PDF catalog - Teknolab AS
PDF catalog - Teknolab AS
PDF catalog - Teknolab AS
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MIXED-MODE SORBENTS<br />
ISOLUTE HAX: Mixed-mode SPE for Acidic Drugs<br />
ISOLUTE HAX is a mixed-mode sorbent for acidic analytes. The combination of non-polar (C8) and strong<br />
anion exchange functionalities make ISOLUTE HAX ideal for the extraction of a wide range of acidic analytes.<br />
The generic method includes interference elution steps to remove interferences, providing a very clean extract<br />
for analysis.<br />
Selection of mixed-mode generic SPE sorbent by analyte class<br />
Drug/Analyte<br />
Class<br />
EVOLUTE CX<br />
ISOLUTE<br />
HAX<br />
ISOLUTE<br />
HCX<br />
ISOLUTE<br />
HCX-3<br />
ISOLUTE<br />
HCX-5<br />
ISOLUTE<br />
HCX-Q a<br />
Acidic<br />
✓<br />
Basic ✓ ✓ ✓ ✓<br />
Basic / lipophilic ✓ ✓<br />
Basic (pK > 11)<br />
Polybasic<br />
Quaternary amine<br />
✓<br />
✓<br />
✓<br />
aOptimum sorbent for basic drugs where it is difficult or impossible to eliminate positive charge(s) using pH.<br />
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