Program Book - Confex

3:30 pm
1639. Inflammatory Arthritis in Mice Is Dependent on the
Mast Cell-Restricted Signaling Protein Ras Guanine Nucleotide
Exchange Protein 4 (RasGRP4)
Richard Stevens 1 , Roberto Adachi 2 , Peter A. Nigrovic 3 , Matthew
J. Hamilton 3 and Steven Krilis 4 , 1 Brigham and Women’s Hospital,
Harvard Medical School, Boston, MA, 2 University of Texas M. D.
Anderson Cancer Center, Houston, TX, 3 Brigham and Women’s
Hospital, Boston, MA, 4 St George Hospital, Kogarah NSW,
Australia
3:45 pm
1640. The CYLD / IKKbeta Axis Functions in Synovial Fibroblasts
to Regulate TNF-Driven Arthritis
Maria Armaka 1 , Manolis Pasparakis 2 , George Mosialos 3
and George Kollias 1 , 1 Biomedical Sciences Research Center
‘Alexander Fleming’, Vari, Greece, 2 Institute for Genetics,
Centre for Molecular Medicine, University of Cologne, Cologne,
Germany, 3 School of Biology, Aristotle University of Thessaloniki,
Thessaloniki, Greece and Biomedical Sciences Research Center
‘Alexander Fleming’, Vari, Greece
W375c
Rheumatoid Arthritis Treatment – Small Molecules,
Biologics, Therapy: Existing Biologics
Moderators: Joan M. Bathon, MD; Columbia University Medical
Center; New York, NY
Peter M. Villiger, MD; Inselspital-University Hospital; Bern,
Switzerland
2:30 pm
1641. Low Serum IgG Level After Rituximab Is Associated with
An Increased Risk of Serious Infections in Rheumatoid Arthritis:
Data of the AIR Registry
Jacques-Eric Gottenberg 1 , Philippe Ravaud 2 , Thomas Bardin 3 ,
Patrice Cacoub 4 , Alain G. Cantagrel 5 , Bernard G. Combe 6 , Maxime
Dougados 7 , Rene-Marc Flipo 8 , Bertrand Godeau 9 , Loic Guillevin 10 ,
Xavier X. Le Loet 11 , Eric Hachulla 12 , Thierry Schaeverbeke 13 , Jean
Sibilia 14 , Isabelle Pane 15 , Adelina Abbe 15 , Gabriel Baron 16 and
Xavier Mariette 17 , 1strasbourg University Hospital, Strasbourg,
France, 2 Hotel Dieu University hospital, France, 3 Service de
Rhumatologie. Centre Viggo Petersen. Hôpital Lariboisiere, Paris,
France, 4 CHU Pitié-Salpêtrière, Paris, France, 5 Hopital Purpan,
Toulouse CEDEX 9, France, 6 Hopital Lapeyronie, Montpellier,
France, 7 Paris-Descartes University, Cochin Hospital, Paris,
France, 8 Hopital R Salengro CHRU, Lille CEDEX, France, 9 Service
de médecine interne, Université Paris Est Créteil, AP-HP, Hôpital
Mondor Créteil, France, Creteil, France, 10 Cochin University
Hospital, Paris, France, 11 CHU de ROUEN, Rouen CEDEX, France,
12
Internal Medicine, Lille CEDEX, France, 13 Pellegrin Hospital,
Bordeaux, France, 14 Service de rhumatologie, Hôpitaux
Universitaires de Strasbourg, Strasbourg, France, Strasbourg,
France, 15 France, 16 Epidemiology, Paris, France, 17 Université Paris-
Sud, Le Kremlin Bicetre, France
2:45 pm
1642. Risk Factors for Major Adverse Cardiovascular Events in
Rheumatoid Arthritis Patients Treated with Tocilizumab
Vijay Rao 1 , Andrey Pavlov 2 , Micki Klearman 1 , David Musselman 3 ,
Jon T. Giles 4 , Joan M. Bathon 4 , Naveed Sattar 5 and Janet S.
Lee 3 , 1 Genentech, San Francisco, CA, 2 Everest, Toronto, 3 Roche,
Nutley, NJ, 4 Columbia University Medical Center, New York, NY,
5
University of Glasgow, Glasgow, United Kingdom
3:00 pm
1643. B Cell Repopulation and Rheumatoid Factor Predict
Duration of Response to Rituximab in Rheumatoid Arthritis
Edward M. Vital 1 , Sudipto Das 2 , Shouvik Dass 1 , Maya H. Buch 3 ,
Frederique Ponchel 1 , Andrew Rawstron 1 and Paul Emery 4 , 1 NIHR
Leeds Biomedical Research Unit, University of Leeds and Leeds
Teaching Hospitals NHS Trust, Leeds, United Kingdom, 2 NIHR
Leeds Musculoskeletal Biomedical Research Unit, University of
Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, United
Kingdom, 3 University of Leeds, Leeds, United Kingdom, 4 NIHR-
Leeds Biomedical Research Unit and Leeds Institute of Molecular
Medicine, University of Leeds, Leeds, United Kingdom
3:15 pm
1644. Is Screening for JC-Polyomavirus by PCR or Detection of
Antibodies Useful in Patients with Rheumatic Diseases Who
Are Treated with Rituximab
Jens Verheyen 1 , Eugen Feist 2 , Kseniya Maizus 1 , Zebulon Tolman 1 ,
Elena Knops 1 , Tim Waterboer 3 , Gerd R. Burmester 4 , Michael
Pawlita 3 , Herbert Pfister 1 and Andrea Rubbert 1 , 1 University of
Cologne, Cologne, Germany, 2 Charité Medical School, Berlin,
Germany, 3 German Cancer Research Center, Heidelberg,
Germany, 4 Charité University Medicine, Berlin, Germany
3:30 pm
1645. Efficacy of Different Doses of Rituximab for the
Treatment of RA: Data From the CERERRA Collaboration
Katerina Chatzidionysiou 1 , Elisabeth Lie 2 , Evgeny L. Nasonov 3 ,
Galina Lukina 3 , Merete L. Hetland 4 , Ulrik Tarp 5 , Ioan Ancuta 6 ,
Karel Pavelka 7 , Dan C. Nordström 8 , Cem Gabay 9 , Helena
Canhao 10 , Matija Tomsic 11 , Piet LC van Riel 12 , Juan J. Gomez-
Reino 13 , Tore K. Kvien2 and Ronald F. van Vollenhoven 1 ,
1
Karolinska Institute, Stockholm, Sweden, 2 Diakonhjemmet
Hospital, Oslo, Norway, 3 ARBITER, Institute of Rheumatology,
Moscow, Russia, 4 Copenhagen University Hospital at Glostrup,
on behalf of DANBIO, Copenhagen, Denmark, 5 Aarhus
University Hospital, Aarhus, Denmark, 6 Cantacuzino Hospital,
Bucharest, Romania, 7 1Institute of Rheumatology, Department
of Experimental Rheumatology, 1st Faculty of Medicine, Charles
University in Prague, Prague, Czech Republic, 8 ROB-FIN, Helsinki
University Central Hospital, Helsinki, Finland, 9 for the SCQM
registry, University Hospitals of Geneva, Geneva, Switzerland,
10
Lisbon Medical Academic Medical Center on behalf of
Rheumatic Diseases Portuguese Register, Lisbon, Portugal,
11
University Medical Centre Ljubjana, Ljubljana, Slovenia,
12
Radboud University Nijmegen Medical Centre, Nijmegen,
Netherlands, 13 Hospital Clinico Universitario, Santiago, Spain
3:45 pm
1646. Seropositivity and Response to RTX: Data From the
CERERRA Collaboration
Katerina Chatzidionysiou 1 , Elisabeth Lie 2 , Evgeny L. Nasonov 3 ,
Galina Lukina 3 , Merete L. Hetland 4 , Ulrik Tarp 5 , Ioan Ancuta 6 ,
Karel Pavelka 7 , Dan C. Nordström 8 , Cem Gabay 9 , Helena
Canhao 10 , Matija Tomsic 11 , Piet LCM Van Riel 12 , Juan J. Gomez-
Reino 13 , Tore K. Kvien 2 and Ronald F. van Vollenhoven 1 ,
1
Karolinska Institute, Stockholm, Sweden, 2 Diakonhjemmet
Hospital, Oslo, Norway, 3 ARBITER, Institute of Rheumatology,
Moscow, Russia, 4 DANBIO, Copenhagen University Hospital at
MONDAY
November 7, 2011
2011 Program Book 69