Program Book - Confex

TUESDAY
November 8, 2011
and Oncological Research, Oklahoma City; Granada, Spain,
OK, 6 Cincinnati Children’s Hospital Medical Center and the US
Department of Veterans Affairs Medical Center, Cincinnati,
OH, 7 Hanyang University Hospital for Rheumatic Diseases,
Clinical Research Center for Rheumatoid Arthritis (CRCRA),
Seoul, South Korea, 8 Department of Medicine, Keck School of
Medicine, University of Southern California, Los Angeles, CA,
9
Divisions of Genetics and Molecular Medicine and Immunology,
King’s College London, London, United Kingdom, 10 University
of Chicago, Chicago, IL, 11 Arthritis and Clinical Immunology
Research Program, Oklahoma Medical Research Foundation,
Oklahoma City, OK, 12 Oklahoma Medical Research Foundation
and Oklahoma University Health Sciences Center, Oklahoma
City, OK, 13 Division of Rheumatologyand Immunology, Medical
University of South Carolina, Charleston, SC, 14 Medical University
of SC, Charleston, SC, 15 Wake Forest University Health Sciences,
Winston-Salem, NC, 16 National Defense Medical Center, Taipei,
17
Seoul National University College of Medicine, Seoul, South
Korea, 18 7Center for Molecular and Human Genetics, The
Research Institute at Nationwide Children’s Hospital and The
Ohio State University, Columbus, OH, 19 UCLA David Geffen
School of Medicine, Los Angeles, CA, 20 University of California
Los Angeles, Los Angeles, CA
3:15 pm
2478. Determination of the Contribution of An IRF5-SLE Risk
Haplotype to IRF5 expression and Alternative Splicing Using
Next-Generation Sequencing
Rivka Stone 1 , Peicheng Du 2 , Di Feng 1 , Lars Ronnblom 3 , Maija-
Leena Eloranta 4 , Robert Donnelly 1 and Betsy Barnes 1 , 1 University
of Medicine and Dentistry of New Jersey, Newark, NJ, 2 New
Jersey Medical School, Newark, NJ, 3 Department of Medical
Sciences, Section of Rheumatology, Uppsala University, Uppsala,
Sweden, 4 Section of Rheumatology, Uppsala University, Uppsala,
Sweden
3:30 pm
2479. Lupus Nephritis Susceptibility Markers in PDGRFA-GSX2,
SLC5A11, ID4, and HAS2-SNTB1 Regions Identified From a
Meta-Analysis of Genome Wide Association Studies of Women
with Systemic Lupus Erythematosus
Sharon A. Chung 1 , Elizabeth E. Brown 2 , Adrienne H. Williams 3 ,
Tushar Bhangale 4 , Paula S. Ramos 3 , Julie T. Ziegler 3 , Barry I.
Freedman 3 , Robert P. Kimberly 2 , Timothy J. Vyse 5 , Peter K.
Gregersen 6 , Chaim O. Jacob 7 , Marta E. Alarcon-Riquelme 8 ,
Betty P. Tsao 9 , John B. Harley 10 , Timothy W. Behrens 4 , M. Petri 11 ,
M. Ilyas Kamboh 12 , F. Yesim Demirci 12 , Susan Manzi 13 , Lindsey
A. Criswell 1 , Kathy L. Moser 14 , Patrick M. Gaffney 14 , Robert
R. Graham4 and Carl D. Langefeld 3 , 1 University of California,
San Francisco, San Francisco, CA, 2 University of Alabama at
Birmingham, Birmingham, AL, 3 Wake Forest School of Medicine,
Winston-Salem, NC, 4 Genentech, Inc., South San Francisco, CA,
5
King’s College London, London, United Kingdom, 6 Feinstein
Institute for Medical Research, Manhasset, NY, 7 University
of Southern California, Los Angeles, CA, 8 Oklahoma Medical
Research Foundation, Center for Genomics and Oncological
Research Pfizer-University of Granada-Junta de Andalucia,
Oklahoma City, OK, 9 University of California, Los Angeles, Los
Angeles, CA, 10 Cincinnati Children’s Hospital Medical Center
and the US Department of Veterans Affairs Medical Center,
Cincinnati, OH, 11 Johns Hopkins University School of Medicine,
Baltimore, MD, 12 University of Pittsburgh, Pittsburgh, PA,
13
Allegheny Singer Research Institute, Pittsburgh, PA, 14 Oklahoma
Medical Research Foundation, Oklahoma City, OK
3:45 pm
2480. Association of STAT 4 , IRF5 and BLK Polymorphisms with
Severity and Outcome in Lupus Nephritis
Karin G. Eriksson 1 , Agneta Zickert 2 , Johanna K. Sandling 3 , Andreas
Jönsen 4 , Elisabet Svenungsson 2 , Lars Rönnblom 1 , Timothy W.
Behrens 5 , Robert R. Graham 5 , Ward Ortmann 5 , Ann-Christine
Syvänen 3 , Iva Gunnarsson2 and Gunnel Nordmark 6 , 1 Section
of Rheumatology, Uppsala University, Uppsala, Sweden,
2
Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden,
3
Molecular Medicine, Uppsala University, Uppsala, Sweden,
4
Section of Rheumatology, Lund University, Lund, Sweden,
5
Genentech Inc, South San Francisco, CA, 6 Department of
Medical Sciences, Section of Rheumatology, Uppsala University,
Uppsala, Sweden
W192b
Systemic Sclerosis Fibrosing Syndromes and Raynaud’s
– Clinical Aspects and Therapeutics III
Moderators: Tatiana S. Rodriguez-Reyna, MD; National Institute
of medical Sciences and Nutrition; Mexico City, Mexico
Ariane Herrick, MD; University of Manchester, Manchester
Academic Health Science Centre; Manchester, United Kingdom
2:30 pm
2481. Effect of Warfarin On Survival In Scleroderma-Associated
and Idiopathic Pulmonary Arterial Hypertension. A Bayesian
Approach to Evaluating Treatment In Uncommon Disease
Sindhu R. Johnson 1 , John T. Granton 2 , George A. Tomlinson 2 ,
Haddas Grosbein 3 , Thaolan Le 4 , Peter Lee 5 , M. Elizabeth Seary 3 ,
Gillian A. Hawker 6 and Brian M. Feldman 3 , 1 Toronto Western
Hospital, Toronto, ON, 2 University of Toronto, Toronto, ON,
3
The Hospital for Sick Children, Toronto, ON, 4 University Health
Network Pulmonary Hypertension Programme, Toronto, ON,
5
Mt. Sinai Hospital, Toronto, ON, 6 Women’s College Hospital,
Toronto, ON
2:45 pm
2482. Diffusion of Carbon Monoxide Predicts Survival in
Systemic Sclerosis Patients with Pulmonary Hypertension and
Interstitial Lung Disease
Benjamin E. Schreiber 1 , Chris Valerio 1 , Greg Keir 2 , Clive Handler 1 ,
Athol U. Wells 2 , Christopher P. Denton 3 and John G. Coghlan 1 ,
1
Royal Free Hospital, London, London, United Kingdom, 2 Royal
Brompton Hospital, United Kingdom, 3 UCL Medical School,
London, United Kingdom
3:00 pm
2483. Digital Ischemic Ulcers in Scleroderma Treated with Oral
Treprostinil Diethanolamine: A Randomized, Double-Blind,
Placebo-Controlled, Multicenter Study
James R. Seibold 1 , Fredrick M. Wigley 2 , Elena Schiopu 3 ,
Christopher D. Denton 4 , Richard M. Silver 5 , Virginia D.
Steen 6 , Thomas A. Medsger Jr. 7 , Maureen D. Mayes 8 , Soumya
Chatterjee 9 , Lorinda Chung 10 , Mary Ellen Csuka 11 , Dinesh
Khanna 3 , Tracy M. Frech 12 , Jerry A. Molitor 13 , Naomi F.
Rothfield 14 , Ariane L. Herrick 15 , Robert W. Simms 16 , Janet E.
Pope 17 , Kristan D. Rollins 18 , Carl Arneson 18 , Michael Wade 18 and
on behalf of DISTOL Investigators 19 , 1 Scleroderma Research
102
2011 Program Book