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Program Book - Confex

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ACR/ARHP Poster Session B<br />

1266. Evaluation of A Novel Homogeneous Mobility Shift Assay<br />

for the Measurement of Human Antibodies-to-Infliximab<br />

and Infliximab Levels in Patient Serum. Shui Long Wang,<br />

Linda Ohrmund, Scott Hauenstein, Jared Salbato, Rukmini<br />

Reddy, Patrick Monk, Steven Lockton, Nicholas Ling and<br />

Sharat Singh, Prometheus Laboratories, San Diego, CA<br />

1267. Tofacitinib Reduces Interferon-γ and Interleukin-17<br />

Production From CD4+ T Cells in Patients with Rheumatoid<br />

Arthritis. Satoshi Kubo, Kunihiro Yamaoka, Koshiro<br />

Sonomoto, Keisuke Maeshima, Shintaro Hirata, Kazuhisa<br />

Nakano, Norifumi Sawamukai, Masao Nawata, Shigeru<br />

Iwata, Kazuyoshi Saito and Yoshiya Tanaka, University of<br />

Occupational and Environmental Health, Japan, Kitakyushu,<br />

Japan<br />

1268. A Phase 1, Randomized, Double-Blind, Placebo-<br />

Controlled, Multiple, Intravenous, Ascending-Dose Study<br />

of Sirukumab in Patients with Cutaneous or Systemic<br />

Lupus Erythematosus. Jacek C. Szepietowski 1 , Surasak<br />

Nilganuwong 2 , Anna Wozniacka 3 , Annegret Kuhn 4 , Filippa<br />

Nyberg 5 , Jacek Szechinski 1 , Ronald F. van Vollenhoven 6 ,<br />

Anders Bengtsson 7 , Adam Reich 1 , Dick de Vries 8 , Bart van<br />

Hartingsveldt 8 , Bei Zhou 9 and Benjamin Hsu 10 , 1 Wroclaw<br />

Medical University, Wroclaw, Poland, 2 Siriraj Hospital,<br />

Bangkok, Thailand, 3 Medical University of Lodz, Lodz,<br />

Poland, 4 University of Münster, Münster, Germany,<br />

5<br />

Karolinska Institutet, Danderyd Hospital, Stockholm,<br />

Sweden, 6 Karolinska Institute, Stockholm, Sweden,<br />

7<br />

Department of Rheumatology, Lund University Hospital,<br />

Sweden, 8 Janssen Biologics B.V., Leiden, Netherlands,<br />

9<br />

Centocor Research & Development, a Division of Johnson<br />

& Johnson Pharmaceutical Research & Development,<br />

LLC, Malvern, PA, 10 Centocor R&D, a division of J&J<br />

Pharmaceutical R& D, LLC/Univ. of Pennsylvania, Malvern/<br />

Philadelphia, PA<br />

1269. Meta-Analysis Suggests Intensive Non-Biologic<br />

Combination Therapy with Step-Down Prednisolone<br />

May Also ‘Disconnect’ Disease Activity and Damage in<br />

Rheumatoid Arthritis. Maarten Boers 1 , Lilian H.D. van Tuyl 1 ,<br />

Marianne van den Broek 2 , Piet J. Kostense 1 and Cornelia<br />

F. Allaart 2 , 1 VU University Medical Center, Amsterdam,<br />

Netherlands, 2 Leiden University Medical Center, Leiden,<br />

Netherlands<br />

1270. Clinical Response and B Cell Analysis by High-Sensitive<br />

Flowcytometry After the Second Course of Rituximab.<br />

Hans-Peter Brezinschek 1 , Franz Rainer 2 , Kerstin Brickmann 1 ,<br />

Raimund Lunzer 2 and Winfried B. Graninger 1 , 1 Medical<br />

University Graz, Graz, Austria, 2 Hospital Barmherzige<br />

Brueder, Graz- Eggenberg, Austria<br />

1271. Comparison of Tocilizumab and TNF Inhibitor Therapy in<br />

Rheumatoid Arthritis. Jörg Kaufmann 1 , Susanne Seel 2 and<br />

Anne-Eve Roske 3 , 1 Rheumatologist, Ludwigsfelde, Germany,<br />

2<br />

Ambulant Centres f. Rheumatology, Ludwigsfelde, Germany,<br />

3<br />

Roche Pharma AG, Grenzach-Wyhlen, Germany<br />

1272. Efficacy Evaluation of Tocilizumab with the New ACR/<br />

EULAR Remission Criteria and DAS28-ESR. Tomonori Ishii 1 ,<br />

Yasuhiko Hirabayashi 2 and Michinoku Tocilizumab Study<br />

Group 3 , 1 Department of Hematology and Rheumatology,<br />

Tohoku University Graduate School of Medicine, Sendai,<br />

Japan, 2 Hikarigaoka Spellman Hospital, Sendai, Japan,<br />

3<br />

Senndai<br />

1273. High Levels of Serum IL-6 but Not CRP or TNF-α During<br />

Tocilizumab Treatment Induces Myalgia Among the<br />

Patients with Rheumatoid Arthritis. Osamu Saiki 1 and<br />

Hiroshi Uda 2 , 1 Shiraishi Hospital, Imabari, Japan, 2 Keiseikai<br />

Hospital, Higashiosaka, Japan<br />

1274. Development of a Novel Recombinant Biotherapeutic<br />

with Applications in Targeted Therapy of Human Arthritis.<br />

Panagiotis Kamperidis 1 , Tahereh Kamalati 1 , Mathieu<br />

Ferrari 1 , Lewis Lee 1 , Rita Jones 1 , Toby Garrood 1 , Malcolm<br />

D. Smith 2 , Soraya Diez-Posada 1 , Chris Hughes 1 , Ciara<br />

Finucane 1 , Stephen Mather 1 , Ahuva Nissim 1 , Andrew J. T.<br />

George 1 and Costantino Pitzalis 3 , 1 London, United Kingdom,<br />

2<br />

Adelaide, Australia, 3 Centre for Experimental Medicine and<br />

Rheumatology, QMUL, London, United Kingdom<br />

1275. Gene Expression Profiling of Folate Pathway Related<br />

Genes in Methotrexate naïve- and Methotrexate-Treated<br />

Rheumatoid Arthritis Patients. Marjolein Blits 1 , Gerrit<br />

Jansen 1 , Yehuda G. Assaraf 2 and Cornelis L. Verweij 1 , 1 VU<br />

University Medical Center, Amsterdam, Netherlands,<br />

2<br />

Technion, Haifa, Israel<br />

1276. Retrospective Analysis of the Efficacy of Tacrolimus in<br />

Rheumatoid Arthritis: Suggestive Synergistic Effects with<br />

Methotrexate. Kenta Hoshi, Sumiaki Tanaka, Tatsuhiko<br />

Wada, Junichi Tanaka, Tatsuo Nagai and Shunsei Hirohata,<br />

Kitasato University School of Medicine, Sagamihara, Japan<br />

1277. Anti-CCP Titers Are Predictive of the Response to<br />

Biological Agents in Patients with Rheumatoid Arthritis.<br />

Ryo Takahashi 1 , Ryo Yanai 1 , Hidekazu Furuya 1 , Kuninobu<br />

Wakabayashi 1 , Tsuyoshi Odai 1 , Takeo Isozaki 2 , Nobuyuki<br />

Yajima 1 , Yusuke Miwa 3 and Tsuyoshi Kasama 1 , 1 Showa<br />

University School of Med, Shinagawa-ku Tokyo, Japan,<br />

2<br />

University of Michigan Medical School, Ann Arbor, MI,<br />

3<br />

Division of Rheumatology, Tokto, Japan<br />

1278. Abatacept Reduces N-Terminal Pro Brain Natriuretic<br />

Peptide Levels in Patients with Rheumatoid Arthritis:<br />

Results From a Prospective Cohort Study. Inge A.M. van<br />

den Oever 1 and Michael T. Nurmohamed 2 , 1 Jan van Breemen<br />

Research Institute Reade, Amsterdam, Netherlands, 2 Reade,<br />

Centre for Rehabilitation and Rheumatology, Amsterdam,<br />

Netherlands<br />

1279. Do Impared Memory, Cognitive Dysfonction and Distress<br />

Play a Role In Methotrexate-Related Pancytopenia In<br />

Rheumatoid Arthritis Patients Salim Donmez 1 , Yavuz<br />

Pehlivan 2 , Omer Nuri Pamuk 1 , Bunyamin Kisacik 2 , Gulsum<br />

Emel Pamuk 1 , Ahmet Mesut Onat 2 , Mehmet Sayarlioglu 3 and<br />

Gözde Yildirim Çetin 3 , 1 Edirne, Turkey, 2 Gaziantep, Turkey,<br />

3<br />

Kahramanmaras, Turkey<br />

226<br />

2011 <strong>Program</strong> <strong>Book</strong>

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