terminology and guidelines for glaucoma ii - Kwaliteitskoepel
terminology and guidelines for glaucoma ii - Kwaliteitskoepel
terminology and guidelines for glaucoma ii - Kwaliteitskoepel
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3.7 - ANTIMETABOLITES IN GLAUCOMA FILTERING SURGERY<br />
See also Ch. 3.6.3.1 <strong>and</strong> FC XIII<br />
Antimetabolites are used to reduce scarring at the site of trabeculectomy 131,153-158 . Healing <strong>and</strong> scarring are the main<br />
determinant of the long term intraocular pressure control after trabeculectomy 169-163 .<br />
Aim: - to prevent postoperative conjunctival scarring with resultant failure of filtration<br />
- to reach a low target pressure<br />
Increaded risk <strong>for</strong> scarring:<br />
Neovascular <strong>glaucoma</strong><br />
Previous failed <strong>glaucoma</strong> filtration surgery<br />
Previous cataract surgery (conjunctival incision)<br />
Aphakia (intracapsular surgery)<br />
Recent intraocular surgery (< 3 months)<br />
Inflammatory eye disease e.g. uveitis, ocular pemphigoid, Stevens-Johnson Syndrome,<br />
Afro-Caribbean / Hispanic race<br />
Young age<br />
Chronic topical medications<br />
Drugs used:<br />
5-Fluorouracil:<br />
Dose: 5 mg. It is available in 25 <strong>and</strong> 50 mg/ml concentrations. 50 mg/ml now by far the most commonly used.<br />
Administered intra- or post-operatively.<br />
Intraoperative use:<br />
Post-operative use<br />
Administrated intra operatively on a filter paper or a sponge<br />
25 or 50 mg/ml undiluted solution<br />
Time of exposure usually 5 minutes (shorter time has minimal effect with 5-FU)<br />
Rinse with approximately 20 ml of balanced salt solution<br />
Relative contraindication if epithelial problems present<br />
5 mg injections. 0.1ml of 50 mg/ml undiluted solution<br />
Small calibre needle (e.g. 30 G needle on insulin syringe)<br />
Adjacent to but not into bleb (pH 9)<br />
Multiple injections possible - some evidence that less than a total of 3 injections<br />
has a minimal impact on scarring<br />
Mitomycin C:<br />
Dose: 0,1-0,5 mg/ml. Available in different preparation; care must be taken in diluting it to the desired concentration.<br />
Administered intra- operatively, or postoperatively 165-170 .<br />
Intraoperative use:<br />
Concentration: 0.2 - 0.4 mg/ml<br />
Administered intraoperatively on a filter paper or a sponge <strong>for</strong> 2-5 minutes<br />
Avoid contact with cut edge of conjunctive flap<br />
After application rinse with approximately 20 ml of balanced salt solution<br />
Ch. 3 - 37 EGS