A-Textbook-of-Clinical-Pharmacology-and-Therapeutics-5th-edition

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INDEX 457 5-fluorouracil 375–6 fluoxetine, monoamine oxidase inhibitors and 118 flutamide 384 fluticasone 240 folate 392 antagonism in malaria treatment 364 deficiency 268, 269, 392 Toxoplasma gondii 358 vitamin B 12 deficiency 391 see also antifolate analogues folinic acid methotrexate antagonism 374, 375 methotrexate concentrations requiring 42 follicle-stimulating hormone 307, 312, 317 fomiversen 95 fondaparinux 206 food drug absorption and 19 on first-pass metabolism 29 formularies 4 formulations of drugs bioequivalence 18, 90 elderly patients 60 see also liquid preparations fosamprenavir 356 foscarnet 346 cytomegalovirus 359 eye 427 fosphenytoin 136, 137 framycetin, eye 427 free-radical hypothesis, Parkinson’s syndrome 124 fulvestrant 312, 384 fungi 340 drugs against 340–4 HIV infection 359 skin infections 416 furosemide 275 methotrexate and 375 pulmonary oedema 213 fusidic acid 329 eye 427 on liver 262 fusion inhibitors (HIV) 357 G-protein-linked receptors 7 desensitization 9 G6PD deficiency see glucose 6-phosphate dehydrogenase deficiency GABA (-aminobutyric acid) 133 gabapentin 138 galantamine 131–2 gallstones drug-induced 69 octreotide 317 ganciclovir 346–7 cytomegalovirus infection 359 eye 427 garlic 97–8 gastrectomy partial, iron absorption 389 vitamin B 12 deficiency 391 gastric emptying see stomach, emptying gastric haemorrhage 252 aspirin 157 gastric lavage 445 gastric ulcers, endoscopy 249 gastrin 247 gastro-oesophageal reflux, pregnancy 49 gastrointestinal tract 247–59 bacteria drug absorption and 20 drug metabolism 29 ‘dialysis’ 446 diseases on drug disposition 34 drug metabolism 28, 29 iron preparations on 390 kidney disease on 35 pharmacokinetics 19–20 gate mechanisms, pain 155 Gaucher’s disease, biotechnology 92 gefitinib 381 gemcitabine 377 gemeprost 311 gemfibrozil 181, 182, 183 gemtuzumab 383 gene therapy 92, 94–5, 96 general anaesthetics 145–54 inhalational 145–8 intravenous 148–9 generalized seizures, drugs for 134 generic drugs 90 prescribing 17–18 genetic variations, first-pass metabolism 29 genistein 100 genital herpes, aciclovir 345 gentamicin 328 eye 427 methotrexate and 375 plasma concentration monitoring 42 geriatrics, polypharmacy (case) 5 germ-line gene therapy 94 GHB (-hydroxybutyric acid) 442 giant-cell arteritis, prednisolone 169 Giardia lamblia, drugs for 365 Gilbert’s disease 84 ginkgo biloba 99 ginseng 98–9 glargine insulin 286 glaucoma acetazolamide 274 from anticholinergic agents 238 drugs for 425–6 mydriatics and 425 osmotic diuretics 276 glibenclamide 289 elderly patients and 59 gliclazide 289 glitazones 289–90 globalization, drug development 91 glomerular filtration 31 ACEIs 188 children 53 estimated rate 57 heart failure 35 pregnancy 47 renal failure 36 thyroid disease 39 glomerulonephritis, immune-complex, penicillamine 171 glucagon 288 glucan, echinocandins on synthesis 343 glucocorticoids 169, 302–5 for allergic disease 405 as anti-emetics 255 asthma 239 chronic obstructive pulmonary disease 236, 239 dermatitis 413–14 eye 427 hay fever 406 idiopathic thrombocytopenic purpura 395 immunosuppression 400–1 inflammatory bowel disease 255 inhaled 234, 239 for malignant disease 384 requirement reduction 241 thyroid disease 39 see also corticosteroids; hydrocortisone; prednisolone glucosamine 101 glucose 6-phosphate dehydrogenase deficiency 68–9, 81, 83, 331, 366 glucuronidation 25–7 neonates 28 glutamate 133 glutathione 27, 260 glycerol suppositories 257 glyceryl trinitrate 196–7, 198, 200–1 glycoprotein IIb/IIIa, inhibitors 209 glycylxylidide 223 gold salts 170–1 gonadotrophin-releasing hormone 307 analogues 317–18, 384 gonadotrophins 307, 312, 317 Good Clinical Practice 87 goserelin 312, 317, 318, 384 gout 171–3 granulocyte colony-stimulating factor 394 grapefruit juice 408 Graves’ ophthalmopathy 295 grey baby syndrome, chloramphenicol 328 griseofulvin 344 on spermatozoa 46 growth hormone 316–17 recombinant 92, 316 gynaecomastia, cimetidine 250 H 1 -receptors 404 antagonists see antihistamines H 2 -receptor antagonists 249–51 elderly patients 60 pancreatic enzyme replacement and 250, 259 H 2 -receptors 404 H 3 -receptors 404 haematinics see folate; iron; vitamin B 12 haematopoietic growth factors 370, 379, 392–4 haemodynamics, nitrates 201 haemolytic anaemia adverse drug reactions 68–9 antibiotics 331 methaemoglobinaemia 83 haemolytic disease of the newborn 400 haemophilias 394–5 desmopressin 278, 395 haemorrhage gastric 252 aspirin 157 liver disease 260 oesophageal varices 261 half-life, drug concentration 12, 13 heparin 206 liver disease 38 repeated dosing and 14 two-compartment models 15 halibut liver oil 265–6 hallucinogens 437 halofantrine 363 haloperidol 112, 114 halothane 146, 147 haptens 400 hay fever 405, 406 heart anthracyclines on 377–8 see also entries beginning cardiac... heart failure 211–16 -adrenoceptor antagonists 190, 214 pharmacokinetics 34–5 Helicobacter pylori 247–8, 249 helminthic infections 364–6 heparins 205–6 pregnancy 50, 209 hepatic encephalopathy 260–2 hepatitis, viral 348–9 chronic 261 hepatitis B virus 261
458 INDEX hepatotoxicity 69, 262, 263 halothane 146, 147 non-steroidal anti-inflammatory drugs 169 rifampicin 336 see also paracetamol hepcidin 389 herbal medicines 97–102 heroin (diamorphine) 161, 434, 435, 442 herpes simplex virus infection aciclovir 345 HIV infection 359 skin 417 high-density lipoprotein (HDL) 179 highly active antiretroviral therapy (HAART) 352–3 hirsutism 412 hirudin 206–7 histamine 404–5 atracurium causing release 151 histone deacetylase inhibitors 382 histoplasmosis drugs for 340 HIV infection 359 historical aspects 86 opioids 159 history-taking 4 adverse drug reactions 63 HIV infection 351–60 tuberculosis 338, 359 see also anti-HIV drugs HMG CoA reductase inhibitors see statins hoarseness, inhaled glucocorticoids 239 Hoffmann elimination, atracurium 151 homeopathic medicines 97 hookworm, drugs for 365 hormone replacement therapy (HRT) 311–12, 315 progestogens in 308, 312 hormones for acne 411 for malignant disease 383–4 human normal immunoglobulin 407–8 humanization antibodies 382 recombinant proteins 93 humoral immunity 399 Huntington’s disease 129 hydatid disease, drugs for 365 hydralazine 194 nitrates with 214 slow acetylators 81, 82 hydration, skin 20 hydrocortisone 303–4 anaphylactic shock 405 asthma 239 G6PD deficiency and 83 respiratory failure 242 hydrolysis of drugs 25 -hydroxybutyric acid (GHB) 442 hydroxychloroquine, rheumatoid arthritis 170 hydroxyphenyl amines 260 5-hydroxytryptamine migraine 142 mood disorders and 116 syndrome 118 see also serotonin-only hypothesis 5-hydroxytryptamine 1 agonists, migraine 142–3 5-hydroxytryptamine 3 receptor antagonists 254 hydroxyurea 377 hyoscine 253 hypercalcaemia 299 diuretics 192 hyperkalaemia 278–9, 280 ACEIs 188 calcium chloride in 227 treatment of heart failure 213 hyperosmolar non-ketotic coma 288 hypersensitivity reactions 399–400 delayed 66–7, 400 glucocorticoids for 400 with histamine release 404–5 vaccine preparations 407 hypertension 185–95 alcoholism 440 diabetes mellitus 286 erythropoietin 396 pregnancy 50 see also antihypertensive drugs hypertensive crises, monoamine oxidase inhibitors 120, 123 hyperthermia, malignant 80, 83–4, 152 hyperthyroidism 292, 293–5 pharmacokinetics 38–9 hyperuricaemia 171–3 hypnotics 105–7, 108, 109 elderly patients 58, 107 hypocalcaemia 300 hypoglycaemia 288 -adrenoceptor antagonists 190, 214, 224 alcohol 442 hypogonadism, male 313 hypokalaemia 278 diuretics 192, 275 drug-induced 69 elderly patients 59 heart failure 213 liver disease 38, 40 hyponatraemia antidepressants 118, 122 SIADH 277 hypopituitarism, hypothyroidism in 293 hypotension ACEIs 213 poisoning 446 postural 57–8 streptokinase 202 hypothermia 220 hypothyroidism 293 pharmacokinetics 38–9 hypovolaemia 277–8 hypoxia, nitrous oxide 147 hypoxia-inducible factor-1 (HIF) 393 ibuprofen 158 idiopathic thrombocytopenic purpura 395 idiosyncratic drug reactions 62 idoxuridine, eye 427 ifosfamide 372 imatinib 380–1 imidazoles 341–2 imipenem 327 immune-complex glomerulonephritis, penicillamine 171 immune-complex reactions 66, 400 immune responses 399 mediators and blockers 404–6 immunoglobulins (therapeutic) 93, 407–8 immunopharmacology 399–408 immunostimulants 407 immunosuppressive drugs 399, 400–4 inflammatory bowel disease 256 myasthenia gravis 130 plasma concentration monitoring 43 rheumatoid arthritis 170 impotence see erectile dysfunction inclusion criteria, clinical trials 88 incontinence 279 indinavir 356 indometacin 169 on ductus arteriosus 46, 313 induction of enzymes 27–8, 76 anticonvulsants 137 infections alcoholism 440 bacterial, treatment algorithm 324 carbimazole 294 cytotoxic chemotherapy 371 diabetes mellitus 287 eye 427 immunosuppression 400 mycobacterial 334–9 opioid addiction 435 parasites 361–6 skin 416–17 streptococcal, streptokinase and 202 viral 344 hepatitis 261, 348–9 skin 417 see also anti-HIV drugs; antiviral agents; HIV infection see also antibiotics; fungi; urinary tract, infections infective endocarditis, prophylaxis with antibiotics 325 infertility cytotoxic drugs 371 drugs for 312 immunosuppressive drugs 400 inflammation 167 inflammatory bowel disease 255–6 infliximab Crohn’s disease 256 immune diseases 171, 404 psoriasis 415 influenza, antiviral agents for 348 infusion, pharmacokinetics 11–12 inhalational anaesthetics 145–8 inhalers asthma 234 children 54 drug absorption from 21 glucocorticoids 239 asthma 234 insulin via 288 salbutamol 237 inhibition, enzymes 28 inhibitors, receptors 7 injection site reactions, enfuvirtide 357 inotropes, positive 212 insomnia 105–7 insulin(s) 286–8 ‘designer’ 92–3, 286 elderly patients 59 physiology 285 intensive care, sedation 150 intensive monitoring, adverse drug reactions 65 interferon-alfa 2b 385 interferons 348–9 theophylline and 239 viral hepatitis 261 interleukin-2 384, 407 interleukin-11 394 international normalized ratio (INR) 207 paracetamol overdose 447 interstitial nephritis, drug-induced 69, 70, 168 interstitial pneumonitis, bleomycin 385 intra-ocular pressure 425 see also glaucoma intra-uterine devices 310 intracranial pressure halothane and 146 osmotic diuretics 276 intramuscular injection 21 intranuclear receptors 7 intrathecal route 22 baclofen 128 methotrexate 375 morphine 160 intravenous route 22 anaesthetics 148–9
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A Textbook of Clinical Pharmacology
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A Textbook of Clinical Pharmacology
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This fifth edition is dedicated to
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CONTENTS FOREWORD PREFACE ACKNOWLED
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PREFACE Clinical pharmacology is th
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PART I GENERAL PRINCIPLES
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CHAPTER 1 INTRODUCTION TO THERAPEUT
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SCIENTIFIC BASIS OF USE OF DRUGS IN
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AGONISTS 7 100 100 Effect (%) Effec
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SLOW PROCESSES 9 100 2 Dose ratio -
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CHAPTER 3 PHARMACOKINETICS ● Intr
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REPEATED (MULTIPLE) DOSING 13 In re
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NON-LINEAR (‘DOSE-DEPENDENT’) P
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CHAPTER 4 DRUG ABSORPTION AND ROUTE
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ROUTES OF ADMINISTRATION 19 ROUTES
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ROUTES OF ADMINISTRATION 21 Transde
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ROUTES OF ADMINISTRATION 23 FURTHER
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PHASE II METABOLISM (TRANSFERASE RE
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ENZYME INDUCTION 27 and lorazepam.
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METABOLISM OF DRUGS BY INTESTINAL O
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CHAPTER 6 RENAL EXCRETION OF DRUGS
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ACTIVE TUBULAR REABSORPTION 33 ACTI
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RENAL DISEASE 35 DISTRIBUTION Drug
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LIVER DISEASE 37 Detailed recommend
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THYROID DISEASE 39 DIGOXIN Myxoedem
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CHAPTER 8 THERAPEUTIC DRUG MONITORI
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DRUGS FOR WHICH THERAPEUTIC DRUG MO
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CHAPTER 9 DRUGS IN PREGNANCY ● In
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PHARMACOKINETICS IN PREGNANCY 47 va
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PRESCRIBING IN PREGNANCY 49 an anti
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PRESCRIBING IN PREGRANCY 51 Case hi
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BREAST-FEEDING 53 METABOLISM At bir
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RESEARCH 55 lifelong effects as a r
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PHARMACODYNAMIC CHANGES 57 DISTRIBU
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EFFECT OF DRUGS ON SOME MAJOR ORGAN
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RESEARCH 61 FURTHER READING Dhesi J
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ADVERSE DRUG REACTION MONITORING/SU
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ADVERSE DRUG REACTION MONITORING/SU
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PREVENTION OF ALLERGIC DRUG REACTIO
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EXAMPLES OF ALLERGIC AND OTHER ADVE
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CHAPTER 13 DRUG INTERACTIONS ● In
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HARMFUL INTERACTIONS 73 Response Re
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HARMFUL INTERACTIONS 75 Table 13.1:
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HARMFUL INTERACTIONS 77 Table 13.5:
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CHAPTER 14 PHARMACOGENETICS ● Int
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GENETIC INFLUENCES ON DRUG METABOLI
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INHERITED DISEASES THAT PREDISPOSE
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INHERITED DISEASES THAT PREDISPOSE
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CLINICAL TRIALS 87 • Discovery
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CLINICAL DRUG DEVELOPMENT 89 Too ma
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GLOBALIZATION 91 ETHICS COMMITTEES
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CELL-BASED AND RECOMBINANT DNA THER
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HUMAN STEM CELL THERAPY 95 duration
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CHAPTER 17 ALTERNATIVE MEDICINES: H
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SOY 99 A case report has suggested
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MISCELLANEOUS HERBS 101 including h
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PART II THE NERVOUS SYSTEM
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CHAPTER 18 HYPNOTICS AND ANXIOLYTIC
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ANXIETY 107 and daytime sleeping sh
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ANXIETY 109 Key points • Insomnia
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SCHIZOPHRENIA 111 Box 19.1: Dopamin
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SCHIZOPHRENIA 113 The Boston Collab
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BEHAVIOURAL EMERGENCIES 115 Oral me
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DEPRESSIVE ILLNESSES AND ANTIDEPRES
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DEPRESSIVE ILLNESSES AND ANTIDEPRES
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LITHIUM, TRYPTOPHAN AND ST JOHN’S
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SPECIAL GROUPS 123 Case history A 4
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PARKINSON’S SYNDROME AND ITS TREA
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PARKINSON’S SYNDROME AND ITS TREA
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MYASTHENIA GRAVIS 129 CHOREA The γ
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ALZHEIMER’S DISEASE 131 Cholinerg
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CHAPTER 22 ANTI-EPILEPTICS ● Intr
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GENERAL PRINCIPLES OF TREATMENT OF
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GENERAL PRINCIPLES OF TREATMENT OF
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WITHDRAWAL OF ANTI-EPILEPTIC DRUGS
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FEBRILE CONVULSIONS 141 Case histor
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DRUGS USED FOR MIGRAINE PROPHYLAXIS
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CHAPTER 24 ANAESTHETICS AND MUSCLE
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INHALATIONAL ANAESTHETICS 147 is th
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SUPPLEMENTARY DRUGS 149 • Respira
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MUSCLE RELAXANTS 151 NON-DEPOLARIZI
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LOCAL ANAESTHETICS 153 have also pr
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CHAPTER 25 ANALGESICS AND THE CONTR
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DRUGS USED TO TREAT MILD OR MODERAT
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OPIOIDS 159 Key points Drugs for mi
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OPIOIDS 161 increases, correlating
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MANAGEMENT OF POST-OPERATIVE PAIN 1
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PART III THE MUSCULOSKELETAL SYSTEM
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CHAPTER 26 ANTI-INFLAMMATORY DRUGS
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DISEASE-MODIFYING ANTIRHEUMATIC DRU
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HYPERURICAEMIA AND GOUT 171 • Sto
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HYPERURICAEMIA AND GOUT 173 Pharmac
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PART IV THE CARDIOVASCULAR SYSTEM
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CHAPTER 27 PREVENTION OF ATHEROMA:
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PREVENTION OF ATHEROMA 179 responsi
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DRUGS USED TO TREAT DYSLIPIDAEMIA 1
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DRUGS USED TO TREAT DYSLIPIDAEMIA 1
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CHAPTER 28 HYPERTENSION ● Introdu
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DRUGS USED TO TREAT HYPERTENSION 18
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OTHER ANTIHYPERTENSIVE DRUGS 193 Ke
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OTHER ANTIHYPERTENSIVE DRUGS 195 Ca
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MANAGEMENT OF STABLE ANGINA 197 Ass
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MANAGEMENT OF UNSTABLE CORONARY DIS
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DRUGS USED IN ISCHAEMIC HEART DISEA
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DRUGS USED IN ISCHAEMIC HEART DISEA
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ANTICOAGULANTS 205 Intrinsic pathwa
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ANTICOAGULANTS 207 that the pharmac
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ANTICOAGULANTS IN PREGNANCY AND PUE
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CHAPTER 31 HEART FAILURE ● Introd
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DRUGS FOR HEART FAILURE 213 The dru
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DRUGS FOR HEART FAILURE 215 therape
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CHAPTER 32 CARDIAC DYSRHYTHMIAS ●
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CARDIOPULMONARY RESUSCITATION AND C
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TREATMENT OF OTHER SPECIFIC DYSRHYT
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SELECTED ANTI-DYSRHYTHMIC DRUGS 223
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PART V THE RESPIRATORY SYSTEM
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CHAPTER 33 THERAPY OF ASTHMA, CHRON
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CHRONIC BRONCHITIS AND EMPHYSEMA 23
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DRUGS USED TO TREAT ASTHMA AND CHRO
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DRUGS USED TO TREAT ASTHMA AND CHRO
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RESPIRATORY FAILURE 241 use in asth
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DRUG-INDUCED PULMONARY DISEASE 243
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PART VI THE ALIMENTARY SYSTEM
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CHAPTER 34 ALIMENTARY SYSTEM AND LI
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PEPTIC ULCERATION 249 • With rega
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PEPTIC ULCERATION 251 Ranitidine ha
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ANTI-EMETICS 253 Vestibular stimula
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INFLAMMATORY BOWEL DISEASE 255 cort
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CONSTIPATION 257 • in hepatocellu
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PANCREATIC INSUFFICIENCY 259 Ciprof
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LIVER DISEASE 261 withdrawal), smal
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DRUGS THAT MODIFY APPETITE 263 Tabl
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CHAPTER 35 VITAMINS AND TRACE ELEME
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VITAMIN C(ASCORBIC ACID) 267 dinucl
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TRACE ELEMENTS 269 Table 35.1: Comm
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PART VII FLUIDS AND ELECTROLYTES
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CHAPTER 36 NEPHROLOGICAL AND RELATE
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DIURETICS 275 Key points Diuretics
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VOLUME DEPLETION 277 is sometimes c
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DRUGS THAT AFFECT THE BLADDER AND G
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DRUGS THAT AFFECT THE BLADDER AND G
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PART VIII THE ENDOCRINE SYSTEM
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CHAPTER 37 DIABETES MELLITUS ● In
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DRUGS USED TO TREAT DIABETES MELLIT
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ANTITHYROID DRUGS 293 deficiency. P
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SPECIAL SITUATIONS 295 fertility. I
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CHAPTER 39 CALCIUM METABOLISM ● I
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BISPHOSPHONATES 299 effective in li
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CINACALCET 301 Further reading Bloc
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ADRENAL CORTEX 303 Table 40.1: Acti
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ADRENAL MEDULLA 305 injection may b
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CHAPTER 41 REPRODUCTIVE ENDOCRINOLO
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FEMALE REPRODUCTIVE ENDOCRINOLOGY 3
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FEMALE REPRODUCTIVE ENDOCRINOLOGY 3
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MALE REPRODUCTIVE ENDOCRINOLOGY 313
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MALE REPRODUCTIVE ENDOCRINOLOGY 315
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ANTERIOR PITUITARY HARMONES AND REL
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POSTERIOR PITUITARY HARMONES 319 FU
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PART IX SELECTIVE TOXICITY
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CHAPTER 43 ANTIBACTERIAL DRUGS ●
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COMMONLY PRESCRIBED ANTIBACTERIAL D
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PRINCIPLES OF MANAGEMENT OF MYCOBAC
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FIRST-LINE DRUGS IN TUBERCULOSIS TH
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MYCOBACTERIUM LEPRAE INFECTION 339
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ANTIFUNGAL DRUG THERAPY 341 POLYENE
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ANTIFUNGAL DRUG THERAPY 343 therapy
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ANTIVIRAL DRUG THERAPY (EXCLUDING A
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ANTIVIRAL DRUG THERAPY (EXCLUDING A
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INTERFERONS AND ANTIVIRAL HEPATITIS
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CHAPTER 46 HIV AND AIDS ● Introdu
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ANTI-HIV DRUGS 353 Table 46.1: Exam
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ANTI-HIV DRUGS 355 NON-NUCLEOSIDE A
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OPPORTUNISTIC INFECTIONS IN HIV-1-S
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ANTI-HERPES VIRUS THERAPY 359 salva
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CHAPTER 47 MALARIA AND OTHER PARASI
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MALARIA 363 Pharmacokinetics Chloro
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HELMINTHIC INFECTION 365 Table 47.2
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CHAPTER 48 CANCER CHEMOTHERAPY ●
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COMMON COMPLICATIONS OF CANCER CHEM
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DRUGS USED IN CANCER CHEMOTHERAPY 3
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PART X HAEMATOLOGY
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CHAPTER 49 ANAEMIA AND OTHER HAEMAT
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HAEMATINICS - IRON, VITAMIN B 12 AN
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HAEMATOPOIETIC GROWTH FACTORS 393 S
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IDIOPATHIC THROMBOCYTOPENIC PURPURA
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PART XI IMMUNOPHARMACOLOGY
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CHAPTER 50 CLINICAL IMMUNOPHARMACOL
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IMMUNOSUPPRESSIVE AGENTS 401 Ag Ant
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IMMUNOSUPPRESSIVE AGENTS 403 Table
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CHEMICAL MEDIATORS OF THE IMMUNE RE
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Page 420 and 421: PART XII THE SKIN
Page 422 and 423: CHAPTER 51 DRUGS AND THE SKIN ● I
Page 424 and 425: DERMATITIS (ECZEMA) 413 Avoid preci
Page 426 and 427: PSORIASIS 415 Emollients Improving
Page 428 and 429: ADVERSE DRUG REACTIONS INVOLVING TH
Page 430 and 431: ADVERSE DRUG REACTIONS INVOLVING TH
Page 432 and 433: PART XIII THE EYE
Page 434 and 435: CHAPTER 52 DRUGS AND THE EYE ● In
Page 436 and 437: DRUGS USED TO CONSTRICT THE PUPIL A
Page 438 and 439: DRUGS USED TO TREAT INFLAMMATORY DI
Page 440 and 441: CONTACT LENS WEARERS 429 Table 52.6
Page 442 and 443: PART XIV CLINICAL TOXICOLOGY
Page 444 and 445: CHAPTER 53 DRUGS AND ALCOHOL ABUSE
Page 446 and 447: OPIOID/NARCOTIC ANALGESICS 435 Tabl
Page 448 and 449: DRUGS THAT ALTER PERCEPTION 437 whi
Page 450 and 451: CENTRAL DEPRESSANTS 439 Peak plasma
Page 452 and 453: CENTRAL DEPRESSANTS 441 Key points
Page 454 and 455: MISCELLANEOUS 443 FURTHER READING G
Page 456 and 457: INTENTIONAL SELF-POISONING 445 Tabl
Page 458 and 459: INTENTIONAL SELF-POISONING 447 Tabl
Page 460 and 461: CRIMINAL POISONING 449 Commission o
Page 462 and 463: INDEX Note: Page numbers in italics
Page 464 and 465: INDEX 453 atrial fibrillation 217,
Page 466 and 467: INDEX 455 Cushing’s syndrome 302
Page 470 and 471: INDEX 459 children 54 diazepam 108
Page 472 and 473: INDEX 461 non-steroidal anti-inflam
Page 474 and 475: INDEX 463 puberty (male), delay 314
Page 476: INDEX 465 tolerance 9, 433 benzodia
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