PDF catalog - Teknolab AS
PDF catalog - Teknolab AS
PDF catalog - Teknolab AS
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BIOANALYTICAL<br />
PRODUCTS FOR BIOANALYTICAL SAMPLE PREPARATION<br />
Solid Phase Extraction (SPE) Products<br />
Biotage manufactures a comprehensive range of solid phase extraction products. These include both EVOLUTE<br />
and ISOLUTE resin-(or polymer-) based and silica-based sorbents which have different but complementary<br />
extraction characteristics. The range includes sorbents offering a choice of non-polar, mixed-mode and ion<br />
exchange retention mechanisms for extraction of drugs and metabolites from biological fluids. Depending on<br />
the assay requirements, the SPE method can be tailored to deliver high recoveries of a range of acidic, basic<br />
and neutral drugs using a single generic method, or highly selective extraction of a single drug with a very clean<br />
extract that exhibits minimal ion suppression.<br />
EVOLUTE Sample Preparation Products<br />
EVOLUTE SPE columns and plates are ideal for extraction<br />
of drugs and metabolites from biological fluid samples.<br />
EVOLUTE sorbents have a uniquely modified surface<br />
structure that is water-wettable, to promote robust,<br />
reliable sample preparation. They also have an optimized<br />
pore structure that minimizes the retention of high<br />
molecular weight endogenous materials present in<br />
complex sample matrices. The result is cleaner extracts,<br />
compared to other leading polymer based SPE products.<br />
EVOLUTE ABN has a balanced combination of polar<br />
(hydrophilic) and non-polar (hydrophobic) interactions, which, combined with simple generic methodology,<br />
allows simultaneous extraction of acidic, basic and neutral analytes of wide ranging polarity.<br />
EVOLUTE CX is a mixed-mode sorbent combining a water-wettable surface with uniform coverage of sulfonic<br />
acid (SO 3<br />
- ) groups and optimum exchange capacity. Generic methodology allows greater than 85% recovery<br />
for a wide range of basic analytes, and matrix effects from phospholipids are minimised.<br />
See page 152 for more details and ordering information.<br />
See Appendix 1a of the QuickStart Guide (page 141-155) for the EVOLUTE ABN and CX generic methods.<br />
ISOLUTE ENV+<br />
ISOLUTE ENV+ SPE columns and plates are ideal for extraction of extremely polar compounds which are not<br />
retained on EVOLUTE ABN. The sorbent is suitable for extraction of polar acidic, basic and neutral drugs and<br />
metabolites from biological fluids.<br />
See page 34 for more details and ordering information.<br />
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