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egularity constraints on the underlying classes <strong>of</strong> an observed image, which allow<br />

Bayesian optimization <strong>of</strong> the classification. However, the computing time is <strong>of</strong>ten<br />

prohibitive with this approach. A substantially quicker alternative is to use a <strong>hidden</strong><br />

Markov model (HMM), which can be adapted to two-dimensional <strong>analysis</strong> through<br />

different types <strong>of</strong> scanning methods (e.g. Line Scan, Hilbert-Peano scan etc.). Markov<br />

random field <strong>models</strong> can only be used <strong>for</strong> small neighbourhoods in the image, due to the<br />

computational complexity and the modeling problems posed by large neighbourhoods<br />

(Aas et al., 1999). Leroux and Puterman (1992) used maximum–penalized likelihood<br />

estimation to estimate the independent and the Markov-dependent mixture model<br />

parameters. In their <strong>analysis</strong>, they focus on the use <strong>of</strong> Poisson mixture <strong>models</strong> assuming<br />

independent observations and Markov-dependent <strong>models</strong> (or <strong>hidden</strong> Markov Models)<br />

<strong>for</strong> a set <strong>of</strong> univariate fetal movement counts. Extending this idea, <strong>for</strong> a set <strong>of</strong><br />

<strong>multivariate</strong> Poisson counts, a novel <strong>multivariate</strong> Poisson <strong>hidden</strong> Markov model<br />

(Markov-dependent <strong>multivariate</strong> Poisson finite mixture model) is introduced. These<br />

counts can be considered as a stochastic process, generated by a Markov chain whose<br />

state sequence cannot be observed directly but which can be indirectly estimated<br />

through observations. Zhang et al. (2001) described that the finite mixture model is a<br />

degenerate version <strong>of</strong> the <strong>hidden</strong> Markov random field model. Fjφrt<strong>of</strong>t (2003) explained<br />

that the classification accuracy <strong>of</strong> <strong>hidden</strong> Markov random fields and <strong>hidden</strong> Markov<br />

<strong>models</strong> were not differing very much. Hidden Markov <strong>models</strong> are much faster than the<br />

ones based on the Markov random fields (Fjφrt<strong>of</strong>t et al., 2003). The advantage <strong>of</strong> <strong>hidden</strong><br />

Markov <strong>models</strong> compared to the Markov random field <strong>models</strong> is the ability to combine<br />

7

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