A-Textbook-of-Clinical-Pharmacology-and-Therapeutics-5th-edition
A-Textbook-of-Clinical-Pharmacology-and-Therapeutics-5th-edition
A-Textbook-of-Clinical-Pharmacology-and-Therapeutics-5th-edition
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454 INDEX<br />
carteolol 429<br />
carvedilol 214<br />
case-control studies, adverse drug reactions 65<br />
casp<strong>of</strong>ungin 343–4<br />
catechol O-methyltransferase inhibitors 125<br />
catecholamines, metabolism 27<br />
cavernosal injection, alprostadil 315<br />
CD4 receptor, HIV infection 351<br />
CD41 T-cells 400<br />
cefalexin, cystic fibrosis 34<br />
cefotaxime 327<br />
ceftazidime 327<br />
ceftriaxone 327<br />
cefuroxime 327<br />
celiprolol 214<br />
cell-based therapies 92–6<br />
cell cycle, phase specificity <strong>of</strong> cytotoxic drugs<br />
368, 369<br />
cellular immunity 399<br />
central nervous system<br />
elderly patients 58<br />
fetus 45<br />
central pontine myelinolysis 277<br />
cephalosporins 327<br />
cerebellar ataxia 129<br />
5-fluorouracil 376<br />
cetirizine 241, 405, 406<br />
cetuximab 383<br />
charcoal, activated 445, 446<br />
chelating agents, <strong>of</strong> metals 10<br />
chemokine receptors, HIV infection 351<br />
chemoreceptor trigger zone (CTZ) 253<br />
chemotherapy, malignant disease 367–85<br />
see also cytotoxic drugs<br />
children 52–5<br />
cycloplegia 425<br />
hypnotics 107<br />
iron preparations 390<br />
tetracyclines <strong>and</strong> 329<br />
chimeric antibodies 382<br />
chloral see cloral<br />
chlorambucil 372<br />
bone marrow suppression 370<br />
chloramphenicol 328<br />
aplastic anaemia 328, 395<br />
bacterial resistance 325<br />
eye 427<br />
2-chlorodeoxy adenosine 377<br />
chloroprocaine 154<br />
chloroquine<br />
acute malaria 362–3<br />
G6PD deficiency 366<br />
malaria prophylaxis 362<br />
rheumatoid arthritis 170<br />
chlorphenamine 405<br />
anaphylactic shock 405<br />
chlorpromazine 112–13<br />
hepatotoxicity 263<br />
chlorpropamide 289<br />
alcohol <strong>and</strong> 442<br />
elderly patients <strong>and</strong> 59<br />
chlortalidone 191, 192<br />
chlortetracycline, eye 427<br />
cholecalciferol 297<br />
cholecystokinin 263<br />
cholesterol 177–8<br />
diuretics 192<br />
see also familial hypercholesterolaemia<br />
cholestyramine see colestyramine<br />
cholinergic crisis 130–1<br />
cholinergic receptors, eye 424<br />
cholinesterase 25<br />
chondroitin 101<br />
chorea (Huntington’s disease) 129<br />
chorionic gonadotrophin 312<br />
chronic obstructive pulmonary disease 235–6<br />
-adrenoceptor antagonists 190<br />
glucocorticoids 236, 239<br />
chronic viral hepatitis 261<br />
chronotropes, negative 212<br />
ciclosporin 401–2<br />
azoles <strong>and</strong> 350, 402<br />
on casp<strong>of</strong>ungin 343<br />
glucocorticoid requirement reduction 241<br />
inflammatory bowel disease 256<br />
plasma concentration monitoring 43<br />
psoriasis 414<br />
seizures 408<br />
cid<strong>of</strong>ovir 347<br />
cilastatin 327<br />
ciliary body 423<br />
cimetidine 249–50, 251<br />
ciclosporin <strong>and</strong> 402<br />
theophylline <strong>and</strong> 239<br />
warfarin <strong>and</strong> 208, 252<br />
cinacalcet 300<br />
cinchonism 363<br />
cinnarizine 254<br />
cipr<strong>of</strong>loxacin 331<br />
for diarrhoea 259<br />
eye 427<br />
cirrhosis 274<br />
cisatracurium 151<br />
cisplatin 373–4<br />
methotrexate <strong>and</strong> 375<br />
citric acid 279<br />
cladribine 377<br />
clarithromycin 328, 329<br />
clearance <strong>of</strong> creatinine, nomogram 36<br />
clearance <strong>of</strong> drugs 11–12, 13, 31<br />
liver disease 38<br />
see also elimination <strong>of</strong> drugs<br />
clindamycin, Pneumocystis carinii 358<br />
clinical trials 5, 64, 86–8, 89–90<br />
cl<strong>of</strong>azimine 339<br />
cl<strong>of</strong>ibrate 182<br />
clomethiazole 109, 442<br />
clomifene 312<br />
clonazepam 137–8<br />
clonidine 150<br />
clopidogrel 209<br />
ischaemic heart disease 198, 199<br />
cloral (chloral) 109, 442<br />
Clostridium difficile 259<br />
clotrimazole 342<br />
clotting factors 92, 394–5<br />
clozapine 110, 113<br />
co-amoxiclav 326<br />
co-proxamol, overdose 448–9<br />
co-trimoxazole 330<br />
ganciclovir <strong>and</strong> 347<br />
Pneumocystis carinii 357<br />
teratogenesis 51<br />
coagulation cascade 204–5<br />
coagulation factors 92, 394–5<br />
cocaine 153, 438<br />
on fetus 50<br />
coccidioidomycosis<br />
drugs for 340<br />
HIV infection 359<br />
codeine 162, 242<br />
as antimotility drug 256, 258<br />
colchicine 172<br />
colestyramine 181, 182<br />
inflammatory bowel disease 256<br />
colfosceril palmitate 242<br />
collagens, glucosamine <strong>and</strong> 101<br />
colloid infusion 277<br />
combination therapy 72<br />
anti-emetic 370<br />
antibacterial 325<br />
with cytotoxic chemotherapy 371<br />
highly active antiretroviral therapy 352–3<br />
malignant disease 369<br />
nucleoside analogue reverse transcriptase<br />
inhibitors 353<br />
for Parkinson’s syndrome 125<br />
tuberculosis 72, 335–6, 338<br />
combined oral contraceptives 308–10, 311, 315<br />
common cold, echinacea <strong>and</strong> 99<br />
competitive antagonists 8, 9, 10<br />
on effect <strong>of</strong> partial agonists 9<br />
complementary medicines 97–102<br />
compliance<br />
antituberculous therapy 336<br />
elderly patients 58<br />
concentrations <strong>of</strong> drugs<br />
constant-rate infusion 11<br />
dissociation equilibrium constant 9<br />
monitoring 41–4<br />
in overdose 445<br />
paracetamol overdose 447<br />
repeated dosing 14<br />
vs response to drugs 6<br />
single-bolus dose 12<br />
confidence intervals 89<br />
confusion (mental), H 2 -receptor antagonists 251<br />
conjugation 24, 25–7<br />
Conn’s syndrome 305<br />
constant-rate infusion, pharmacokinetics 11–12<br />
constipation 256–8<br />
liver disease 38<br />
contact dermatitis 66–7, 413, 417<br />
contact lenses, drug-induced problems 429<br />
contraceptives (hormonal) 308–11<br />
anticonvulsants <strong>and</strong> 139<br />
antituberculous drugs <strong>and</strong> 339<br />
combined oral 308–10, 311, 315<br />
on fetus 50<br />
post-coital 310<br />
progestogens 308<br />
contrast media, X-rays, reactions 404<br />
controlled drugs 436–7<br />
controls, clinical trials 88<br />
copper 269<br />
coronary artery bypass grafting 197–8, 200<br />
coronary syndrome, acute 198, 199<br />
see also myocardial infarction<br />
corticosteroids<br />
children 54<br />
interaction with anticonvulsants 74<br />
occlusion on skin absorption 20, 22<br />
on phenylethanolamine N-methyltransferase<br />
27<br />
pregnancy 50<br />
see also glucocorticoids<br />
cough 242<br />
ACEIs 188<br />
asthma 55<br />
COX-2 inhibitors, selective 167, 169<br />
crack cocaine 438<br />
creatine phosphokinase, intramuscular injections<br />
<strong>and</strong> 21<br />
creatinine, serum levels<br />
elderly patients 57<br />
renal failure 36<br />
Crigler–Najjar syndrome 27<br />
criminal poisoning 449<br />
Crohn’s disease 255, 256<br />
drug disposition 34<br />
cromoglicate 405<br />
asthma 239–40<br />
eye 428<br />
hay fever 406<br />
cross-tolerance 433<br />
crossover design, clinical trials 88<br />
cryptococcosis 340, 359
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