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terminology and guidelines for glaucoma ii - Kwaliteitskoepel

terminology and guidelines for glaucoma ii - Kwaliteitskoepel

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Precautions<br />

Direct-acting: Axial myopia, history of retinal detachment or rhegmatogenous retinal lesions.<br />

Indirect-acting: Should be used with extreme caution in patients with marked vagotonia, bronchial asthma, spastic<br />

gastrointestinal disturbances, peptic ulcer, pronounced bradycardia <strong>and</strong> hypotension, recent myocardial<br />

infarction, epilepsy <strong>and</strong> Parkinsonism. Priory history of retinal detachment or rhegmatogenous retinal<br />

lesions.<br />

General anesthesia with curarization.<br />

Major side effects<br />

Direct-acting: Systemic: Intestinal cramps, branchospasm.<br />

Ocular: Miosis, pseudomyopia (up to 8D), browache, retinal detachment, ciliary spasm, increased<br />

pupillary block.<br />

Indirect-acting: Systemic: Cardiac irregularities, intestinal cramps.<br />

Ocular: Stinging, burning, lacrimation, browache, pseudomyopia, retinal detachment, conjunctival<br />

thickening, increased pupillary block, iris cysts, cataract.<br />

Pregnancy <strong>and</strong> nursing mothers<br />

Direct-acting: Only to be used if the potential benefit justifies the potential risk to the fetus or the infant.<br />

Indirect-acting: Contraindicated<br />

Drug interactions<br />

Direct-acting: A competitive interaction on outflow with prostagl<strong>and</strong>ins is assumed, since contraction of the ciliary<br />

muscle reduces the uveoscleral space.<br />

Indirect-acting: Patients undergoing systemic anticholinesterase treatment should be warned of the possible additive<br />

effects of the indirect-acting parasympathomimetics. General anesthesia with muscle relaxants.<br />

Wash-out<br />

The time needed to completely lose their activity: Direct acting: 3 days<br />

Indirect acting: several weeks. Some are irreversible.<br />

Ch. 3 - 17 EGS

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