Program Book - Confex

ACR Poster Session A
487. Cathepsin S Activity Measurements in Tears As a Putative
Marker of Sjögren’s Syndrome. Jay Zhu 1 , Daniel G. Arkfeld 1 ,
W. Stohl 1 , Srikanth R. Janga 2 , J. Martin Heur 3 , John Irvine 3
and Sarah F. Hamm-Alvarez 2 , 1 USC Keck School of Medicine,
Los Angeles, CA, 2 University of Southern California School
of Pharmacy, Los Angeles, CA, 3 Doheny Eye Institute, Los
Angeles, CA
488. Serum IL-21 Is Increased and Associated with Higher
Disease Activity and Higher Serum Levels of Markers of
B-Cell Activation in Primary Sjögren’s Syndrome. Jacques-
Eric Gottenberg 1 , Ghada Alsaleh 1 , Corinne Miceli-Richard 2 ,
Raphaèle Seror 3 , Joelle Benessiano 4 , Valerie Devauchelle-
Pensec 5 , Philippe Dieude 6 , Jean Jacques Dubost 7 , Anne-
Laure Fauchais 8 , Vincent Goeb 9 , Eric Hachulla 10 , Pierre yves
Hatron 11 , C. Larroche 12 , Véronique Le Guern 13 , Jacques
Morel 14 , Aleth Perdriger 15 , Xavier Puechal 16 , Stephanie Rist 17 ,
Alain Saraux 18 , Damien Sène 19 , Jean Sibilia 20 , Karine Inamo 21 ,
Philippe Ravaud2 2 and Xavier Mariette 23 , 1 Strasbourg
University Hospital, Strasbourg, France, 2 Hopital Bicêtre,
Le Kremlin Bicêtre, France, 3 Bicetre university hospital, LE
Kremlin-Bicetre, France, 4 Rheumatology, Paris Unervisity
Hospital BICHAT, France, 5 Brest Occidentale university,
Brest, France, 6 APHP, Hopital Bichat, Paris, France, 7 CHU
Gabriel Montpied, Clermont-Ferrand, France, 8 Hospital,
Limoges, France, 9 Rheumatology, Rouen Unervisity Hospital,
France, France, 10 Internal Medicine, Lille CEDEX, France,
11
Service de médecine interne, Hôpital Claude Huriez,
Université Lille II, Lille, France, Paris, France, 12 Hospital
University Bobigny, France, 13 Cochin Hospital, Paris, France,
14
Hopital Lapeyronie, Montpellier, France, 15 Hôpital Sud,
Rennes, France, 16 Le Mans General Hospital, Le Mans,
France, 17 Hospital University Orléans, France, 18 CHU de la
Cavale Blanche, Brest Cedex, France, 19 Pitie-Salpetriere
Hospital, Paris, France, 20 Service de rhumatologie, Hôpitaux
Universitaires de Strasbourg, Strasbourg, France, Strasbourg,
France, 21 Nihon Univ Hikarigoaka Hosp, Nerima-ku Tokyo,
Japan, 22 Hopital Hotel Dieu, Paris Descartes University, Paris,
France, 23 Université Paris-Sud, Le Kremlin Bicetre, France
489. Gene Expression Profiling in a Cohort of 275 European
American Sjögren’s Syndrome Patients and Controls.
Jennifer A. Kelly 1 , Christopher J. Lessard 1 , Indra Adrianto 1 ,
John A. Ice 1 , He Li 1 , Stuart B. Glenn 1 , Kimberly Hefner 2 , Evan
Glenn Vista 3 , Donald U. Stone 4 , Raj Gopalakrishnan 5 , Glen
D. Houston 4 , David M. Lewis 4 , Michael Rohrer 5 , Pamela
Hughes 5 , John B. Harley 6 , Courtney G. Montgomery 1 , James
Chodosh 7 , James A. Lessard 8 , Juan-Manuel Anaya 9 , Barbara
M. Segal 10 , Nelson L. Rhodus 5 , Lida Radfar 4 , M. Bart Frank 1 ,
Robert H. Scofield 11 and Kathy L. Moser 1 , 1 Oklahoma Medical
Research Foundation, Oklahoma City, OK, 2 Hefner Eye Care
and Optical Center, Oklahoma City, OK, 3 University of Santo
Tomas, Taguig City, Philippines, 4 University of Oklahoma
Health Sciences Center, Oklahoma City, OK, 5 University
of Minnesota, Minneapolis, MN, 6 Cincinnati Children’s
Hospital Medical Center and the US Department of Veterans
Affairs Medical Center, Cincinnati, OH, 7 Harvard Clinical
and Translational Science Center, Boston, MA, 8 Valley Bone
& Joint Clinic, Grand Forks, ND, 9 Universidad del Rosario-
Corporacion para Investigaciones Biologicas, Bogota,
Colombia, 10 Univ of Minnesota, Minneapolis, MN, 11 Arthritis
and Clinical Immunology Research Program, Oklahoma
Medical Research Foundation, US Department of Veterans
Affairs Medical Center and Department of Medicine,
University of Oklahoma Health Sciences Center, Oklahoma
City, OK
490. Cellular microRNAs and Sjögren’s Syndrome: Candidate
Regulators of Autoimmune Response and Autoantigen
Expression. Efstathia K. Kapsogeorgou, Vasiliki C. Gourzi,
Nikolaos C. Kyriakidis, Menelaos N. Manoussakis,
Haralampos M. Moutsopoulos and Athanasios G. Tzioufas,
Pathophysiology Dept, School of Medicine, National
University of Athens, Greece, Athens, Greece
491. Autoantibodies in Primary Sjögren Syndrome Patients
Induce Internalization of Muscarinic Type 3 Receptors.
Meihong Jin 1 , Sung-Min Hwang 1 , Alexander J. Davies 1 ,
Yonghwan Shin 1 , Jun-Seok Bae 1 , Chongho Lee 1 , Byoong-Yong
Choi 2 , Eun Young Lee 2 , Yeong Wook Song 2 and Kyungpyo
Park 1 , 1 Seoul National University and Dental Research
Institute, Seoul, South Korea, 2 Seoul National University
Hospital, Seoul, South Korea
492. Analysis of M3R Reactive T Cell Epitopes in M3R Induced
Autoimmune Sialoadenitis. Naomi Matsuo, Hiroto Tsuboi,
Mana Iizuka, Yuya Kondo, Isao Matsumoto and Takayuki
Sumida, Division of Clinical Immunology, Doctoral Program
in Clinical Sciences, Graduate School of Comprehensive
Human Sciences, University of Tsukuba, Tsukuba, Ibaraki,
Japan
493. The Sjogren’s Syndrome-Related Autoantigen Ro52 Is a
Pro-Apoptotic Molecule Upon Oxidative Stress. Siti NA
Jauharoh 1 , Seiji Kawano 1 , Jun Saegusa 1 , Takeshi Sugimoto 1 ,
Daisuke Sugiyama 1 , Osamu Tokuno 1 , Chiyo Kurimoto 1 ,
Yumiko Nobuhara 2 , Yuji Nakamachi 1 , Bambang Ardianto 3
and Shunichi Kumagai 1 , 1 Kobe University Graduate School
of Medicine, Kobe, Japan, 2 Saiseikai Nakatsu Hospital,
Osaka, Japan, 3 Gadjah Mada University Faculty of Medicine
Department of Child Health, Yogyakarta, Indonesia
494. VIP / VPAC System Involved in the Interaction of Primary
Sjögren Syndrome Immune Cells and a Human Salivary
Gland Epithelial Cell Line. Vanesa C. Hauk 1 , Laura
Fraccaroli 1 , Esteban Grasso 1 , Rosanna Ramhorst 1 , Alicia
Eimon 2 , Osvaldo Hubscher 2 and Claudia Perez Leiros 1 ,
1
School of Exact and Natural Sciences-CONICET, Buenos
Aires, Argentina, 2 CEMIC, Buenos Aires, Argentina
495. Regulatory T Cell Subset Defect in a Mouse Model
of Sjögren Syndrome. Scott M. Lieberman 1 , Portia A.
Kreiger 2 and Gary A. Koretzky 3 , 1 The Children’s Hospital
of Philadelphia, Philadelphia, PA, 2 Nemours/A.I. DuPont
Hospital for Children, Wilmington, DE, 3 University of
Pennsylvania, Philadelphia, PA
2011 Program Book 173