Research Report 2010 2011 - Helmholtz-Zentrum für ...

FOREWORD 04 The Helmholtz Centre for Infection Research – a portrait
07 Foreword
08 Orbituary – Jürgen Wehland
FOCUS 12 The German Centre for Infection Research (DZIF) – a great chance for the HZI
15 Highlights 2010-2011
RESEARCH REVIEWS 22 Frontier runners of Hepatitis C Virus
30 The aging of the immune system: challenges and perspectives
36 Novel nanoparticle-based technology platform for the delivery of vaccine antigens
42 Mycobacterial phagosomes and innate immunity
SPECIAL FEATURES 48 Where would we be without DNA sequences?
52 Nuclear magnetic resonance spectroscopy, a major player in the arsenal
of platform technologies available in the HZI
60 International cooperation of Helmholtz Centre for Infection Research with
India and China: a success story
SCIENTIFIC REPORTS 64 INFECTION AND IMMUNITY
67 Microbial Pathogenesis
69 Structural analysis of virulence factors
70 Virulence factors of streptococci and pneumococci
71 Molecular mechanisms of intracellular trafficking,survival and persistence of streptococci
72 Analysis of protein networks induced by early host-pathogen interactions
73 Structural and mechanistical analysis of functional amyloids
74 Microtubule dynamics and bacterial pathogenesis
75 Function and regulation of Yersinia virulence factors
76 Structural characterisation of pathogen defence factors
77 Mycobacterial phagosomes and immunity
78 Molecular mechanisms of host-cell pathogen interactions
79 Signalling to actin dynamics
80 Generation and exploitation of DNA sequence data
81 Host Pathogen Interactions
84 Pathogenesis of chronic Pseudomonas aeruginosa infections
85 Unravelling mechanisms of host defence against Gram-positive pathogens in the mouse model
86 Microbial communication
87 Systems genetics of infection and immunity
88 The structural basis of mammalian prion transmission barriers
89 Biofi lm communities
90 Metabolic diversity