Program Book - Confex

ACR Poster Session A
37. Regulation of Synoviocyte Migration by phosphoinositide
3 Kinase (PI3K) Delta. Beatrix Bartok 1 , Deepa Hammaker 2 ,
Christian Rommel 3 and Gary S. Firestein 4 , 1 UCSD, La Jolla, CA,
2
Univ of California San Diego, La Jolla, CA, 3 Intellikine, Inc.,
La Jolla, CA, 4 UCSD School of Medicine, La Jolla, CA
38. Soluble Junctional Adhesion Molecule-B Inhibits
Angiogenesis in Rheumatoid Arthritis. Bradley J. Rabquer 1 ,
Beatrix Balogh 1 , Jeffrey H. Ruth 1 , Beat A. Imhof 2 and Alisa E.
Koch 3 , 1 University of Michigan, Ann Arbor, MI, 2 University of
Geneva, Switzerland, 3 Department of Veteran’s Affairs and
Unversity of Michigan, Ann Arbor, MI
39. FAAH Inhibition Reverses Glucocorticoid Effects in
Synovial Fibroblasts of Patients with Osteoarthritis and
Rheumatoid Arthritis. Torsten Lowin 1 , Elena Neumann 2 ,
Ulf Muller-Ladner 3 and Rainer H. Straub 1 , 1 University
Hospital Regensburg, Regensburg, Germany, 2 Justus-Liebig-
University of Gießen, Bad Nauheim, Germany, 3 Justus-Liebig
Universität Gießen, Kerckhoff-Klinik GmbH, Bad Nauheim,
Germany
40. Design of Peptides From CD2 to Modulate Protein-Protein
Interactions and Immune Response. Ameya Gokhale 1 ,
Veena Taneja 2 and Seetharama Satyanarayanajois 1 ,
1
University of Louisiana at Monroe, Monroe, LA, 2 Mayo
Clinic, Rochester, MN
41. Toll-Like Receptor 2 Induced Cell Migration and Invasion
Is Mediated Through ß1-Integrin Signalling Pathways and
Cytoskeletal Dynamics. Trudy McGarry 1 , Mary Connolly 2 ,
Jennifer McCormick 1 , Douglas J. Veale 1 and Ursula Fearon 1 ,
1
Dublin Academic Medical Centre, University College Dublin,
Dublin, Ireland, 2 Center of Experimental Rheumatology,
University Hospital Zürich, Zurich, Switzerland
Cytokines, Mediators, and Gene Regulation
42. Epigenetically Regulated MicroRNA-126 Influences
Migratory Potential and Apoptosis of Synovial Fibroblasts
in Rheumatoid Arthritis. Mojca Frank 1 , Maria Filkova 1 ,
Joanna Stanczyk 1 , Mary Connolly 1 , Christoph Kolling 2 , Beat
A. Michel 1 , Blaz Rozman 3 , Renate E. Gay 1 , Steffen Gay 1 and
Astrid Jungel 1 , 1 Center of Experimental Rheumatology,
University Hospital Zurich, Zurich, Switzerland, 2 Schultess
Clinic, Zurich, Switzerland, 3 University Medical Centre,
Ljubljana, Slovenia
43. Mathematical Modeling of Interleukin-6 Signaling
Inhibition: Comparative Efficiency of Different Intervention
Strategies. Saroja Ramanujan 1 , Daniel Young 1 , Peter
Maisonpierre 1 , Stevan Shaw 2 , Jason Chan 1 and Kosmas
Kretsos 2 , 1 Entelos, Inc., Foster City, CA, 2 UCB, Slough, United
Kingdom
44. Abnormalities in a JAK-STAT Pathway Are Involved in the
Aberrant Production of IL-6 by BAFF-Stimulated Peripheral
Monocytes of Patients with Primary Sjögren’s Syndrome.
Keiko Yoshimoto 1 , Maiko Tanaka 1 , Masako Kojuma 1 , Hideko
Ogata 1 , Hideto Kameda 1 , Tohru Abe 2 and Tsutomu Takeuchi 1 ,
1
Keio University School of Medicine, Tokyo, Japan, 2 Saitama
Medical School, Kawagoe-shi Saitama, Japan
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2011 Program Book
45. MiR-451 in Microparticles Derived From Monocytes
Influences Gene Expression in Rheumatoid Arthritis
Synovial Fibroblasts. Meike Dahlhaus 1 , Joanna Stanczyk 1 ,
Mojca Frank 1 , Beat A. Michel 1 , Christoph Kolling 2 , David S.
Pisetsky 3 , Renate E. Gay 1 , Steffen Gay 1 , Astrid Jüngel 1 and
Diego Kyburz 1 , 1 Center of Experimental Rheumatology,
University Hospital Zurich, Zurich, Switzerland, 2 Schultess
Clinic, Zurich, Switzerland, 3 Duke University Medical Center,
Durham, NC
46. The Influence of Cigarette Smoke on Expression of Histone
Deacetylases in Rheumatoid Arthritis. Anna Loeffler 1 , Peter
Kunzler 1 , Fabienne Niederer 1 , Astrid Jungel 1 , Christoph
Kolling 2 , Giovanni Camici 3 , Beat A. Michel 4 , Renate E. Gay 1 ,
Steffen Gay 1 and Caroline Ospelt 1 , 1 Center of Experimental
Rheumatology, University Hospital Zurich, Zurich,
Switzerland, 2 Schultess Clinic, Zurich, Switzerland, 3 Institute
of Physiology, University of Zurich, Switzerland, 4 University
Hospital, Zurich, Switzerland
47. A-SAA Induced Angiogenesis and Endothelial Cell Invasion
Is Mediated Through NOTCH Signalling Pathways. Peter
Rooney 1 , Mary Connolly 2 , Wei Gao 3 , Douglas J. Veale 4 and
Ursula Fearon 4 , 1 University College Dublin, Dublin, Ireland,
2
Center of Experimental Rheumatology, University Hospital
Zürich, Zurich, Switzerland, 3 St. Vincent’s University Hospital,
Dublin, Ireland, 4 Dublin Academic Medical Centre, University
College Dublin, Dublin, Ireland
48. Age-Related Mitochondrial Dysfunction Sensitizes Human
Synoviocytes to Inflammatory Response. M. Noa Valcárcel-
Ares 1 , Romina R. Riveiro-Naveira 1 , Carlos Vaamonde-García 1 ,
Laura Hermida-Carballo 1 , Francisco J. Blanco 2 and Maria
J. López-Armada 1 , 1 Aging and Inflammation Research Lab,
INIBIC-CHU A Coruña, A Coruña, Spain, 2 Osteoarticular and
Aging Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain
49. Regulatory and Anti-Inflammatory Effects of MAP Kinase
Phosphatase-1 in Inflammation and Arthritis. Riku
Korhonen 1 , Riina Nieminen 1 , Tuija Turpeinen 1 , Ville Taimi 1 ,
Antonis Goulas 2 , Andrew R. Clark 3 and Eeva Moilanen 1 ,
1
University of Tampere School of Medicine and Tampere
University Hospital, Tampere, Finland, 2 Aristotle University
of Thessaloniki, Greece, 3 Imperial College London, London,
United Kingdom
50. Critical Role for the IL-23/TNF Axis During TLR2/NOD2
Mediated Acute Joint Inflammation. Ferry Cornelissen 1 ,
Odilia B.J. Corneth 2 , Anne-Marie Mus 1 , Patrick S.
Asmawidjaja 1 and Erik Lubberts 1 , 1 Erasmus MC, University
Medical Center, Rotterdam, Netherlands, 2 Erasmus
MC, University Medical Center, Rotterdam, Rotterdam,
Netherlands
51. T-Cell-Related Cytokines Are Inhibited in Response to
Tocilizumab in Patients with Rheumatoid Arthritis in
Contrast with TNF-Inhibitor. Jiro Yamana 1 , Mitsuyoshi
Iwahashi 2 , Motoaki Kim 1 , Rie Sasaki 1 , Keisuke Kobayashi 1 ,
Seizo Yamana 1 , Yusuke Sasaki 3 , Yasushi Shimonaka 3 and
Masahiko Mihara 4 , 1 Higashi-hiroshima memorial Hospital,
Hiroshima, Japan, 2 Higashi-Hiroshima Memorial Hospital,