 104 and 105: produced were both relevant and imp
Page 106 and 107: List of External Reviewers. Mr. Pau
Page 108 and 109: Review of Defra’s FBZ Research Pr
Page 110 and 111: Review of Defra’s FBZ Research Pr
Page 112 and 113: Annex 5 - Review Timetable 112
Page 114 and 115: 11.45 - 12.00 Bovine and Porcine Fo
Page 116: Campylobacter Other 11.50 - 12.05 P
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