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158 SCIENTIFIC REPORTS | Publications • Sun,H., Spring,S., Lapidus,A., Davenport,K., Del Rio,T.G., Tice,H., Nolan,M., Copeland,A., Cheng,J.F., Lucas,S., Tapia,R., Goodwin,L., Pitluck,S., Ivanova,N., Pagani,I., Mavromatis,K., Ovchinnikova,G., Pati,A., Chen,A., Palaniappan,K., Hauser,L., Chang,Y.J., Jeffries,C.D., Detter,J.C., Han,C., Rohde,M., Brambilla,E., Göker,M., Woyke,T., Bristow,J., Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., Klenk,H.P., & Land,M. (2010) Complete genome sequence of Desulfarculus baarsii type strain (2st14). Standards in Genomic Sciences 3, 276-284. • Sun,H., Lapidus,A., Nolan,M., Lucas,S., Del Rio,T.G., Tice,H., Cheng,J.F., Tapia,R., Han,C., Goodwin,L., Pitluck,S., Pagani,I., Ivanova,N., Mavromatis,K., Mikhailova,N., Pati,A., Chen,A., Palaniappan,K., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Djao,O.D., Rohde,M., Sikorski,J., Göker,M., Woyke,T., Bristow,J., Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., & Klenk,H.P. (2010) Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509). Standards in Genomic Sciences 3, 325-336. • Tegtmeyer,N., Hartig,R., Delahay,R.M., Rohde,M., Brandt,S., Conradi,J., Takahashi,S., Smolka,A.J., Sewald,N., & Backert,S. (2010) A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. Journal of Biological Chemistry 285, 23515-23526. • Tice,H., Mayilraj,S., Sims,D., Lapidus,A., Nolan,M., Lucas,S., Glavina Del,R.T., Copeland,A., Cheng,J.F., Meincke,L., Bruce,D., Goodwin,L., Pitluck,S., Ivanova,N., Mavromatis,K., Ovchinnikova,G., Pati,A., Chen,A., Palaniappan,K., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Detter,J.C., Brettin,T., Rohde,M., Goker,M., Bristow,J., Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., Klenk,H.P., & Chen,F. (2010) Complete genome sequence of Nakamurella multipartita type strain (Y-104). Standards in Genomic Sciences 2, 168-175. • Tindall,B.J., Sikorski,J., Lucas,S., Goltsman,E., Copeland,A., Glavina Del,R.T., Nolan,M., Tice,H., Cheng,J.F., Han,C., Pitluck,S., Liolios,K., Ivanova,N., Mavromatis,K., Ovchinnikova,G., Pati,A., Fahnrich,R., Goodwin,L., Chen,A., Palaniappan,K., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Rohde,M., Göker,M., Woyke,T., Bristow,J., Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., Klenk,H.P., & Lapidus,A. (2010) Complete genome sequence of Meiothermus ruber type strain (21). Standards in Genomic Sciences 3, 26-36. • Traverso,F.R., Bohr,U.R.M., Oyarzabal,O.A., Rohde,M., Clarici,A., Wex,T., Kuester,D., Malfertheiner,P., Fox,J.G., & Backert,S. (2010) Morphologic, genetic, and biochemical characterization of Helicobacter magdeburgensis, a novel species isolated from the intestine of laboratory mice. Helicobacter 15, 403-415. • von Jan,M., Lapidus,A., Del Rio,T.G., Copeland,A., Tice,H., Cheng,J.F., Lucas,S., Chen,F., Nolan,M., Goodwin,L., Han,C., Pitluck,S., Liolios,K., Ivanova,N., Mavromatis,K., Ovchinnikova,G., Chertkov,O., Pati,A., Chen,A., Palaniappan,K., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Saunders,E., Brettin,T., Detter,J.C., Chain,P., Eichinger,K., Huber,H., Spring,S., Rohde,M., Göker,M., Wirth,R., Woyke,T., Bristow,J., Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., & Klenk,H.P. (2010) Complete genome sequence of Archaeoglobus profundus type strain (AV18). Standards in Genomic Sciences 2, 327-346. • Wirth,R., Sikorski,J., Brambilla,E., Misra,M., Lapidus,A., Copeland,A., Nolan,M., Lucas,S., Chen,F., Tice,H., Cheng,J.F., Han,C., Detter,J.C., Tapia,R., Bruce,D., Goodwin,L., Pitluck,S., Pati,A., Anderson,I., Ivanova,N., Mavromatis,K., Mikhailova,N., Chen,A., Palaniappan,K., Bilek,Y., Hader,T., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Tindall,B.J., Rohde,M., Göker,M., Bristow,J., Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., & Klenk,H.P. (2010) Complete genome sequence of Thermocrinis albus type strain (HI 11/12). Standards in Genomic Sciences 2, 194-202. • Yasawong,M., Teshima,H., Lapidus,A., Nolan,M., Lucas,S., Glavina Del,R.T., Tice,H., Cheng,J.F., Bruce,D., Detter,C., Tapia,R., Han,C., Goodwin,L., Pitluck,S., Liolios,K., Ivanova,N., Mavromatis,K., Mikhailova,N., Pati,A., Chen,A., Palaniappan,K., Land,M., Hauser,L., Chang,Y.J., Jeffries,C.D., Rohde,M., Sikorski,J., Pukall,R., Göker,M., Woyke,T., Bristow,J., Eisen,J.A., Markowitz,V., Hugenholtz,P., Kyrpides,N.C., & Klenk,H.P. (2010) Complete genome sequence of Arcanobacterium haemolyticum type strain (11018). Standards in Genomic Sciences 3, 126-135. • Bergmann,R., Dinkla,K., Nitsche-Schmitz,D.P., Graham,R.M., Luttge,M., Sanderson-Smith,M.L., Nerlich,A., Rohde,M., & Chhatwal,G.S.*. (2011) Biological functions of GCS3, a novel plasminogen-binding protein of Streptococcus dysgalactiae ssp. equisimilis. International Journal of Medical Microbiology 301, 157-164. • Fulde,M., Rohde,M., Hitzmann,A., Preissner,K.T., Nitsche- Schmitz,D.P., Nerlich,A., Chhatwal,G.S.*., & Bergmann,S. (2011) SCM, a novel M-like protein from Streptococcus canis, binds (mini)- plasminogen with high affinity and facilitates bacterial transmigration. Biochemical Journal 434, 523-535. • Härtel,T., Klein,M., Koedel,U., Rohde,M., Petruschka,L., & Hammerschmidt,S. (2011) Impact of glutamine transporters on pneumococcal fitness under infection-related conditions. Infection and Immunity 79, 44-58. • Lyszkiewicz,M., Zietara,N., Rohde,M., Gekara,N.O., Jablonska,J., Dittmar,K.E.*., & Weiss,S. (2011) SIGN-R1+MHC II+ cells of the splenic marginal zone--a novel type of resident dendritic cells. Journal of Leukocyte Biology 89, 607-615. • Gupta,A.K., Dharne,M.S., Rangrez,A.Y., Verma,P., Ghate,H.V., Rohde,M., Patole,M.S., & Shouche,Y.S. (2010) Ignatzschineria indica sp. nov. and Ignatzschineria ureaclastica sp. nov., isolated from adult flesh fly (Diptera: Sarcophagidae). International Journal of Systematic and Evolutionary Microbiology, in press. • von Jan,M., Riegger,N., Potter,G., Schumann,P., Verbarg,S., Sproer,C., Rohde,M., Lauer,B., Labeda,D.P., & Klenk,H.P. (2010) Kroppenstedtia eburnea gen. nov., sp. nov., a novel thermoactinomycete isolated by environmental screening, and emended description of the family Thermoactinomycetaceae Matsuo et al. 2006 emend. Yassin et al. 2009. International Journal of Systematic and Evolutionary Microbiology, in press. • Abel,J., Goldmann,O., Ziegler,C., Höltje,C., Smeltzer,M.S., Cheung,A.L., Bruhn,D., Rohde,M., & Medina,E. (2011) Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake. Journal of Innate Immunity, in press. • Hebecker,S., Arendt,W., Heinemann,I.U., Tiefenau,J.H., Nimtz,M., Rohde,M., Soll,D., & Moser,J. (2011) Alanyl-phosphatidylglycerol synthase: mechanism of substrate recognition during tRNA-dependent lipid modification in Pseudomonas aeruginosa. Molecular Microbiology, in press. • Willenborg,J., Fulde,M., de,G.A., Rohde,M., Smith,H.E., Valentin- Weigand,P., & Goethe,R. (2011) Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis. Microbiology, in press. RG Infection Immunology | Priv.-Doz. Dr. Eva Medina • Goldmann,O., Lehne,S., & Medina,E. (2010) Age-related susceptibility to Streptococcus pyogenes infection in mice: underlying immune dysfunction and strategy to enhance immunity. Journal of Pathology 220, 521-529. • Goldmann,O., Hertzen,E., Hecht,A., Schmidt,H., Lehne,S., Norrby- Teglund,A., & Medina,E. (2010) Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes. Journal of Immunology 185, 2372-2381. • Loof,T.G., Goldmann,O., Gessner,A., Herwald,H., & Medina,E. (2010) Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88. American Journal of Pathology 176, 754-763. • Medina,E. & Goldmann,O. (2011) In vivo and ex vivo protocols for measuring the killing of extracellular pathogens by macrophages. Current Protocols in Immunology Chapter 14, Unit14.19. • Medina,E. (2010) Murine model of cutaneous infection with Streptococcus pyogenes. Methods in Molecular Biology 602, 395-403. • Medina,E. (2010) Murine model of pneumococcal pneumonia. Methods in Molecular Biology 602, 405-410.
SCIENTIFIC REPORTS | Publications 159 • Medina,E. (2010) Murine model of polymicrobial septic peritonitis using cecal ligation and puncture (CLP). Methods in Molecular Biology 602, 411-415. • Nippe,N., Varga,G., Holzinger,D., Loffler,B., Medina,E., Becker,K., Roth,J., Ehrchen,J.M., & Sunderkotter,C. (2010) Subcutaneous infection with S. aureus in mice reveals association of resistance with influx of neutrophils and Th2 response. Journal of Investigative Dermatology 131, 125-132. • Tuchscherr,L., Medina,E., Hussain,M., Volker,W., Heitmann,V., Niemann,S., Holzinger,D., Roth,J., Proctor,R.A., Becker,K., Peters,G., & Loffler,B. (2011) Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection. EMBO Molecular Medicine 3, 129-141. • Medina,E. (2011) Novel experimental models for dissecting genetic susceptibility of superantigen-mediated diseases. In: Superantigens: Molecular Basis for Their Role in Human Disease (Kotb,M. & Frase,J.D., eds.), ASM Press, Washington, D.C., in press. • Abel,J., Goldmann,O., Ziegler,C., Höltje,C., Smeltzer,M.S., Cheung,A.L., Bruhn,D., Rohde,M., & Medina,E. (2011) Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake. Journal of Innate Immunity, in press. RG Microbial Interactions and Processes | Prof. Dr. Dietmar Pieper • Gomes,N.C., Flocco,C.G., Costa,R., Junca,H., Vilchez,R., Pieper,D.H.*., Krogerrecklenfort,E., Paranhos,R., Mendonca-Hagler,L.C., & Smalla,K. (2010) Mangrove microniches determine the structural and functional diversity of enriched petroleum hydrocarbon-degrading consortia. FEMS Microbiology Ecology 74, 276-290. • Marin,M., Perez-Pantoja,D., Donoso,R., Wray,V., Gonzalez,B., & Pieper,D.H.*. (2010) Modified 3-oxoadipate pathway for the biodegradation of methylaromatics in Pseudomonas reinekei MT1. Journal of Bacteriology 192, 1543-1552. • Vilchez-Vargas,R., Junca,H., & Pieper,D.H.*. (2010) Metabolic networks, microbial ecology and ‘omics’ technologies: towards understanding in situ biodegradation processes. Environental Microbiology 12, 3089-3104. • Wos-Oxley,M.L., Plumeier,I., von,E.C., Taudien,S., Platzer,M., Vilchez- Vargas,R., Becker,K., & Pieper,D.H.*. (2010) A poke into the diversity and associations within human anterior nare microbial communities. ISME Journal 4, 839-851. • Junca,H. & Pieper,D.H.* (2011) Functional marker gene assays for hydrocarbon degrading microbial communities - aerobic. In: Handbook of Hydrocarbon Microbiology (Timmis,K.N., ed.), Springer, in press. • Palleroni,N., Pieper,D.H.*, & Moore,E.R.B. (2011) Microbiology of hydrocarbon-degrading Pseudomonas. In: Handbook of Hydrocarbon Microbiology (Timmis,K.N., ed.), Springer, in press. • Perez-Pantoja,D., Gonzalez,B., & Pieper,D.H.* (2011) Aerobic degradation of aromatic hydrocarbons. In: Handbook of Hydrocarbon Microbiology (Timmis,K.N., ed.), Springer, in press. • Pieper,D.H.*., Gonzalez,B., Camara,B., Perez-Pantoja,D., & Reineke,W. (2011) Aerobic degradation of chloroaromatics. In: Handbook of Hydrocarbon Microbiology (Timmis,K.N., ed.), Springer, in press. • Seeger,M. & Pieper,D.H.* (2011) Genetics of biphenyl biodegradation and co-metabolism of PCBs. In: Handbook of Hydrocarbon Microbiology (Timmis,K.N., ed.), Springer, in press. • Becker,K., Mutter,W., Daniel,R., Rudack,C., Peschel,A., & Pieper,D. (2011) Bakterielle Untermieter in der menschlichen Nase. GenomX- Press, in press. • Pfingsten-Würzburg,S., Pieper,D., Bautsch,W., & Probst-Kepper,M. (2011) Prevelence and molecular epidemiology of meticillin-resistant Staphylococcus aureus in nursing home residents in northern Germany. Journal of Hospital Infection, in press. • Vilchez,R., Gomez-Silvan,C., Purswani,J., Gonzalez-Lopez,J., & Rodelas,B. (2011) Characterization of bacterial communities exposed to Cr(III) and Pb(II) in submerged fixed-bed biofilms for groundwater treatment. Ecotoxicology, in press. Dept. of Vaccinology and Applied Microbiology | Prof. Dr. Dr. Carlos Guzmán • Becker,P.D., Royo,J.L., & Guzmán,C.A.* (2010) Exploitation of prokaryotic expression systems based on the salicylate-dependent control circuit encompassing nahRPsal::xylS2 for biotechnological applications. Bioengineered Bugs 1, 246-253. • Becker,P.D., Legrand,N., van Geelen,C.M., Noerder,M., Huntington,N.D., Lim,A., Yasuda,E., Diehl,S.A., Scheeren,F.A., Ott,M., Weijer,K., Wedemeyer,H., Di Santo,J.P., Beaumont,T., Guzmán,C.A.*, & Spits,H. (2010) Generation of human antigen-specific monoclonal IgM antibodies using vaccinated “human immune system” mice. PLoS ONE 5. • Bjorkstrom,N.K., Riese,P., Heuts,F., Andersson,S., Fauriat,C., Ivarsson,M.A., Bjorklund,A.T., Flodstrom-Tullberg,M., Michaelsson,J., Rottenberg,M.E., Guzmán,C.A.*, Ljunggren,H.G., & Malmberg,K.J. (2010) Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education. Blood 116, 3853-3864. • Caro-Quintero,A., Deng,J., Auchtung,J., Brettar,I., Höfle,M.G.*, Klappenbach,J., & Konstantinidis,K.T. (2010) Unprecedented levels of horizontal gene transfer among spatially co-occurring Shewanella bacteria from the Baltic Sea. ISME Journal 5, 140. • Cazorla,S.I., Frank,F.M., Becker,P.D., Arnaiz,M., Mirkin,G.A., Corral,R.S., Guzmán,C.A.*, & Malchiodi,E.L. (2010) Redirection of the immune response to the functional catalytic domain of the cystein proteinase cruzipain improves protective immunity against Trypanosoma cruzi infection. Journal of Infectious Diseases 202, 136-144. • Chen,H.L., Lünsdorf,H., Hecht,H.J., & Tsai,H. (2010) Porcine pulmonary angiotensin I-converting enzyme-biochemical characterization and spatial arrangement of the N- and C-domains by three-dimensional electron microscopic reconstruction. Micron 41, 674-685. • Ebensen,T., Libanova,R., & Guzman,C.A.* (2010) Bis-(3’,5’)-cyclic di-GMP: promising adjuvant for vaccine design. In The Second Messenger Cyclic di-GMP (Wolf,A.J. & Visick,K.L.I., eds), pp. 311-319. ASM Press, Washington, D.C., USA. • Fritzer,A., Senn,B.M., Minh,D.B., Hanner,M., Gelbmann,D., Noiges,B., Henics,T., Schulze,K., Guzmán,C.A.*, Goodacre,J., von,G.A., Nagy,E., & Meinke,A.L. (2010) Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine. Infection and Immunity 78, 4051-4067. • Guzmán,C.A.*. (2010) Research needs in vaccinology. In: Handbook of Hydrocarbon and Lipid Microbiology (Timmis,K.N., ed.), Springer- Verlag, Berlin Heidelberg, pp. 3383-3385. • Guzmán,C.A.* (2010) Optimizing rational vaccine design. Microbial Biotechnology 2, 136-138. • Hahn,M.W., Lang,E., Brandt,U., Lünsdorf,H., Wu,Q.L., & Stackebrandt,E. (2010) Polynucleobacter cosmopolitanus sp. nov., freeliving planktonic bacteria inhabiting freshwater lakes and rivers. International Journal of Systematic and Evolutionary Microbiology 60, 166-173. • Kahlisch,L., Henne,K., Draheim,J., Brettar,I., & Höfle,M.G.* (2010) High-resolution in situ genotyping of Legionella pneumophila populations in drinking water by multiple-locus variable-number tandemrepeat analysis using environmental DNA. Applied and Environmental Microbiology 76, 6186-6195. • Kahlisch,L., Henne,K., Gröbe,L., Draheim,J., Höfle,M.G.*, & Brettar,I. (2010) Molecular analysis of the bacterial drinking water community with respect to live/dead status. Water Science and Technology 61, 9-14.
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RESEARCH REPORT 2006/2007 2010/2011
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SCIENTIFIC REPORTS 91 Infection and
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PORTRAIT 5 The task of the chemists
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FOREWORD | Prof. Dr. Dirk Heinz 7 F
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OBITUARY | Jürgen Wehland 9 Jürge
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SCIENTIFIC REPORTS FACTS AND FIGURE
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