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terminology and guidelines for glaucoma ii - Kwaliteitskoepel

terminology and guidelines for glaucoma ii - Kwaliteitskoepel

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3.7 - ANTIMETABOLITES IN GLAUCOMA FILTERING SURGERY<br />

See also Ch. 3.6.3.1 <strong>and</strong> FC XIII<br />

Antimetabolites are used to reduce scarring at the site of trabeculectomy 131,153-158 . Healing <strong>and</strong> scarring are the main<br />

determinant of the long term intraocular pressure control after trabeculectomy 169-163 .<br />

Aim: - to prevent postoperative conjunctival scarring with resultant failure of filtration<br />

- to reach a low target pressure<br />

Increaded risk <strong>for</strong> scarring:<br />

Neovascular <strong>glaucoma</strong><br />

Previous failed <strong>glaucoma</strong> filtration surgery<br />

Previous cataract surgery (conjunctival incision)<br />

Aphakia (intracapsular surgery)<br />

Recent intraocular surgery (< 3 months)<br />

Inflammatory eye disease e.g. uveitis, ocular pemphigoid, Stevens-Johnson Syndrome,<br />

Afro-Caribbean / Hispanic race<br />

Young age<br />

Chronic topical medications<br />

Drugs used:<br />

5-Fluorouracil:<br />

Dose: 5 mg. It is available in 25 <strong>and</strong> 50 mg/ml concentrations. 50 mg/ml now by far the most commonly used.<br />

Administered intra- or post-operatively.<br />

Intraoperative use:<br />

Post-operative use<br />

Administrated intra operatively on a filter paper or a sponge<br />

25 or 50 mg/ml undiluted solution<br />

Time of exposure usually 5 minutes (shorter time has minimal effect with 5-FU)<br />

Rinse with approximately 20 ml of balanced salt solution<br />

Relative contraindication if epithelial problems present<br />

5 mg injections. 0.1ml of 50 mg/ml undiluted solution<br />

Small calibre needle (e.g. 30 G needle on insulin syringe)<br />

Adjacent to but not into bleb (pH 9)<br />

Multiple injections possible - some evidence that less than a total of 3 injections<br />

has a minimal impact on scarring<br />

Mitomycin C:<br />

Dose: 0,1-0,5 mg/ml. Available in different preparation; care must be taken in diluting it to the desired concentration.<br />

Administered intra- operatively, or postoperatively 165-170 .<br />

Intraoperative use:<br />

Concentration: 0.2 - 0.4 mg/ml<br />

Administered intraoperatively on a filter paper or a sponge <strong>for</strong> 2-5 minutes<br />

Avoid contact with cut edge of conjunctive flap<br />

After application rinse with approximately 20 ml of balanced salt solution<br />

Ch. 3 - 37 EGS

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