Research Report 2010 2011 - Helmholtz-Zentrum für ...

164 SCIENTIFIC REPORTS | Publications
• Knobloch,T., Harmrolfs,K., Taft,F., Thomaszewski,B., Sasse,F., &
Kirschning,A. (2011) Mutational biosynthesis of ansamitocin antibiotics:
A diversity-oriented approach to exploit biosynthetic flexibility.
ChemBioChem 13, 540-547.
• Omnus,D.J., Mehrtens,S., Ritter,B., Resch,K., Yamada,M., Frank,R.,
Nourbakhsh,M., & Reboll,M.R. (2011) JKTBP1 is involved in stabilization
and IRES-dependent translation of NRF mRNAs by binding to 5’
and 3’ untranslated regions. Journal of Molecular Biology 407, 492-
504.
• Wunderlich,K., Juozapaitis,M., Ranadheera,C., Kessler,U., Martin,A.,
Eisel,J., Beutling,U., Frank,R., & Schwemmle,M. (2011) Identification
of high-affinity PB1-derived peptides with enhanced affinity to the
PA protein of Influenza A virus polymerase. Antimicrobial Agents and
Chemotherapy 55, 696-702.
• Anderl,T., Nicolas,L., Munkemer,J., Baro,A., Sasse,F., Steinmetz,H.,
Jansen,R., Hofle,G., Taylor,R.E., & Laschat,S. (2011) Gephyronic acid,
a missing link between polyketide inhibitors of eukaryotic protein
synthesis (Part II): Total synthesis of gephyronic acid. Angewandte
Chemie International Edition, in press.
• Bremer,C.M., Sominskaya,I., Skrastina,D., Pumpens,P., Wahed,A.A.,
Beutling,U., Frank,R., Fritz,H.J., Hunsmann,G., Gerlich,W.H., &
Glebe,D. (2011) N-terminal myristoylation-dependent masking of
neutralizing epitopes in the preS1 attachment site of hepatitis B
virus. Journal of Hepatology, in press.
• Kraemer,S., Lue,H., Zernecke,A., Kapurniotu,A., Andreetto,E.,
Frank,R., Lennartz,B., Weber,C., & Bernhagen,J. (2011) MIF-chemokine
receptor interactions in atherogenesis are dependent on an
N-loop-based 2-site binding mechanism. FASEB Journal, in press.
• Maenz,B., Goetz,V., Wunderlich,K., Eisel,J., Kirchmair,J., Stech,J.,
Stech,O., Chase,G., Frank,R., & Schwemmle,M. (2011) Disruption of
the viral polymerase complex assembly as a novel approach to attenuate
influenza a virus. Journal of Biological Chemistry, in press.
• Ritter,B., Kilian,P., Reboll,M.R., Resch,K., Distefano,J.K., Frank,R.,
Beil,W., & Nourbakhsh,M. (2011) Differential effects of multiplicity
of infection on Helicobacter pylori-induced signaling pathways and
interleukin-8 gene transcription. Journal of Clinical Immunology, in
press.
• Schneider,J., Fricke,C., Overwin,H., & Hofer,B. (2011) High level
expression of a recombinant amylosucrase gene and selected properties
of the enzyme. Applied Microbiology and Biotechnology, in press.
• Westermann,J., Florcken,A., Willimsky,G., van,L.A., Kopp,J.,
Takvorian,A., Johrens,K., Lukowsky,A., Schonemann,C., Sawitzki,B.,
Pohla,H., Frank,R., Dorken,B., Schendel,D.J., Blankenstein,T., &
Pezzutto,A. (2011) Allogeneic gene-modified tumor cells (RCC-26/
IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer:
a clinical phase-I study. Gene Therapy, in press.
RG Biological Systems Analysis | Prof. Dr. Ursula Bilitewski
• Klippel,N., Cui,S., Groebe,L., & Bilitewski,U. (2010) Deletion of the
Candida albicans histidine kinase gene CHK1 improves recognition
by phagocytes through an increased exposure of cell wall beta-1,3-
glucans. Microbiology 156, 3432-3444.
Dept. of Medicinal Chemistry | Prof. Dr. Markus Kalesse
• Brodmann,T., Janssen,D., Sasse,F., Irschik,H., Jansen,R., Müller,R., &
Kalesse,M. (2010) Isolation and synthesis of chivotriene, a chivosazole
shunt product from Sorangium cellulosum. European Journal of
Organic Chemistry 27, 5155-5159.
• Brodmann,T., Janssen,D., & Kalesse,M. (2010) Total synthesis of
chivosazole F. Journal of the American Chemical Society 132, 13610-
13611.
• Bulow,L., Nickeleit,I., Girbig,A.K., Brodmann,T., Rentsch,A.,
Eggert,U., Sasse,F., Steinmetz,H., Frank,R., Carlomagno,T.,
Malek,N.P., & Kalesse,M. (2010) Synthesis and biological characterization
of argyrin F. ChemMedChem 5, 832-836.
• Kena,D.A., Noll,C., Richter,M., Gieseler,M.T., & Kalesse,M. (2010)
Intramolecular stereoselective protonation of aldehyde-derived enolates.
Angewandte Chemie International Edition 49, 8367-8369.
• Li,P., Li,J., Arikan,F.*., Ahlbrecht,W., Dieckmann,M., & Menche,D.
(2010) Stereoselective total synthesis of etnangien and etnangien
methyl ester. Journal of Organic Chemistry 75, 2429-2444.
• Menche,D., Li,P., & Irschik,H. (2010) Design, synthesis and biological
evaluation of simplified analogues of the RNA polymerase inhibitor
etnangien. Bioorganic and Medicinal Chemistry Letters 20, 939-941.
• Mohamed,I.E., Kehraus,S., Krick,A., Konig,G.M., Kelter,G., Maier,A.,
Fiebig,H.H., Kalesse,M., Malek,N.P., & Gross,H. (2010) Mode of action
of epoxyphomalins A and B and characterization of related metabolites
from the marine-derived fungus Paraconiothyrium sp. Journal of
Naturald Products 73, 2053-2056.
• Rand,K., Noll,C., Schiebel,H.M., Kemken,D., Dulcks,T., Kalesse,M.,
Heinz,D.W.*., & Layer,G. (2010) The oxygen-independent coproporphyrinogen
III oxidase HemN utilizes harderoporphyrinogen as a
reaction intermediate during conversion of coproporphyrinogen III to
protoporphyrinogen IX. Biological Chemistry 391, 55-63.
• Schackel,R., Hinkelmann,B., Sasse,F., & Kalesse,M. (2010) The synthesis
of novel disorazoles. Angewandte Chemie International Edition
49, 1619-1622.
• Stauch,B., Simon,B., Basile,T., Schneider,G., Malek,N.P., Kalesse,M., &
Carlomagno,T. (2010) Elucidation of the structure and intermolecular
interactions of a reversible cyclic-peptide inhibitor of the proteasome
by NMR spectroscopy and molecular modeling. Angewandte Chemie
International Edition 49, 3934-3938.
RG Environmental Microbiology | Prof. Dr. Ken N. Timmis
• Beloqui,A., Nechitaylo,T.Y., Lopez-Cortes,N., Ghazi,A.,
Guazzaroni,M.E., Polaina,J., Strittmatter,A.W., Reva,O., Waliczek,A.,
Yakimov,M.M., Golyshina,O.V., Ferrer,M., & Golyshin,P.N. (2010) Diversity
of glycosyl hydrolases from cellulose-depleting communities
enriched from casts of two earthworm species. Applied and Environmental
Microbiology 76, 5934-5946.
• Beloqui,A., Polaina,J., Vieites,J.M., Reyes-Duarte,D., Torres,R.,
Golyshina,O.V., Chernikova,T.N., Waliczek,A., Aharoni,A.,
Yakimov,M.M., Timmis,K.N.*., Golyshin,P.N., & Ferrer,M. (2010)
Novel hybrid esterase-haloacid dehalogenase enzyme. ChemBioChem
11, 1975-1978.
• Fazzini,R.A., Preto,M.J., Quintas,A.C., Bielecka,A., Timmis,K.N.*.,
& dos Santos,V.A.P.M.*. (2010) Consortia modulation of the stress
response: proteomic analysis of single strain versus mixed culture.
Environmental Microbiology 12, 2436-2449.
• Gertler,C., Näther,D.J., Gerdts,G., Malpass,M.C., & Golyshin,P.N.*.
(2010) A mesocosm study of the changes in marine flagellate and
ciliate communities in a crude oil bioremediation trial. Microbial
Ecology 60, 180-191.
• Martin-Arjol,I., Bassas-Galia,M.*., Bermudo,E., Garcia,F., &
Manresa,A. (2010) Identification of oxylipins with antifungal activity
by LC-MS/MS from the supernatant of Pseudomonas 42A2. Chemistry
and Physics of Lipids 163, 341-346.
• Nechitaylo,T.Y., Yakimov,M.M., Godinho,M., Timmis,K.N.*.,
Belogolova,E., Byzov,B.A., Kurakov,A.V., Jones,D.L., & Golyshin,P.N.
(2010) Effect of the earthworms Lumbricus terrestris and Aporrectodea
caliginosa on bacterial diversity in soil. Microbial Ecology 59,
574-587.