Research Report 2010 2011 - Helmholtz-Zentrum für ...
Research Report 2010 2011 - Helmholtz-Zentrum für ...
Research Report 2010 2011 - Helmholtz-Zentrum für ...
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SCIENTIFIC REPORTS | Publications<br />
167<br />
• Breitsprecher,D., Kiesewetter,A.K., Linkner,J., Vinzenz,M.,<br />
Stradal,T.E.*., Small,J.V., Curth,U., Dickinson,R.B., & Faix,J. (<strong>2011</strong>)<br />
Molecular mechanism of Ena/VASP-mediated actin-filament elongation.<br />
Embo Journal 30, 456-467.<br />
Former RG Systems and Synthetic Biology | Prof. Dr. Vitor<br />
Martins dos Santos<br />
• Fazzini,R.A., Preto,M.J., Quintas,A.C., Bielecka,A., Timmis,K.N.*.,<br />
& dos Santos,V.A.P.M.*. (<strong>2010</strong>) Consortia modulation of the stress<br />
response: proteomic analysis of single strain versus mixed culture.<br />
Environmental Microbiology 12, 2436-2449.<br />
• Koutinas,M., Kiparissides,A., Lam,M.-C., Silva-Rocha,R., de<br />
Lorenzo,V., dos Santos,V.A.P.M.*., Pistikopoulos,E.N., & Mantalaris,A.<br />
(<strong>2010</strong>) Combining genetic circuit and microbial growth kinetic models:<br />
A challenge for biological modelling. Computer Aided Chemical<br />
Engineering 28, 301-306.<br />
• Koutinas,M., Lam,M.C., Kiparissides,A., Silva-Rocha,R., Godinho,M.,<br />
Livingston,A.G., Pistikopoulos,E.N., de,L., V, Dos,S.V., & Mantalaris,A.<br />
(<strong>2010</strong>) The regulatory logic of m-xylene biodegradation by Pseudomonas<br />
putida mt-2 exposed by dynamic modelling of the principal<br />
node Ps/Pr of the TOL plasmid. Environmental Microbiology 12, 1705-<br />
1718.<br />
• Lam,C.M.C., Puchalka,J., Diez,M.S., & dos Santos,V.A.P.M.*. (<strong>2010</strong>)<br />
Exploring networks at the genome scale. European Biotechnology<br />
Science and Industry News 9, 40-42.<br />
Dept. of Microbial Natural Products – HIPS & RG Microbial<br />
Drugs – HZI | Prof. Dr. Rolf Müller<br />
• Arp,G., Bissett,A., Brinkmann,N., Cousin,S., de Beer,D., Friedl,T.,<br />
Mohr,K.I.*., Neu,T.R., Reimer,A., Shiraishi,F., Stackebrandt,E.,<br />
& Zippel,B. (<strong>2010</strong>) Tufa-forming biofilms of German karstwater<br />
streams: Microorganisms, exopolymers, hydrochemistry and calcification.<br />
Geological Society Stecial Publication 336, 83-118.<br />
• Binz,T.M., Maffioli,S.I., Sosio,M., Donadio,S., & Müller,R. (<strong>2010</strong>) Insights<br />
into an unusual nonribosomal peptide synthetase biosynthesis:<br />
identification and characterization of the GE81112 biosynthetic<br />
gene cluster. Journal of Biological Chemistry 285, 32710-32719.<br />
• Brodmann,T., Janssen,D., Sasse,F., Irschik,H., Jansen,R., Müller,R., &<br />
Kalesse,M. (<strong>2010</strong>) Isolation and synthesis of chivotriene, a chivosazole<br />
shunt product from Sorangium cellulosum. European Journal of<br />
Organic Chemistry 27, 5155-5159.<br />
• Bulow,L., Nickeleit,I., Girbig,A.K., Brodmann,T., Rentsch,A.,<br />
Eggert,U., Sasse,F., Steinmetz,H., Frank,R., Carlomagno,T.,<br />
Malek,N.P., & Kalesse,M. (<strong>2010</strong>) Synthesis and biological characterization<br />
of argyrin F. ChemMedChem 5, 832-836.<br />
• Buntin,K., Irschik,H., Weissman,K.J., Luxenburger,E., Blöcker,H., &<br />
Müller,R. (<strong>2010</strong>) Biosynthesis of thuggacins in myxobacteria: comparative<br />
cluster analysis reveals basis for natural product structural<br />
diversity. Chemistry and Biology 17, 342-356.<br />
• Buntin,K., Weissman,K.J., & Müller,R. (<strong>2010</strong>) An unusual thioesterase<br />
promotes isochromanone ring formation in ajudazol biosynthesis.<br />
ChemBioChem 11, 1137-1146.<br />
• Chai,Y., Pistorius,D., Ullrich,A., Weissman,K.J., Kazmaier,U., &<br />
Müller,R. (<strong>2010</strong>) Discovery of 23 natural tubulysins from Angiococcus<br />
disciformis An d48 and Cystobacter SBCb004. Chemistry and Biology<br />
17, 296-309.<br />
• Daum,M., Schnell,H.J., Herrmann,S., Gunther,A., Murillo,R.,<br />
Müller,R., Bisel,P., Muller,M., & Bechthold,A. (<strong>2010</strong>) Functions of<br />
genes and enzymes involved in phenalinolactone biosynthesis.<br />
ChemBioChem 11, 1383-1391.<br />
• Erol,O., Schaberle,T.F., Schmitz,A., Rachid,S., Gurgui,C., El,O.M.,<br />
Lohr,F., Kehraus,S., Piel,J., Müller,R., & Konig,G.M. (<strong>2010</strong>) Biosynthesis<br />
of the myxobacterial antibiotic corallopyronin A. ChemBioChem<br />
11, 1253-1265.<br />
• Garcia,R., Gerth,K., Stadler,M., Dogma,I.J., Jr., & Müller,R. (<strong>2010</strong>)<br />
Expanded phylogeny of myxobacteria and evidence for cultivation of<br />
the ‘unculturables’. Molecular Phylogenetics and Evolution 57, 878-<br />
887.<br />
• Irschik,H., Kopp,M., Weissman,K.J., Buntin,K., Piel,J., & Müller,R.<br />
(<strong>2010</strong>) Analysis of the sorangicin gene cluster reinforces the utility of<br />
a combined phylogenetic/retrobiosynthetic analysis for deciphering<br />
natural product assembly by trans-AT PKS. ChemBioChem 11, 1840-<br />
1849.<br />
• Khatri,Y., Hannemann,F., Ewen,K.M., Pistorius,D., Perlova,O.,<br />
Kagawa,N., Brachmann,A.O., Müller,R., & Bernhardt,R. (<strong>2010</strong>) The<br />
CYPome of Sorangium cellulosum So ce56 and identification of<br />
CYP109D1 as a new fatty acid hydroxylase. Chemistry and Biology 17,<br />
1295-1305.<br />
• Kunze,B., Reck,M., Dotsch,A., Lemme,A., Schummer,D., Irschik,H.,<br />
Steinmetz,H., & Wagner-Döbler,I. (<strong>2010</strong>) Damage of Streptococcus<br />
mutans biofilms by carolacton, a secondary metabolite from the<br />
myxobacterium Sorangium cellulosum. BMC Microbiology 10, 199.<br />
• Li,Y., Weissman,K.J., & Müller,R. (<strong>2010</strong>) Insights into multienzyme<br />
docking in hybrid PKS-NRPS megasynthetases revealed by heterologous<br />
expression and genetic engineering. ChemBioChem 11, 1069-<br />
1075.<br />
• Menche,D., Li,P., & Irschik,H. (<strong>2010</strong>) Design, synthesis and biological<br />
evaluation of simplified analogues of the RNA polymerase inhibitor<br />
etnangien. Bioorganic and Medicinal Chemistry Letters 20, 939-941.<br />
• Nawrath,T., Gerth,K., Müller,R., & Schulz,S. (<strong>2010</strong>) The biosynthesis<br />
of the aroma volatile 2-methyltetrahydrothiophen-3-one in the bacterium<br />
Chitinophaga Fx7914. ChemBioChem 11, 1914-1919.<br />
• Nawrath,T., Gerth,K., Müller,R., & Schulz,S. (<strong>2010</strong>) Volatile methyl<br />
esters of medium chain length from the bacterium Chitinophaga<br />
Fx7914. Chemistry and Biodiversity 7, 2228-2253.<br />
• Nicolas,L., Anderl,T., Sasse,F., Steinmetz,H., Jansen,R., Höfle,G.,<br />
Laschat,S., & Taylor,R.E. (<strong>2010</strong>) Gephyronic Acid, a Missing Link between<br />
Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I):<br />
Structural Revision and Stereochemical Assignment of Gephyronic<br />
Acid. Angewandte Chemie International Edition 50, 938-941.<br />
• Rachid,S., Revermann,O., Dauth,C., Kazmaier,U., & Müller,R. (<strong>2010</strong>)<br />
Characterization of a novel type of oxidative decarboxylase involved<br />
in the biosynthesis of the styryl moiety of chondrochloren from an<br />
acylated tyrosine. Journal of Biological Chemistry 285, 12482-12489.<br />
• Vilchez,R., Lemme,A., Ballhausen,B., Thiel,V., Schulz,S., Jansen,R.,<br />
Sztajer,H., & Wagner-Döbler,I. (<strong>2010</strong>) Streptococcus mutans inhibits<br />
Candida albicans hyphal formation by the fatty acid signaling molecule<br />
trans-2-decenoic acid (SDSF). ChemBioChem 11, 1552-1562.<br />
• Weissmann,K.J. & Müller,R. (<strong>2010</strong>) Myxobacterial secondary metabolites:<br />
Bioactivities and modes-of-action. Natural Product <strong>Report</strong>s 27,<br />
1276-1295.<br />
• Adhikary,T., Kaddatz,K., Finkernagel,F., Schonbauer,A., Meissner,W.,<br />
Scharfe,M., Jarek,M., Blöcker,H., Muller-Brusselbach,S., & Müller,R.<br />
(<strong>2011</strong>) Genomewide analyses define different modes of transcriptional<br />
regulation by peroxisome proliferator-activated receptor-beta/<br />
delta (PPARbeta/delta). PLoS ONE 6, e16344.<br />
• Capell,A., Liebscher,S., Fellerer,K., Brouwers,N., Willem,M.,<br />
Lammich,S., Gijselinck,I., Bittner,T., Carlson,A.M., Sasse,F., Kunze,B.,<br />
Steinmetz,H., Jansen,R., Dormann,D., Sleegers,K., Cruts,M., Herms,J.,<br />
Van,B.C., & Haass,C. (<strong>2011</strong>) Rescue of progranulin deficiency associated<br />
with frontotemporal lobar degeneration by alkalizing reagents<br />
and inhibition of vacuolar ATPase. Journal of Neuroscience 31, 1885-<br />
1894.