terminology and guidelines for glaucoma ii - Kwaliteitskoepel
terminology and guidelines for glaucoma ii - Kwaliteitskoepel
terminology and guidelines for glaucoma ii - Kwaliteitskoepel
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Precautions<br />
Direct-acting: Axial myopia, history of retinal detachment or rhegmatogenous retinal lesions.<br />
Indirect-acting: Should be used with extreme caution in patients with marked vagotonia, bronchial asthma, spastic<br />
gastrointestinal disturbances, peptic ulcer, pronounced bradycardia <strong>and</strong> hypotension, recent myocardial<br />
infarction, epilepsy <strong>and</strong> Parkinsonism. Priory history of retinal detachment or rhegmatogenous retinal<br />
lesions.<br />
General anesthesia with curarization.<br />
Major side effects<br />
Direct-acting: Systemic: Intestinal cramps, branchospasm.<br />
Ocular: Miosis, pseudomyopia (up to 8D), browache, retinal detachment, ciliary spasm, increased<br />
pupillary block.<br />
Indirect-acting: Systemic: Cardiac irregularities, intestinal cramps.<br />
Ocular: Stinging, burning, lacrimation, browache, pseudomyopia, retinal detachment, conjunctival<br />
thickening, increased pupillary block, iris cysts, cataract.<br />
Pregnancy <strong>and</strong> nursing mothers<br />
Direct-acting: Only to be used if the potential benefit justifies the potential risk to the fetus or the infant.<br />
Indirect-acting: Contraindicated<br />
Drug interactions<br />
Direct-acting: A competitive interaction on outflow with prostagl<strong>and</strong>ins is assumed, since contraction of the ciliary<br />
muscle reduces the uveoscleral space.<br />
Indirect-acting: Patients undergoing systemic anticholinesterase treatment should be warned of the possible additive<br />
effects of the indirect-acting parasympathomimetics. General anesthesia with muscle relaxants.<br />
Wash-out<br />
The time needed to completely lose their activity: Direct acting: 3 days<br />
Indirect acting: several weeks. Some are irreversible.<br />
Ch. 3 - 17 EGS