Program Book - Confex

ACR CLINICAL SYMPOSIUM
11:00 am - noon
W183a
Periodic Fevers with Aphthous Stomatitis, Pharyngitis,
and Adenitis P/C
Moderators: Sivia K. Lapidus, MD; Morritown Memorial
Hospital; Morristown, NJ
Kenneth N. Schikler, MD; University of Louisville School of
Medicine; Louisville, KY
11:00 am
Periodic Fevers with Aphthou Stomatitis, Pharyngitis, and
Adenitis: Syndrome: What It Is, What It Isn’t, and What Has
Been Learned
Karyl S. Barron, MD; National Institute of Allergy and Infectious
Diseases/NIH; Bethesda, MD
Upon completion of this session, participants should be able to:
• define the diagnostic criteria or periodic fevers with aphthous
stomatitis, pharyngitis, and adenitis syndrome
• recognize the differential of periodic fevers with aphthous
stomatitis, pharyngitis, and adenitis syndrome
• construct a diagnostic plan to evaluate children presenting
with signs and symptoms compatible with periodic fevers with
aphthous stomatitis, pharyngitis, and adenitis
• explain research related to immunologic phenomena
identified in patients with periodic fevers with aphthous
stomatitis, pharyngitis, and adenitis syndrome
ACR CLINICAL SYMPOSIUM
11:00 am - 12:30 pm
ACR PLENARY SESSION III – DISCOVERY
2011 c/r
11:00 am - 12:30 pm
W375b
Moderators: Carol A. Langford, MD, MHS; Cleveland Clinic;
Cleveland, OH
Richard A. Furie, MD; North Shore Long Island Jewish Health
System; New Hyde Park, NY
11:00 am
2427. JAK2 Mediates the Stimulatory Effects of Transforming
Growth Factor beta on Fibroblast Activation and Tissue Fibrosis
Clara Dees 1 , Michal Tomcik 2 , Katrin Palumbo 1 , Alfiya
Akhmetshina 3 , Angelika Horn 1 , Pawel Zerr 1 , Oliver Distler 4 , Georg
Schett 1 and Jorg HW Distler 1 , 1 Department of Internal Medicine
3 and Institute for Clinical Immunology, University of Erlangen-
Nuremberg, Erlangen, Germany, 2 Institute of Rheumatology,
Department of Clinical and Experimental Rheumatology, 1st
Faculty of Medicine, Charles University, Prague, Czech Republic,
3
Department of Internal Medicine III and Institute for Clinical
Immunology, University of Erlangen-Nuremberg, Erlangen,
Germany, 4 University Hospital Zurich, Zurich, Switzerland
11:15 am
2428. RNAi Mediated Silencing of the Autoantigen hnRNP-A2
Dcreases Inflammatory Arthritis by Inhibiting Activation of
Cells of the Mononuclear Phagocytic System
Sonja Herman 1 , Jessy Presumey 2 , Juergen Pfatschbacher 1 , Wim
B. Vandenberg 3 , Florence Apparailley 2 and Gunter Steiner 1 ,
1
Medical University of Vienna, Vienna, Austria, 2 Hôpital Saint
Eloi, Montpellier, France, 3 Radboud University Nijmegen Med
Center, Nijmegen, Netherlands
W375d
The Three Ps of Dermatologic and Autoimmune
Disease: Pyoderma, Panniculitis and Pemphigus/
Pemphigoid C P/C
Moderator: Shelly P. Kafka, MD; Mountain State Rheumatology;
Clarksburg, WV
11:00 am
Pyoderma Gangrenosum: An Overlap of Dermatologic and
Rheumatic Disease
Jeffrey P. Callen, MD; University of Louisville School Medicine;
Louisville, KY
11:25 am
Panniculitis: What Should a Rheumatologist Know
Lela A. Lee, MD; Denver Health Medical Center; Denver, CO
11:50 am
Pemphigus and the Pemphigoid Diseases
Victoria P. Werth, MD; University of Pennsylvania and
Philadelphia Veterans Affairs Medical Center; Philadelphia, PA
Upon completion of this session, participants should be able to:
• describe the pathophysiology and immunology associated
with pyoderma, panniculitis and pemphigus/pemphigoid
• recognize and formulate a differential diagnosis for these
three conditions
• identify new treatment strategies including the use of diseasemodifying
anti-rheumatic drugs and biological medications as
possible treatment options
11:30 am
2429. A Functional IRF5 Variant Predicts Prognosis in Patients
with Systemic Sclerosis
Roozbeh Sharif 1 , Maureen D. Mayes 1 , Filemon K. Tan 1 , Olga
Gorlova 2 , Laura K. Hummers 3 , Ami A. Shah 3 , Daniel E. Furst 4 ,
Dinesh Khanna 5 , Javier Martin 6 , Lara Bossini-Castillo 7 , Emilio B.
Gonzalez 8 , Hilda T. Draeger 9 , Jun Ying 10 , Sandeep K. Agarwal 1 ,
Frank C. Arnett 1 , Fredrick M. Wigley 3 and Shervin Assassi 1 ,
1
University of Texas Health Science Center at Houston, Houston,
TX, 2 University of Texas M.D. Anderson Cancer Center, Houston,
TX, 3 Johns Hopkins University, Baltimore, MD, 4 UCLA Medical
School, Los Angeles, CA, 5 University of Michigan, Ann Arbor, MI,
6
Instituto de Parasitologia y Biomedicina Lopez-Neyra (CSIC),
Granada, Spain, 7 Consejo Superior de Investigaciones Científicas
(CSIC), Armilla (Granada), Spain, 8 University of Texas Medical
Branch, Galveston, TX, 9 Univ of TX Health Sci Ctr, San Antonio,
TX, 10 University of Texas M. D. Anderson Cancer Center, Houston,
TX
11:45 am
2430. Feasibility, Safety and Clinical Effects of a Single
Intradermal Administration of Autologous Tolerising Dendritic
Cells Exposed to Citrullinated Peptides in Patients with
Rheumatoid Arthritis
Ranjeny Thomas, Shayna Street, Nishta Ramnoruth, Helen
Pahau, Soi Law, Marion Brunck, Claire Hyde, Brendan O’Sullivan,
Christelle Capini, Ai Tran, Jennifer Ng and Sanjoy Paul, Univ of
Queensland, Brisbane, Australia
2011 Program Book 91
TUESDAY
November 8, 2011